Vitamin D status and health‐related quality of life in patients with Type 2 diabetes

Krul-Poel, Yvonne H M; Westra, Sanne; Wijland, H. J. J. van; Stam, Frank; Lips, Paul; Pouwer, Frans; Şimşek, Suat

doi:10.1111/dme.12834

Cited by 9 publications

(6 citation statements)

References 30 publications

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“…There was no benefit of vitamin D in improving perceived physical health in the current study. One recent cross-sectional study of persons with T2DM ( n = 241) reported no association between vitamin D levels (grouped as <50 nmol/l and >50 nmol/l) and their perceived physical or mental health (using the SF-36) [ 58 ]. Similarly, a systematic review reported no overall association between vitamin D supplementation and health-related quality of life (using the SF-36).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes

Penckofer

Byrn

Adams

et al. 2017

Journal of Diabetes Research

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Objective The aim of this study was to determine the effect of vitamin D supplementation on improving mood (depression and anxiety) and health status (mental and physical) in women with type 2 diabetes mellitus (T2DM). Methods Fifty women with T2DM and significant depressive symptomology were enrolled into the “Sunshine Study,” where weekly vitamin D supplementation (ergocalciferol, 50,000 IU) was given to all participants for six months. The main outcomes included (1) depression (Center for Epidemiologic Studies Depression, CES-D, and Patient Health Questionnaire, PHQ-9), (2) anxiety (State-Trait Anxiety), and (3) health status (Short Form, SF-12). Results Forty-six women (92%) completed all visits. There was a significant decrease in depression (CES-D and PHQ-9, p < 0.001) and anxiety (state and trait, p < 0.001). An improvement in mental health status (SF-12, p < 0.001) was also found. After controlling for covariates (race, season of enrollment, baseline vitamin D, baseline depression (PHQ-9), and body mass index), the decline in depression remained significant (CES-D, p < 0.001). There was a trend for a better response to supplementation for women who were not taking medications for mood (antidepressants or anxiolytics) (p = 0.07). Conclusions Randomized trials to confirm that vitamin D supplementation can improve mood and health status in T2DM women are needed.

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Section: Discussionmentioning

confidence: 99%

Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes

Penckofer

Byrn

Adams

et al. 2017

Journal of Diabetes Research

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“…However, greater than 90% of this number is either overweight or obese [3]. Diabetes mellitus has a high impact on morbidity and mortality as diabetes mellitus associated with 2-4 fold risk for cardiovascular diseases and stroke in addition, diabetes is considered as a leading cause of renal disorders [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Relationship between Status of Vitamin D and Adhesive Molecules Biomarkers in Saudi Patients with Type 2 Diabetes Mellitus

Al-Sharif¹

2017

EMIJ

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Background: Vitamin D (25-OHD) has an essential protective action on vascular endothelium and endothelial dysfunction is a risk valuable marker for risk of cardiovascular disorders, which are common among patients with Type 2 diabetes mellitus (T2DM).Objective: the aim of this study was to detect the link between level of vitamin D and adhesive molecules biomarkers in Saudi patients with type 2 diabetes mellitus. Material and Methods:Two hundred Saudi patients with T2DM of both sexes (132 females and 68 males), their age range was 48-59 years, the diabetes chronicity range was 9-11years and their body mass index (BMI) range was 31 to 37 Kg/m 2 . All participants received oral hypoglycemic agents e.g. metformin and/or pioglitazone and were selected from the Internal Medicine Out-patient Clinic, King Abdulaziz Teaching Hospital, Jeddah, Saudi Arabia. Participants with respiratory failure, hepatitis, renal failure, heart failure, pregnancy and smokers excluded from the study. According to vitamin D level, participants were assigned to one of three groups: vitamin D deficiency group (A): 25-OHD <20 ng/ml, vitamin D insufficiency group (B): 25-OHD =20-30 ng/ml and normal vitamin D group(C) 25-OHD >30 ng/ml. Results:The mean values of VCAM-1, ICAM-1 and E-selectin were significantly higher in vitamin D deficiency group (A) compared to vitamin D insufficiency group (B) and normal vitamin D group(C). Moreover, vitamin D showed a strong inverse relationship with VCAM-1, ICAM-1 and E-selectin in the three groups (P<0.05). Conclusion:There is an association between vitamin D deficiency and abnormal levels of adhesive molecules biomarkers in Saudi patients with type 2 diabetes mellitus.

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“…The recent studies indicate that vitamin D deficiency may increase diabetes risk (13). Scientific studies draw our attention to effects of vitamin D on diabetes and glucose control (14,15). According to recent studies, vitamin D deficiency affects glucose metabolism and actually causes diabetes rather than obesity (16,17).…”

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin D3 and Resveratrol on Memory and Learning Impairment in Mice With Streptozotocin Induced Diabetes

Kukula¹

2019

Acta Poloniae Pharmaceutica - Drug Research

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This study was conducted for investigating the effects of chronically administered vitamin D 3 and resveratrol, which has antioxidant properties, on memory and learning impairment caused by streptozotocininduced diabetes. Saline was administered to the mice in the first group. Streptozotocin (60 mg/kg, i.p.) was given to the mice in the second group for 3 consecutive days and no treatment was performed. Vitamin D 3 (800 IU/kg, i.p.) was given to the streptozotocin-induced hyperglycemic mice in the third group for 4 weeks. Resveratrol (40 mg/kg, i.p.) was given to the streptozotocin-induced hyperglycemic mice in the fourth group for 4 weeks. Then, the passive avoidance test was applied to the mice. A significant difference was found between DM+Vit D 3 group (21.6 ± 1.7, n = 7) and diabetic control group (28 ± 2.6, n = 7) in the acquisition test (p < 0.001). A similar result was observed between diabetic-resveratrol group (23.7 ± 2.5, n = 7) and the untreated diabetic mice group (28 ± 2.6, n = 7). There was a significant difference. 4-week vitamin D 3 (400 IU/day, i.p.) and 4-week resveratrol (40 mg/kg, i.p.) treatments given to streptozotocin-induced diabetic mice were observed to significantly improved the passive avoidance acquisition and retention times. These results show the positive effects of vitamin D 3 on memory.

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Vitamin D status and health‐related quality of life in patients with Type 2 diabetes

Cited by 9 publications

References 30 publications

Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes

Vitamin D Supplementation Improves Mood in Women with Type 2 Diabetes

Relationship between Status of Vitamin D and Adhesive Molecules Biomarkers in Saudi Patients with Type 2 Diabetes Mellitus

Effects of Vitamin D3 and Resveratrol on Memory and Learning Impairment in Mice With Streptozotocin Induced Diabetes

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