Vitamin D status and COVID-19 in older adults

Mandal, Amit K J; Baktash, Vadir; Hosack, Tom; Missouris, Constantinos G

doi:10.1007/s40520-020-01716-8

Cited by 23 publications

(15 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…116 Specifically, Black, Asian, and Minority ethnic community may be more susceptible to severe presentations of COVID-19. 117 For example, in Chicago, more than 50% of COVID-19 cases and nearly 70% of COVID-19 deaths involve Black individuals, although Blacks make up only 30% of the population. Similarly, in Louisiana, 70.5% of deaths have occurred among Black persons, who represent 32.2% of the state's population.…”

Section: Vitamin D and Ace2mentioning

confidence: 99%

“…There are now strong indications that the acquisition, transmission, and severity of COVID‐19 might be influenced by ethnicity 116 . Specifically, Black, Asian, and Minority ethnic community may be more susceptible to severe presentations of COVID‐19 117 . For example, in Chicago, more than 50% of COVID‐19 cases and nearly 70% of COVID‐19 deaths involve Black individuals, although Blacks make up only 30% of the population.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity

Getachew

Tizabi

2021

Journal of Medical Virology

View full text Add to dashboard Cite

Coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) virus, disproportionally targets older people, particularly men, ethnic minorities, and individuals with underlying diseases such as compromised immune system, cardiovascular disease, and diabetes. The discrepancy in COVID‐19 incidence and severity is multifaceted and likely involves biological, social, as well as nutritional status. Vitamin D deficiency, notably common in Black and Brown people and elderly, is associated with an increased susceptibility to many of the diseases comorbid with COVID‐19. Vitamin D deficiency can cause over‐activation of the pulmonary renin‐angiotensin system (RAS) leading to the respiratory syndrome. RAS is regulated in part at least by angiotensin‐converting enzyme 2 (ACE2), which also acts as a primary receptor for SARS‐CoV‐2 entry into the cells. Hence, vitamin D deficiency can exacerbate COVID‐19, via its effects on ACE2. In this review we focus on influence of age, gender, and ethnicity on vitamin D‐ACE2 interaction and susceptibility to COVID‐19.

show abstract

Section: Vitamin D and Ace2mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity

Getachew

Tizabi

2021

Journal of Medical Virology

View full text Add to dashboard Cite

show abstract

“…Lockdowns, implemented to minimize the spread of COVID-19, are therefore detrimental to vitamin D synthesis as people are prevented from going out from their homes and absorbing the sunshine, which has a cumulative effect in the winter months when COVID-19 is more prevalent. The Black and Asian populations produce less vitamin D as a result of a higher skin melanin content than those with white skin [ 71 ]. Excess exposure to sunlight is the major cause of skin cancer [ 72 ].…”

Section: Vitamin Dmentioning

confidence: 99%

Essential sufficiency of zinc, ω-3 polyunsaturated fatty acids, vitamin D and magnesium for prevention and treatment of COVID-19, diabetes, cardiovascular diseases, lung diseases and cancer

Story¹

2021

Biochimie

View full text Add to dashboard Cite

Despite the development of a number of vaccines for COVID-19, there remains a need for prevention and treatment of the virus SARS-CoV-2 and the ensuing disease COVID-19. This report discusses the key elements of SARS-CoV-2 and COVID-19 that can be readily treated: viral entry, the immune system and inflammation, and the cytokine storm. It is shown that the essential nutrients zinc, ω-3 polyunsaturated fatty acids (PUFAs), vitamin D and magnesium provide the ideal combination for prevention and treatment of COVID-19: prevention of SARS-CoV-2 entry to host cells, prevention of proliferation of SARS-CoV-2, inhibition of excessive inflammation, improved control of the regulation of the immune system, inhibition of the cytokine storm, and reduction in the effects of acute respiratory distress syndrome (ARDS) and associated non-communicable diseases. It is emphasized that the non-communicable diseases associated with COVID-19 are inherently more prevalent in the elderly than the young, and that the maintenance of sufficiency of zinc, ω-3 PUFAs, vitamin D and magnesium is essential for the elderly to prevent the occurrence of non-communicable diseases such as diabetes, cardiovascular diseases, lung diseases and cancer. Annual checking of levels of these essential nutrients is recommended for those over 65 years of age, together with appropriate adjustments in their intake, with these services and supplies being at government cost. The cost:benefit ratio would be huge as the cost of the nutrients and the testing of their levels would be very small compared with the cost savings of specialists and hospitalization.

show abstract

“…Despite this, vitamin D can induce ACE-2 expression. However, while the increase in ACE-2 expression was initially predicted to amplify the risk of infection and severity, ACE-2 has also been shown to protect against acute lung injury [33].…”

Section: Vitamin D and Immune Function In The Elderlymentioning

confidence: 99%

Major Approaches to the Dosage of Vitamin D in the Elderly: A Systematic Review

Cadamuro¹,

Filho²

2021

MedNEXT

View full text Add to dashboard Cite

Introduction: In the scenario of vitamin D deficiency, this incident is prevalent and with risks to public health in the world, reaching approximately 90% of individuals. Hypovitaminosis D can cause, mainly in the elderly, lower bone mineral density, fractures, muscle weakness, falls, and acute respiratory infection. Objective: To evaluate the main clinical results on vitamin D levels in the elderly, as well as to analyze which daily or weekly dose of vitamin D is most effective in the elderly in reducing the number of falls and fractures. Methods: The present study developed a systematic review, addressing randomized clinical studies, diverse clinical studies, systematic reviews, meta-analysis, and the latest international consensus, following the rules of PRISMA. Results and Conclusion: A total of 152 articles were found involving the dosage and the impact of vitamin D in the elderly. In total, 72 articles were evaluated in full and 30 were included. According to the main literary findings, vitamin D deficiency implies problems with mineralization and bone mineral density, causing fractures and an increase in the number of elderly falls. In this sense, SBEM recommends maintaining vitamin D concentrations above 30 ng/mL. Also, vitamin D deficiency points to the occurrence of neurological diseases such as cognitive decline, risk of Alzheimer's disease, and depression. In the current scenario of the pandemic, vitamin D points as an important modulator of the immune system, and its deficiency promotes the unregulated release of cytokines, leading to complications in patients with COVID-19.

show abstract

Vitamin D status and COVID-19 in older adults

Cited by 23 publications

References 5 publications

Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity

Vitamin D and COVID‐19: Role of ACE2, age, gender, and ethnicity

Essential sufficiency of zinc, ω-3 polyunsaturated fatty acids, vitamin D and magnesium for prevention and treatment of COVID-19, diabetes, cardiovascular diseases, lung diseases and cancer

Major Approaches to the Dosage of Vitamin D in the Elderly: A Systematic Review

Contact Info

Product

Resources

About