Vitamin D Receptor Gene Polymorphism and Vitamin D Plasma Concentration: Correlation with Susceptibility to Tuberculosis

Rashedi, Jalil; Asgharzadeh, Mohammad; Moaddab, Seyyed Reza; Sahebi, Leyla; Khalili, Majid; Mazani, Mohammad; Abdolalizadeh, Jalal

doi:10.5681/apb.2014.089

Cited by 12 publications

(7 citation statements)

References 14 publications

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“…A survey conducted by Hossein-Nezhad et al (2014) determined that vitamin D deficiency correlated with the VDR Fok I polymorphism in 760 Iranian patients who had undergone angiography due to suspected coronary artery disease (CAD), as vitamin D deficiency that is more prevalent in CAD patients might be result from Fok I polymorphism [ 90 ]. At the same time, Rashedi et al (2014)’s study observed that increases in 25(OH)D serum levels in individuals with VDR Fok I’s ff genotype and low 25(OH)D serum levels might protect them against active tuberculosis [ 91 ].…”

Section: Discussionmentioning

confidence: 99%

Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

et al. 2023

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(1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. However, several complications were reported, such as vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS, and whether the vitamin D receptor (VDR) gene’s TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI’s allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f.

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Section: Discussionmentioning

confidence: 99%

Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

et al. 2023

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“…FokI VDR SNP was found to be associated with essential hypertension, metabolic syndrome, acromegaly, leprosy, hepatocellular carcinoma, multiple sclerosis, urolithiasis and skeletal muscle strength in COPD patients 13,22,23,29,35,44,47,54 . From the perspective of respiratory ailments, FokI VDR SNP was found to be associated with asthma and tuberculosis 39,41,42 . However, in our study, neither the genotype nor the allele of FokI VDR single nucleotide polymorphism was associated with COPD.…”

Section: Discussionmentioning

confidence: 99%

“…These SNP s have been found to be associated with the efficacy of antiresorptive treatments in postmenopausal women (with BsmI) 34 , essential hypertension (with FokI) 35 , metabolic syndrome (with FokI) 23 , prostate cancer (with ApaI) 36 , Leprosy (with FokI and ApaI) 13 , lumbar spine pathogenesis (with BsmI, ApaI and TaqI) 37 and multiple familial sclerosis (with TaqI) 38 . Moreover, in the perspective of respiratory ailments, both FokI and ApaI VDR SNPs were found to be associated with asthma 11,39,40 and FokI VDR SNP was found to be associated with tuberculosis 41,42 . In addition, ApaI was associated with osteoporosis 43 and FokI along with BsmI were associated with skeletal muscle strength in COPD patients 44 .…”

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confidence: 98%

Association of Vitamin-D Receptor Gene Single Nucleotide Polymorphism (FokI) with COPD

Akter,

Riad,

Ali

et al. 2023

CeMeC Journal

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Background: Vitamin D receptor gene (VDR) polymorphism and its association with various diseases have been previously investigated. But the association of vitamin D receptor gene polymorphism with COPD has not been investigated yet. Objective: To assess the association between vitamin D receptor gene polymorphism (FokI) and COPD. Methods: This cross sectional study was carried out in the Department of Physiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from March 2019 to February 2020. For this study, 15 (fifteen) pulmonologists diagnosed COPD patients with age 40 to 80 years (post-bronchodilator FEV1/FVC<0.70 and FEV1<80% predicted) and 15 (fifteen) apparently healthy age-matched individuals (for comparison), were selected. The single nucleotide polymorphism of vitamin D receptor gene (FokI) of all subjects was assessed by PCR-RFLPs. Data were expressed as mean ± SD and percentage. Statistical analysis was done by independent sample ‘t’ test and chi-square test. In the interpretation of the results, ≤0.05 level of probability (p) was accepted as significant. Results: The frequency distribution of FokI genotype was 13.33% (FF), 73.34% (Ff), 13.33% (ff) and 13.33% (FF), 80% (Ff), 6.66% (ff) COPD patients and healthy subjects, respectively. Associations of FokI [FF (OR 1,95% CI 0.12-8.21, p=1.00); Ff (OR 0.68,95% CI 0.12-3.78, p=0.66); ff (OR 2.15,95% CI 0.17-26.67, p=0.54)] VDRSNP with COPD was statistically non-significant. Conclusion: The present study reveals that the FokI of VDR SNP is not associated with COPD. Central Medical College Journal Vol 6 No 1 January 2022 Page: 14-21

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“…However, subsequent studies showed conflicting or different results. A number of studies in sub-Saharan Africa, Birmingham, US, Mwanza, Tanzania, Tanzania, Malawi, and London populations have drawn different significant associated conclusions (29)(30)(31)(32)(33)(34)(35)(36)(37). However, the Indonesia and Hong Kong studies (20,35) failed to find a significant association between vitamin D levels and TB.…”

Section: Discussionmentioning

confidence: 99%

The Potential Role of Vitamin D in the Development of Tuberculosis in Chinese Han Population: One Case-Control Study

Cai

Hou²,

Liu³

et al. 2022

Front. Med.

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Background and aims:Spinal serum 25-hydroxyvitamin D [25[OH]D] status plays an important role in mediating innate immune responses by acting as a cofactor for induction of antimycobacterial activity and is thus involved in the development of Tuberculosis (TB). Results reported regarding the association of vitamin D with TB remained controversial. We aimed to identify any common association between 25[OH]D status and TB in the Chinese Han population.Methods280 subjects (70 TB patients and 210 matched controls) were recruited. TB cases were diagnosed based on the presence of acid-fast bacilli on smears from sputum and MTB isolation. Healthy controls were randomly selected from four local community-based populations. 25[OH]D was detected by electrochemiluminescence immunoassay (ECLIA) on Roche Elecsys before the initial treatment. Multivariable logistic regression analysis was used to examine the association of Vitamin D with TB.ResultsThere was no significant difference in the serum vitamin D level between total cases and controls, but we found a strong tendency toward a higher serum vitamin D level in male population (P < 0.05) with TB but not in females. High serum vitamin D increased the risk of TB in the Chinese Han population (OR = 1.035, 95%CI: 1.001–1.070, P < 0.05). The serum vitamin D level was significantly decreased with age increasing in cases and controls (all P < 0.001).ConclusionsHigh serum vitamin D may be an independent risk factor for TB in the Chinese Han population.

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Vitamin D Receptor Gene Polymorphism and Vitamin D Plasma Concentration: Correlation with Susceptibility to Tuberculosis

Cited by 12 publications

References 14 publications

Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

Association of Vitamin-D Receptor Gene Single Nucleotide Polymorphism (FokI) with COPD

The Potential Role of Vitamin D in the Development of Tuberculosis in Chinese Han Population: One Case-Control Study

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