Bariatric Surgery and Vitamin D: Trends in Older Women and Association with Clinical Features and VDR Gene Polymorphisms

Abstract

(1) Background: Obesity and its comorbidities can cause burdens and limitations. Bariatric surgery (BS) is indicated as a safe procedure to reduce body mass and improve present comorbidities. However, several complications were reported, such as vitamin D [25(OH)D] deficiency. We evaluated if 25(OH)D serum levels relate to clinical characteristics, symptoms, or habits in women after their BS, and whether the vitamin D receptor (VDR) gene’s TaqI and FokI polymorphisms affected 25(OH)D levels and the total body bone mineral density (TBBMD). (2) Methods: This cohort cross-sectional comparative analytical prospective study consisted of 27 women, 61.6 ± 5.0 years, submitted to BS one year prior at a public reference hospital, DF-Brazil. All participants were asked to follow the physical and dietary activity recommendations and received vitamin D3 supplements. Their anthropometric, biochemical, and immunological measurements and blood samples were obtained. (3) Results: 73.3% of participants had low 25(OH)D levels, and their levels correlated positively with TBBMD and negatively with systolic pressure. VDR TaqI did not affect 25(OH)D levels, whereas VDR FokI’s allele f presence correlated to a median rise in 25(OH)D levels. Neither polymorphism correlated to TBBMD. (4) Conclusions: 25(OH)D levels were positively correlated with TBBMD, negatively with systolic blood pressure, and were higher in those with the VDR FokI allele f.

Morar No Campo Ou Na Cidade: O Que Muda Na Composição Corporal E Na Força?

“…Os resultados encontrados revelaram que tanto os moradores de meio rural quanto urbano apresentam médias corporais indicativas de sobrepeso (69,96kgs com IMC de 27,59 no meio urbano e 75,67kgs com IMC 29,35 no meio rural). Esses achados sugerem a existência de um problema nutricional em ambas as populações, com o foco para a região rural que apresentou alguns participantes em situação de obesidade (Benito et al, 2023).…”

Genetic association of the BsmI variant of vitamin D receptor gene with risk of morbid obesity

“…Data show a widespread expression of VitD-related metabolic enzymes and VDR in human adipose tissue 14 . Since VDRs are present in various body tissues, their gene polymorphisms may influence the risk of VitD-related metabolic disorders and regulate the receptor's effectiveness based on VitD status 15 .…”