Vitamin D levels in relation to low back pain during adolescence

Al-Taiar, Abdullah; Rahman, Abdur; Al-Sabah, Reem; Shaban, Lemia; AlBaloul, Anwar H; Banaee, Sean; Akpinar‐Elci, Muge

doi:10.1017/s0007114520000720

Cited by 9 publications

(8 citation statements)

References 52 publications

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“…The study was conducted within a project that aimed to assess vitamin D status in middle schoolchildren (11–16 years) in Kuwait. The details of the project have been described previously [ 37 , 38 ]. In this project, a nationally representative sample of middle schoolchildren was selected using probability proportional to size sampling method.…”

Section: Methodsmentioning

confidence: 99%

Vitamin D level in relation to depression symptoms during adolescence

Al-Sabah

Al-Taiar

Shaban

et al. 2022

Child Adolesc Psychiatry Ment Health

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Background This study aimed to investigate the association between 25-hydroxyvitamin D (25(OH)D) and depression symptoms among adolescents in Kuwait, a country with a high prevalence of vitamin D deficiency. Methods A school based cross-sectional study was conducted on randomly selected 704 adolescents in middle schools. Data on depression symptoms were collected using the Children’s Depression Inventory (CDI). Data on covariates were collected from the parents by self-administered questionnaire and from adolescents by face-to-face interview. Blood samples were analyzed in an accredited laboratory; and 25(OH)D was measured using liquid chromatography-tandem mass spectrometry. Results Of 704 adolescents, 94 (13.35%; 95%CI:10.35–17.06%) had depression symptom (a score of 19 or more on the CDI). There was no significant difference in the median CDI score between different vitamin D status (p = 0.366). There was also no significant correlation between serum 25(OH)D concentration and CDI score (Spearman’s rank correlation = 0.01; p = 0.825).There was no significant association between 25(OH)D and depression symptoms whether 25(OH)D was fitted as a continuous variable (crude odds ratio (OR) 0 .99 [95%CI: 0.98, 1.01], p = 0.458 and adjusted OR 1.01 [95%CI: 0.99, 1.02], p = 0.233), categorical variable as per acceptable cut-of points (crude analysis p = 0.376 and adjusted analysis p = 0.736), or categorical variable as quartiles (crude analysis p = 0.760 and adjusted analysis p = 0.549). Conclusion Vitamin D status does not seem to be associated with depression symptoms among adolescents in our setting. Nevertheless, it is important to have sufficient vitamin D levels during adolescence for several other health benefits.

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Section: Methodsmentioning

confidence: 99%

Vitamin D level in relation to depression symptoms during adolescence

Al-Sabah

Al-Taiar

Shaban

et al. 2022

Child Adolesc Psychiatry Ment Health

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“…The study group comprised a nationally representative sample of schoolgirls at public middle schools in all six governorates (provinces) in Kuwait that were selected randomly by probability proportional to size sampling method. This was conducted in the context of a project that aimed to estimate the prevalence of vitamin D deficiency among middle school children (details of the project, including the sampling methods, have been published previously [Al‐Taiar et al, 2018; Al‐Taiar et al, 2020]). Briefly, in 2016 (February–March), a team of trained data collectors drew blood samples and collected data on sociodemographic factors from the parents of selected students through a self‐administered questionnaire, while the data on factors related to lifestyle such as physical activity and smoking were collected by face‐to‐face interviews with the students using a structured questionnaire ( N = 722 schoolgirls).…”

Section: Methodsmentioning

confidence: 99%

“…All other biological markers were measured in an accredited clinical biochemistry laboratory in a teaching hospital, under strict quality control. The details of these measurements have been published previously including complete blood count (CBC), iron, ferritin, transferrin, transferrin saturation, vitamin B 12 , and intact parathyroid hormone (PTH) (Al‐Taiar et al, 2018; Al‐Taiar et al, 2020).…”

Section: Methodsmentioning

confidence: 99%

“…Then, they were centrifuged, and the serum was transferred to Eppendorf tubes and stored at À80 C for analysis. Details of measurement of Serum 25OHD have been published before (Al-Taiar et al, 2018;Al-Taiar et al, 2020). In brief, liquid chromatography-tandem mass spectrometry (LC-MS/ MS), which is the gold standard method of vitamin D F I G U R E 1 Study profile assessment (de la Hunty et al, 2010;Yetley et al, 2010), was used to measure 25OHD.…”

Section: Independent Variablementioning

confidence: 99%

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Is age of menarche directly related to vitamin D levels?

Al-Taiar

Al-Sabah

Shaban

et al. 2022

American J Hum Biol

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Introduction Very few studies have examined the direct link between age of menarche and vitamin D level and controversial results have been reported. This study aimed to investigate the association between vitamin D and age of menarche in a group of adolescent girls in an area with plenty of sunshine. Methods At baseline, data were collected on 722 middle schoolgirls that were randomly selected by probability proportional to size sampling method. Of this group, 598 were followed including 173 who had their menarche during the follow‐up. Serum 25‐hydroxyvitamin D (25OHD) was measured at baseline using liquid chromatography‐tandem mass spectrometry (LC‐MS/MS). Data on potential confounders were collected at baseline from the parents using self‐administered questionnaire and from schoolgirls through face‐to‐face interview. Multiple linear regression and time‐to‐event analysis were used to investigate the association between 25OHD concentration and age of menarche. Results The mean (SD) age of the study group was 12.51 (0.91) years while the main (SD) age of menarche was 11.82 (1.04) years. The prevalence of vitamin D deficiency (<50 nmol/L) among schoolgirls was 91.69%. We found no evidence for the association between 25OHD levels and age of menarche before (β, .00, 95% confidence interval (CI) [−0.01, 0.01]; p = .808) or after (β, .00, 95% CI [−0.01, 0.01]; p = .765) adjusting for potential confounders. We also found no evidence for association between 25OHD status and age of menarche before (p = .424) or after (p = .356) adjusting for potential confounders. Time‐to‐event analysis showed no association between 25OHD level or status and age of menarche (p = .850). Conclusion In Middle Eastern setting, where vitamin D deficiency is common despite plenty of sunshine, vitamin D is not a major determinant of the age at menarche. Regardless of the link between vitamin D and age of menarche, there are several other health benefits of having adequate vitamin D level during childhood and adolescence.

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“…Vitamin D receptors were found in various tissues and organs. Vitamin D can directly or indirectly regulate more than 200 genes, and its effects include promoting cell differentiation, inhibiting cell apoptosis, and inhibiting angiogenesis and anti-inflammatory [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

et al. 2021

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Background To observe the effects of vitamin D on the apoptotic human nucleus pulposus cells under tumor necrosis factor-α (TNF-α) treatment. Methods The gene expression data was downloaded from the NCBI Gene Expression Omnibus (GEO) database (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE34095). Differentially expressed genes between degenerative disc and non-degenerative disc were performed by R software. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) pathway enrichment analyses were performed using The Database for Annotation, Visualization and Integrated Discovery (DAVID). Then, the human nucleus pulposus tissue was harvested from 12 patients according to the modified Pfirrmann classification and human nucleus pulposus cells were obtained from digestion of herniated nucleus pulposus tissue. The collected nucleus pulposus cells were treated with different concentration of TNF-α, and cellular apoptosis was measured by flow cytometry. Then, human nucleus pulposus cells were divided into following groups: normal culture medium, TNF-α treated, TNF-α, and vitamin D-treated groups. Cellular apoptosis rate was quantified by flow cytometry. Protein expression of p-p65, p65, and IkBa was detected with western blot analysis. Results A total of 536 differentially expressed genes were identified through bioinformatic analysis. KEGG pathway revealed that NF-kB signaling pathway was involved in the process of disc degeneration. In the NP cell cultures, vitamin D significantly increased cell proliferation potency. Furthermore, vitamin D inhibited TNF-α induced apoptosis of human nucleus pulposus cells. Vitamin D reduced the phospho-NF-κB/p65 expression in the TNF-α-treated NP cells. Conclusion Vitamin D can attenuate TNF-α-induced NP cells apoptosis through interfering with the NF-κB pathway.

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Vitamin D levels in relation to low back pain during adolescence

Cited by 9 publications

References 52 publications

Vitamin D level in relation to depression symptoms during adolescence

Vitamin D level in relation to depression symptoms during adolescence

Is age of menarche directly related to vitamin D levels?

Vitamin D inhibits TNF-α induced apoptosis of human nucleus pulposus cells through regulation of NF-kB signaling pathway

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