In China in 2010, a disease outbreak in egg-laying ducks was associated with a flavivirus. The virus was isolated and partially sequenced. The isolate exhibited 87%–91% identity with strains of Tembusu virus, a mosquito-borne flavivirus of the Ntaya virus group. These findings demonstrate emergence of Tembusu virus in ducks.
Histone (de)acetylation is a highly conserved chromatin modification that is vital for development and growth. In this study, we identified a role in seed dormancy for two members of the histone deacetylation complex in Arabidopsis thaliana, SIN3-LIKE1 (SNL1) and SNL2. The double mutant snl1 snl2 shows reduced dormancy and hypersensitivity to the histone deacetylase inhibitors trichostatin A and diallyl disulfide compared with the wild type. SNL1 interacts with HISTONE DEACETYLASE19 in vitro and in planta, and loss-of-function mutants of SNL1 and SNL2 show increased acetylation levels of histone 3 lysine 9/18 (H3K9/18) and H3K14. Moreover, SNL1 and SNL2 regulate key genes involved in the ethylene and abscisic acid (ABA) pathways by decreasing their histone acetylation levels. Taken together, we showed that SNL1 and SNL2 regulate seed dormancy by mediating the ABA-ethylene antagonism in Arabidopsis. SNL1 and SNL2 could represent a crosslink point of the ABA and ethylene pathways in the regulation of seed dormancy.
The DArk Matter Particle Explorer (DAMPE), a high energy cosmic ray and γ-ray detector in space, has recently reported the new measurement of the total electron plus positron flux between 25 GeV and 4.6 TeV. A spectral softening at ∼ 0.9 TeV and a tentative peak at ∼ 1.4 TeV have been reported. We study the physical implications of the DAMPE data in this work. The presence of the spectral break significantly tightens the constraints on the model parameters to explain the electron/positron excesses. The spectral softening can either be explained by the maximum acceleration limits of electrons by astrophysical sources, or a breakdown of the common assumption of continuous distribution of electron sources at TeV energies in space and time. The tentive peak at ∼ 1.4 TeV implies local sources of electrons/positrons with quasi-monochromatic injection spectrum. We find that the cold, ultra-relativistic e + e − winds from pulsars may give rise to such a structure. The pulsar is requird to be middle-aged, relatively slowly-rotated, mildly magnetized, and isolated in a density cavity. The annihilation of DM particles (m χ ∼ 1.5 TeV) into e + e − pairs in a nearby clump or an over-density region may also explain the data. In the DM scenario, the inferred clump mass (or density enhancement) is about 10 7 − 10 8 M ⊙ (or 17 − 35 times of the canonical local density) assuming a thermal production cross section, which is relatively extreme compared with the expectation from numerical simulations. A moderate enhancement of the annihilation cross section via, e.g., the Sommerfeld mechanism or non-thermal production, is thus needed.
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