Vitamin D level in relation to depression symptoms during adolescence

Al-Sabah, Reem; Al-Taiar, Abdullah; Shaban, Lemia; Albatineh, Ahmed N.; Alddin, Reem Sharaf; Durgampudi, Praveen

doi:10.1186/s13034-022-00489-4

Cited by 11 publications

(10 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Unexpectedly, we did not find a cross-sectional correlation between vitamin and depression symptoms at wave 1 and wave 3. Consistently, a study also found a lack of cross-sectional association between vitamin D and depressive symptoms in early adolescents (Al-Sabah et al, 2022). Additionally, no significant association between conditional changes in serum vitamin D levels and depression risk was observed.…”

Section: Discussionmentioning

confidence: 70%

Vitamin D and depressive symptoms in an early adolescent cohort

Wang

Yuan²,

Chang³

et al. 2022

Psychol. Med.

View full text Add to dashboard Cite

Background To explore the cross-sectional and longitudinal association between vitamin D and depressive symptoms across early adolescence. Methods This longitudinal study included 1607 early adolescents [mean (s.d.) age, 12.49 years; 972 (60.5%) males] from the Chinese Early Adolescents Cohort, recruited from a middle school in Anhui Province and followed up annually (2019–2021). Serum 25(OH)D levels were measured in both 2019 and 2021. Self-reports on depression were assessed at each of three time points from 2019 to 2021. Results In the whole sample, higher baseline serum 25(OH)D levels were linked with a lower risk of cumulative incident depression within two-year follow-ups (adjusted RR = 0.97, 95% CI 0.94–0.99) and the increasing trajectory of depression symptoms across the three waves (adjusted RR = 0.97, 95% CI 0.95–0.99). Baseline vitamin D deficiency (VDD) (adjusted RR = 1.50, 95% CI 1.10–2.05) were associated with an increased risk for the increasing trajectory of depression symptoms across the three waves. Remitted VDD was positively related to one dichotomous depression symptoms across three waves (adjusted OR 2.15, 95% CI 1.15–4.01). The above-mentioned significant association was also found in males. Additionally, baseline VDD (adjusted OR 1.59, 95% CI 1.04–2.44) and persistent VDD (adjusted OR 1.58, 95% CI 1.02–2.60) were linked to an increased risk of having two dichotomous depression symptoms only in males. Conclusions Our results highlight a prospective association between baseline vitamin D and depression risk in early adolescents. Additionally, a male-specific association between vitamin D and depression risk was observed. Our findings support a potential beneficial effect of vitamin D supplementation in reducing depression risk in early adolescents.

show abstract

Section: Discussionmentioning

confidence: 70%

Vitamin D and depressive symptoms in an early adolescent cohort

Wang

Yuan²,

Chang³

et al. 2022

Psychol. Med.

View full text Add to dashboard Cite

show abstract

“…Out of the 5 studies, 4 evinced statistically significant correlations between vitamin D deficiency and depression, underscoring a promising avenue for further exploration. However, one study Reem Al-Sabah1 et al 19 failed to substantiate any discernible association.…”

Section: Review and Discussionmentioning

confidence: 96%

Vitamin D deficiency and its association with Depression in under 18s: A mysterious relationship of sunlight with darkness

Khan

2024

Preprint

View full text Add to dashboard Cite

Vitamin D receptors are present in areas of the brain involved in mood regulation, such as the hippocampus and prefrontal cortex. It is suggested that Vitamin D may modulate the synthesis and release of neurotransmitters, including serotonin, dopamine, and norepinephrine, which play crucial roles in mood regulation and are implicated in depression. Vitamin D also has anti-inflammatory properties and can influence immune system functioning. Chronic inflammation has been linked to the development of depression. Vitamin D may help regulate the immune response, reducing inflammation and potentially mitigating depressive symptoms. The deficiency of this vitamin has been previously thought to be not as common as recognized now. This review examined multiple studies to investigate the correlation between Vitamin D deficiency and clinical depression in children and adolescents. While numerous studies conducted on adult cohorts have established a plausible association between Vitamin D deficiency and depression, the body of research focused on individuals under the age of 18 remains significantly limited. Drawing from the existing literature, it is imperative for mental health clinicians to uphold a vigilant clinical approach, emphasizing early identification and intervention for the diagnosis and management of Vitamin D deficiency in this demographic.

show abstract

“…A prospective cohort study among 273 children found that those with 25(OH)D levels less than 30 ng/mL (10.3% of participants) at age 5 to 12 years had higher internalizing and externalizing scores after a median follow-up of 6 years. Conversely, a 2022 cross-sectional study among 704 children and adolescents aged 11 to 16 years found no association between 25(OH)D concentration and depressive symptoms.…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D₃ Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years

et al. 2023

View full text Add to dashboard Cite

ImportanceVitamin D is associated with neurodevelopment, but causality, critical windows, and potentials for modification remain unknown.ObjectiveTo determine the impact of high-dose (1200 IU) vs standard-dose (400 IU) vitamin D3 supplementation during the first 2 years on psychiatric symptoms at ages 6 to 8 years and whether the impact is different in children with lower vs higher maternal vitamin D3 levels; lower vs higher levels were defined as 25-hydroxyvitamin D (25[OH]D) less than 30 ng/mL vs 30 ng/mL or greater.Design, Setting, and ParticipantsThis study was a long-term follow-up of the double-blind randomized clinical trial (RCT) Vitamin D Intervention in Infants (VIDI) conducted at a single center in Helsinki, Finland, at 60 degrees north latitude. Recruitment for VIDI took place in 2013 to 2014. Follow-up data for secondary data analysis were collected 2020 to 2021. VIDI originally included 987 term-born infants; 546 of these individuals participated in the follow-up at ages 6 to 8 years, among whom 346 individuals had data on parent-reported psychiatric symptoms. Data were analyzed from June 2022 to March 2023.InterventionsThere were 169 infants randomized to receive 400-IU and 177 infants randomized to receive 1200-IU oral vitamin D3 supplementation daily from ages 2 weeks to 24 months.Main Outcomes and MeasuresPrimary outcomes were internalizing, externalizing, and total problems scores, with clinically significant problems defined as T scores of 64 or greater in the Child Behavior Checklist questionnaire.ResultsAmong 346 participants (164 females [47.4%]; mean [SD] age, 7.1 [0.4] years), the vitamin D3 dose was 400 IU for 169 participants and 1200 IU for 177 participants. Clinically significant internalizing problems occurred in 10 participants in the 1200-IU group (5.6% prevalence) compared with 20 participants (11.8%) in the 400-IU group (odds ratio, 0.40; 95% CI, 0.17-0.94; P = .04) after adjustment for sex, birth season, maternal depressive symptoms at birth, and parental single status at follow-up. In a post hoc subgroup analysis, 48 children in the 400-IU group with maternal 25(OH)D concentrations less than 30 ng/mL had higher internalizing problems scores compared with children in the 1200-IU group, including 44 children with maternal 25(OH)D concentrations below 30 ng/mL (adjusted mean difference, 0.49; 95% CI, 0.09-0.89; P = .02) and 91 children with maternal concentrations above 30 ng/mL (adjusted mean difference, 0.37; 95% CI, 0.03-0.72; P = .04). Groups did not differ in externalizing or total problems.Conclusions and RelevanceThis randomized clinical trial found that higher-than-standard vitamin D3 supplementation in the first 2 years decreased risk of internalizing problems at ages 6 to 8 years.Trial RegistrationClinicalTrials.gov Identifiers: NCT01723852 (VIDI) and NCT04302987 (VIDI2)

show abstract

Vitamin D level in relation to depression symptoms during adolescence

Cited by 11 publications

References 80 publications

Vitamin D and depressive symptoms in an early adolescent cohort

Vitamin D and depressive symptoms in an early adolescent cohort

Vitamin D deficiency and its association with Depression in under 18s: A mysterious relationship of sunlight with darkness

Effect of Vitamin D₃ Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years

Contact Info

Product

Resources

About

Vitamin D level in relation to depression symptoms during adolescence

Cited by 11 publications

References 80 publications

Vitamin D and depressive symptoms in an early adolescent cohort

Vitamin D and depressive symptoms in an early adolescent cohort

Vitamin D deficiency and its association with Depression in under 18s: A mysterious relationship of sunlight with darkness

Effect of Vitamin D3 Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years

Contact Info

Product

Resources

About

Effect of Vitamin D₃ Supplementation in the First 2 Years of Life on Psychiatric Symptoms at Ages 6 to 8 Years