Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: a randomized double-blind placebo-controlled trial

Asadi, Mojgan; Matin, Nassim; Frootan, Mitra; Mohamadpour, Jaleh; Qorbani, Mostafa; Tanha, Fatemeh Davari

doi:10.1007/s00404-013-3055-x

Cited by 59 publications

(37 citation statements)

References 30 publications

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“…Vitamin D treatment may also directly promote growth of the follicle by increasing granulosa cell numbers based upon its ability to induce proliferation in other cell types. For example, vitamin D was shown to induce endometrial cell proliferation in women with polycystic ovarian syndrome (PCOS) during intrauterine insemination cycles (21). …”

Section: Discussionmentioning

confidence: 99%

Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid, and antimüllerian hormone production

Hennebold

Seifer

2016

Fertility and Sterility

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Objective To investigate the direct actions of active 1,25-dihydroxy vitamin D3 (VD3) upon primate follicular development at specific stages of folliculogenesis. Design Secondary preantral follicles were isolated from rhesus monkeys ovaries, encapsulated in alginate, and cultured for 40 days. Follicles were randomly assigned to experimental groups of control, low-dose VD3 (LVD3; 25 pg/ml), and high-dose VD3 (HVD3; 100 pg/ml). Setting National primate research center. Animals Adult, female rhesus macaques (Macaca mulatta). Intervention(s) None. Main Outcome Measure(s) Follicle survival and growth, as well as oocyte size were assessed. Progesterone (P4), androstenedione (A4), estradiol (E2), and anti-Müllerian hormone (AMH) concentrations in culture media were measured. Results Compared with the control group, LVD3 increased preantral follicle survival at week 2 by > 66%, while HVD3 increased antral follicle diameters at week 5. Follicles with diameters ≥ 500 µm at week 5 were categorized as fast-growing follicles. Higher percentages of fast-growing follicles were obtained following HVD3 treatment. Although P4, A4, and E2 production by antral follicles were not altered by VD3, AMH concentrations were 36% higher in LVD3 group relative to controls at week 5. Oocytes with larger diameters were retrieved from antral follicles developed in both LVD3 and HVD3 groups compared with controls. Conclusion The addition of low-dose VD3 increased preantral follicle survival and maintained AMH production by antral follicles, while high-dose VD3 improved antral follicle growth. VD3 supplement promoted oocyte growth in in vitro-developed follicles. Direct actions of VD3 on the primate follicle appear to be both dose- and stage-dependent.

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Section: Discussionmentioning

confidence: 99%

Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid, and antimüllerian hormone production

Hennebold

Seifer

2016

Fertility and Sterility

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“…The intake of VD has been shown to improve the thickness of the endometrium in polycystic ovarian syndrome (PCOS) women but not the probability of pregnancy. Unfortunately, no molecular mechanism explaining this phenomenon was proposed [35]. Interestingly, while different hormonal pathways such as insulin and thyroid hormone signaling pathways have been shown to be dysregulated in the endometrium from assited reproductive technology (ART) patients, the hormonal stimulation treatment does not seem to change the VD pathway at least in terms of VDR expression [36].…”

Section: Vitamin D and Normal Endometriummentioning

confidence: 99%

Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research

Cermisoni

Alteri

Corti

et al. 2018

IJMS

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Growing evidence supports a role of vitamin D (VD) in reproductive health. Vitamin D receptor (VDR) is expressed in the ovary, endometrium, and myometrium. The biological actions of VD in fertility and reproductive tissues have been investigated but mainly using animal models. Conversely, the molecular data addressing the mechanisms underlying VD action in the physiologic endometrium and in endometrial pathologies are still scant. Levels of VDR expression according to the menstrual cycle are yet to be definitively clarified, possibly being lower in the proliferative compared to the secretory phase and in mid-secretory compared to early secretory phase. Endometrial tissue also expresses the enzymes involved in the metabolism of VD. The potential anti-proliferative and anti-inflammatory effects of VD for the treatment of endometriosis have been investigated in recent years. Treatment of ectopic endometrial cells with 1,25(OH)2D3 could significantly reduce cytokine-mediated inflammatory responses. An alteration of VD metabolism in terms of increased 24-hydroxylase mRNA and protein expression has been demonstrated in endometrial cancer, albeit not consistently. The effect of the active form of the vitamin as an anti-proliferative, pro-apoptotic, anti-inflammatory, and differentiation-inducing agent has been demonstrated in various endometrial cancer cell lines.

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“…[71][72][73][74][75][76][77][78][79][80][81][82][83][84] Meanwhile, recent meta-analyses of supplementation studies could not support a therapeutic effect of vitamin D treatment on metabolic disorders of the syndrome, [85][86][87] apart from its positive effect on the reduction of serum triglycerides. 88 In terms of hyperandrogenism markers, one meta-analysis con-IR.…”

Section: (D) Interventional Studies and Pcosmentioning

confidence: 99%

Vitamin D and aspects of female fertility

Voulgaris

Papanastasiou

Piaditis

et al. 2017

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The role of vitamin D in female reproduction has been intensively examined over the last few decades. A large body of evidence suggests that vitamin D might have beneficial effects on metabolic/hormonal parameters of PCOS and endometriosis, while it appears to be associated with IVF outcomes. However, due to the heterogeneity among observational and interventional studies, no cause-effect relationship has yet been established. The aim of this review is to analyze recent in vitro animal and human studies which examined the association of vitamin D with disease entities affecting female fertility potential. Recent research data strongly imply that vitamin D is implicated in female reproduction and might represent a beneficial and inexpensive therapeutic approach, in combination with first-line medical treatments, to female infertility.

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Vitamin D improves endometrial thickness in PCOS women who need intrauterine insemination: a randomized double-blind placebo-controlled trial

Abstract: It seems that administration of vitamin D induces endometrial proliferation in PCOS women during IUI cycle. The study was recorded in Iranian Registry of Clinical Trials(IRCT201104216246N1).

Cited by 59 publications

References 30 publications

Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid, and antimüllerian hormone production

Direct vitamin D3 actions on rhesus macaque follicles in three-dimensional culture: assessment of follicle survival, growth, steroid, and antimüllerian hormone production

Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research

Vitamin D and aspects of female fertility

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