Vitamin D and aspects of female fertility

Voulgaris, N.; Papanastasiou, Labrini; Piaditis, George; Angelousi, Anna; Kaltsas, Gregory; Mastorakos, George; Kassi, Eva

doi:10.14310/horm.2002.1715

Cited by 31 publications

(26 citation statements)

References 134 publications

(122 reference statements)

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“…The results of studies carried out by Brzozowska et al [7] showed a low concentration of 25 (OH) D in the serum of women with PCOS, which suggests that vitamin D3 deficiency may be one of the factors predisposing to polycystic ovary syndrome. Similar conclusions were drawn by Voulgaris et al [8], who observed that women with PCOS had significantly lower levels of vitamin D3 compared to healthy women. Additionally, among the female population with PCOS, obese women showed lower vitamin D levels than those who were overweight or lean.…”

Section: Polycystic Ovary Syndrome (Pcos)supporting

confidence: 89%

“…The characteristic symptoms are: [6] • Increased production of ovarian and adrenal androgens • Acne and hirsutism • Irregular periods • Ultrasound image of polycystic ovaries • Insulin resistance • Hyperinsulinemia • Fertility disorders More and more is said about the correlation between the occurrence of polycystic ovary syndrome and infertility and an increased frequency of miscarriages [6]. The observations carried out show that vitamin D is associated with various metabolic and reproductive features of PCOS, which suggests that it may be involved in the pathogenesis of the syndrome [8]. It is possible that these symptoms may be related to disturbances in calcium metabolism.…”

Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

“…Most women struggling with PCOS are overweight or obese, which is associated with lower levels of vitamin D3 in the plasma of these patients, mainly due to lipophilic vitamin sequestration in adipose tissue, as well as lower exposure of obese people to sunlight [8]. The results of studies carried out by Brzozowska et al [7] showed a low concentration of 25 (OH) D in the serum of women with PCOS, which suggests that vitamin D3 deficiency may be one of the factors predisposing to polycystic ovary syndrome.…”

Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

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Pleiotropic effects of vitamin D3

Egierska

Pietruszka

Burzyńska

et al. 2021

J Educ Health Sport

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Introduction: Vitamin D belongs to the group of fat-soluble vitamins. cholecalciferol (D3) and ergocalciferol (D2) are the most important forms. Vitamin D is associated with a regulatory role in calcium and phosphate metabolism. In recent years, there has been attention to its pleiotropic action. Aim: The aim of the study was to present the general characteristics of vitamin D and explore its relation with polycystic ovary syndrome (PCOS), endometriosis, pain management, insulin resistance, influenza and chronic kidney disease (CKD).Description: VDR receptor has been detected in the cells of the intestines, bones, kidneys, heart, brain, prostate, breast, ovaries, skin. In the ovaries, vit. D3 affects the production of progesterone, estradiol or estrone which suggest its important role in the folliculogenesis and ovulation. Women with PCOS have significantly lower levels of vitamin D3 compared to healthy women. It has been suggested that the deficiency of this vitamin may be related to infertility. Research show that vit. D3 may affect the mechanisms of the inflammatory and nocyceptive pain perception. A significant connection has also been found between vit. D3 and the metabolism of the adipose tissue and insulin secretion. Vitamin D3 deficiency may increase the risk of development of obesity and insulin resistance as well as CKD.Summary: The observation of statistically significant correlation between the reduced level of vit. D3 and occurrence of numerous diseases indicates the need for further research to explain the mechanisms in which D3 deficiency may contribute to development of these diseases. This knowledge is important for the development of new prevention and treatment methods of the diseases mentioned in this article.

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Section: Polycystic Ovary Syndrome (Pcos)supporting

confidence: 89%

Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

Section: Polycystic Ovary Syndrome (Pcos)mentioning

confidence: 99%

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Pleiotropic effects of vitamin D3

Egierska

Pietruszka

Burzyńska

et al. 2021

J Educ Health Sport

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“…Vitamin D deficiency, which arises due to insufficient exposure to sunlight and dermal synthesis from 7-dehydrocholesterol and limited intake from food and supplements, disrupts the function of all systems of the body and increases the risk of osteoporosis, cancer, cardiovascular disease, autoimmune disease, and mental disorders such as depression and chronic pain syndrome [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Relationship between Vitamin D Status and the Menstrual Cycle in Young Women: A Preliminary Study

Łagowska

2018

Nutrients

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Background: The aim of this study was to evaluate serum vitamin D levels and to compare these with the menstrual cycle in young women with different body weights. Methods: Eighty-four students were recruited into the study of which 77 remained at the study’s completion. Women were assigned to one of two subgroups, according to their 25-hydroxy vitamin D test level [25(OH)D] in which 60 women had low 25(OH)D levels (LD < 30 ng/mL) and 17 had normal levels (ND > 30 ng/mL ≤ 80 ng/mL). Results: In the LD group, 40% of participants reported having long cycles, 27% were classified as having oligomenorrhoea, and 13% as having amenorrhoea. In the ND group, only 12% reported menstrual cycle disorders, 6% had oligomenorrhoea, and 6% had amenorrhoea. Women who did not meet the recommended level of 30 ng/mL of 25(OH)D had almost five times the odds of having menstrual cycle disorders as women who were above the recommended vitamin D level. Conclusion: A relationship was demonstrated between the frequency of menstrual disorders and low levels of vitamin D. Supplementation is necessary in women with low levels of vitamin D in order to compensate for this deficiency and to assess its effect in regulating menstrual disorders.

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“…More recently, a regulatory role for vitamin D has been suggested in female fertility 3 , 4 . In this context, previous epidemiological investigations have proposed a seasonality in female reproductive capacity which might be explained partially by seasonal variation in serum levels of vitamin D 5 . Biological activities of vitamin D are applied through the vitamin D receptors (VDR) that have been detected in the ovary especially in granulosa cells and theca cells, endometrium and placenta 6 .…”

Section: Introductionmentioning

confidence: 93%

A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

Karimi

Arab

Rafiee

et al. 2021

Sci Rep

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It is hypothesized that vitamin D deficiency could be related to ovarian reserve. This systematic review and meta-analysis was undertaken to analyze the possible association between vitamin D and ovarian reserve among adolescent and adult women. All eligible studies identified through the ISI Web of Science, PubMed, and Scopus were included up to May 2021. A random-effects meta-analysis model was implemented and a weighted mean difference (WMD) and 95% confidence interval (CI) were calculated. A total of 38 papers covering 8608 individuals were enrolled in this systematic review and meta-analysis. Antral follicle count (AFC) was significantly lower among Asians (WMD − 0.65; 95% CI − 1.28 to − 0.01; P = 0.04; I2 = 0.0%) and luteinizing hormone (LH) levels were higher in non-Asians (WMD 2.16 IU/L; 95% CI 0.20 to 4.12; P = 0.031; I2 = 9.3%) with vitamin D insufficiency/deficiency. Also, there was a negative correlation between vitamin D and LH/FSH ratio in women with normal body mass index (BMI) (Fisher’s Z: − 0.18; 95% CI − 0.37 to − 0.008; P = 0.041; I2 = 51.5%). Although there were no significant associations between serum vitamin D levels and any of the intended ovarian reserve markers, subgroup analyses have found significant findings regarding AFC, LH, and LH/FSH ratio. In order to understand the underlying mechanisms of vitamin D in female reproduction, further attempts are needed.

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Vitamin D and aspects of female fertility

Cited by 31 publications

References 134 publications

Pleiotropic effects of vitamin D3

Pleiotropic effects of vitamin D3

The Relationship between Vitamin D Status and the Menstrual Cycle in Young Women: A Preliminary Study

A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

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