Blood derivates, such as platelet-rich plasma (PRP) and platelet-rich fibrin (PRF), are autogenous sources of many growth factors that are involved in the healing and regeneration of tissues, and for this reason, are used in dentistry treatments. This fact also contributes to the growing interest in these biomaterials in regenerative personalized medicine. The multitude of platelet-rich forms creates many possibilities for their use. This semi-systematic review describes and compares the methods of obtaining properties and potential uses of these materials in personalized treatments.

Introduction: Vitamin D belongs to the group of fat-soluble vitamins. cholecalciferol (D3) and ergocalciferol (D2) are the most important forms. Vitamin D is associated with a regulatory role in calcium and phosphate metabolism. In recent years, there has been attention to its pleiotropic action. Aim: The aim of the study was to present the general characteristics of vitamin D and explore its relation with polycystic ovary syndrome (PCOS), endometriosis, pain management, insulin resistance, influenza and chronic kidney disease (CKD).Description: VDR receptor has been detected in the cells of the intestines, bones, kidneys, heart, brain, prostate, breast, ovaries, skin. In the ovaries, vit. D3 affects the production of progesterone, estradiol or estrone which suggest its important role in the folliculogenesis and ovulation. Women with PCOS have significantly lower levels of vitamin D3 compared to healthy women. It has been suggested that the deficiency of this vitamin may be related to infertility. Research show that vit. D3 may affect the mechanisms of the inflammatory and nocyceptive pain perception. A significant connection has also been found between vit. D3 and the metabolism of the adipose tissue and insulin secretion. Vitamin D3 deficiency may increase the risk of development of obesity and insulin resistance as well as CKD.Summary: The observation of statistically significant correlation between the reduced level of vit. D3 and occurrence of numerous diseases indicates the need for further research to explain the mechanisms in which D3 deficiency may contribute to development of these diseases. This knowledge is important for the development of new prevention and treatment methods of the diseases mentioned in this article.

Sweeteners are widespread primarily in the food industry. An attractive alternative to sugar. Their prevalence was driven primarily by food shortage during the war. The intense sweetener is permitted for consumption by specifying the ratio of ADI. Due to the chemical structure stands out semi-synthetic and synthetic substances. The most common sweeteners are saccharin, acesulfame-K, steviol glycosides, aspartame, xylitol. Sweet taste is guaranteed've been using a minimum amount of their low calorie. The aim of this review was to decribe the most common sweeteners The article emphasizes both advantages and diadvantages of sucrose's substitutes intake.

In the last decade electronic cigarettes also known as e-cigarettes have gained popularity. These are devices designed to imitate regular cigarettes. They provide nicotine via inhalation without using tabacco. The introduction of alternative nicotine delivery devices to the consumer market has inspired a vivid debate on the harmfulness of these products. It is discussed whether they are regulated, safe and as harmless as it is claimed. The purpose of this article was to describe the chemical composition of the e-cigarettes and its influence on human’s health. The devices contain many various groups of potentially toxic and carcinogenic compounts: carbonyls, volatile organic compounts and nitrosamines. The researchs has shown that e-cigarettes contain significantly lower concentration of those substances than the traditional cigarettes. On the other hand, it should be remembered that scientists still do not know potential long term pathologies caused by the liquids.

Introduction: There are specific differences in physiological and biochemical processes during sleep. Adenosine and melatonin are involved in the regulation of circadian rhythms. During sleep, you can observe the secretion of growth hormone, a reduction in cortisol secretion, and a decrease in muscle tone and blood pressure. Sleep can have a major impact on the development of systemic diseases.Aim of the study: A review of the literature aimed at identifying selected negative factors influencing the quality of sleep and systemic diseases which are related to sleep disorders.State of knowledge: Factors that negatively affect sleep include stress, as well as excessive time spent in front of light-emitting screens. Long-term lack of sleep increases the risk of obesity, diabetes, cardiovascular diseases and psychiatric diseases. Summary: Sleep plays an important role in the proper functioning of the body. Its quality is affected by many factors. Sleep disorders can be both the effect and cause of many diseases. Especially in diagnosing psychiatric diseases, attention should be paid to the occurrence of sleep disorders.