A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

Karimi, Elham; Arab, Arman; Rafiee, Masoumeh; Amani, Reza

doi:10.1038/s41598-021-95481-x

Cited by 7 publications

(4 citation statements)

References 69 publications

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“…This review had some limitations. First, the evaluated articles differed regarding the commercial kits they used for measuring serum vitamin levels (42). Second, many factors, including seasonal differences, sunscreen creams, geographic region, race, skin color, lifestyle, and nutrition, could influence the amount, synthesis, and availabilities of vitamins, and the reviewed studies did not consider all these influencing factors when assessing the relationship between serum level of fat-soluble proteins and POI (43,44).…”

Section: Discussionmentioning

confidence: 99%

TheRelationship Between Fat-Soluble Vitamins and Premature Ovarian Failure: A Systematic Review

Dashti,

Tabriz Nia Tabrizi,

Faal Asl Maleki

et al. 2023

J Nurs Midwifery Sci

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Background: Premature ovarian insufficiency (POI) is a major concern in women's health. It is hypothesized that a deficiency in fat-soluble vitamins might result in POI; however, this relationship has not been extensively evaluated. Objectives: This systematic review was designed to elucidate the relationship between fat-soluble vitamin serum levels and POI. Methods: This systematic review was conducted on international databases, including Scopus, National Library of Medicine (PubMed), and Web of Science (ISI) databases, along with Google Scholar, until June 2022. This review was conducted on case reports, case series, cross-sectional, cohort, and case-control studies (observational studies) published in English and Persian in peer-reviewed journals that assessed the association between serum levels of fat-soluble vitamins and POI. Results: Of the 10,029 retrieved articles, 5 (N = 3,443 subjects) were included in the review. The results of the reviewed articles were inconsistent in terms of the relationship between serum vitamin D and A levels and POI; however, vitamin D binding protein and vitamin A/total cholesterol ratio might be related to POI. Serum vitamin E was associated with POI based on the findings of one study. Discussion: This review showed that the serum levels of fat-soluble vitamins might predict POI. However, there was an insufficient number of studies to document the findings. If approved in further studies, these vitamins and their binding proteins can be evaluated in high-risk POI patients.

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Section: Discussionmentioning

confidence: 99%

TheRelationship Between Fat-Soluble Vitamins and Premature Ovarian Failure: A Systematic Review

Dashti,

Tabriz Nia Tabrizi,

Faal Asl Maleki

et al. 2023

J Nurs Midwifery Sci

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“…Nonetheless, it is noteworthy that some recent studies, including meta-analyses, have reported promising results showing that vitamin D supplementation led to improvement in ovarian reserve metrics in a subgroup of normal or diminished ovarian reserves. There were three recent meta-analyses published between 2020 and 2022, two of which provided evidence that vitamin D supplements lead to improved ovarian reserve levels in a subgroup of non-PCOS women with normal ovulation or diminished ovarian reserves [ 42 , 43 ], and one found that lower AFC was associated with vitamin D insufficiency/deficiency in a subgroup analysis of Asians [ 44 ]. Moridi et al highlighted that 18 cross-sectional studies had discrepant findings regarding an association between serum vitamin D and AMH levels, which is likely due to heterogeneity in study subjects and the complex nonlinear relationship between vitamin D and AMH in the systematic review.…”

Section: The Association Of Vitamin D and Ovarian Reserve Markersmentioning

confidence: 99%

The Associations of Vitamin D with Ovarian Reserve Markers and Depression: A Narrative Literature Review

Jeon

2023

Nutrients

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Since the identification of vitamin D receptors in both the female reproductive tract and the central nervous system, further data have shown that vitamin D is involved in the processes of reproductive and mental health. This paper reviews current research on the associations of vitamin D with ovarian reserve markers and depression and discusses the potential role of vitamin D in their relationships. There have been numerous studies reporting that vitamin D was significantly related to ovarian reserve markers and depression in basic or clinical research, but some observational and interventional clinical studies have shown inconsistent results. Nevertheless, recent meta-analyses of interventional studies have provided promising results showing that vitamin D supplementation significantly improves ovarian reserve metrics, especially in a subgroup of women with normal or diminished ovarian reserve, and decreases depressive symptoms and risk. The demonstration of an association of vitamin D with both ovarian reserve and depression could suggest that vitamin D may be another important key in explaining female reproductive depression. Larger-scale studies in standardized settings will be needed in order to gain further insight into the role of vitamin D in female reproduction and depression.

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“…A recent meta-analysis revealed that vitamin D status influences the ovarian reserve: antral follicle count was significantly lower among Asians, and luteinizing Diagnostics 2023, 13, 3024 2 of 12 hormone (LH) levels were higher in non-Asians with inadequate vitamin D levels. Furthermore, a negative correlation was found between vitamin D and the LH/FSH ratio in women with normal body mass index [17]. In addition, the active form of VD (1,25dihydroxy-vitamin D) stimulates aromatase activity [18].…”

Section: Introductionmentioning

confidence: 98%

Relationship between Serum 25-Hydroxyvitamin D Levels and Hormonal Status in Infertile Women: A Retrospective Study

Kolcsár,

Berecki,

Gáll

2023

Diagnostics

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(1) Background: Infertility is a prevalent issue that affects 10–18% of couples worldwide, and up to 30% in Eastern Europe. Infertility of unknown etiology is one of the most challenging forms of infertility. Vitamin D has recently been extensively studied and researchers are investigating its possible role in ovulation and pregnancy. While the evidence suggests a positive association between vitamin D and ovulation, more research is needed to understand the role that vitamin D plays in ovulation. (2) Methods: In this study, 86 infertile patients were studied retrospectively in a single center by analyzing their anthropometric (body mass index), biochemical (total cholesterol, insulin resistance) and hormonal data in correlation with their vitamin D status. (3) Results: It was found that the mid-luteal progesterone level was significantly related to the 25-hydroxy vitamin D level in a multivariate linear regression model. An analysis of subgroups of ovulatory and anovulatory patients suggests that serum 25-hydroxy vitamin D levels of approximately 20 ng/mL may be necessary to trigger ovulation or to support progesterone secretion. (4) Conclusions: Vitamin D deficiency should be considered when infertility of unknown etiology and progesterone-related disorders occur.

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A systematic review and meta-analysis of the association between vitamin D and ovarian reserve

Cited by 7 publications

References 69 publications

TheRelationship Between Fat-Soluble Vitamins and Premature Ovarian Failure: A Systematic Review

TheRelationship Between Fat-Soluble Vitamins and Premature Ovarian Failure: A Systematic Review

The Associations of Vitamin D with Ovarian Reserve Markers and Depression: A Narrative Literature Review

Relationship between Serum 25-Hydroxyvitamin D Levels and Hormonal Status in Infertile Women: A Retrospective Study

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