Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research

Cermisoni, Greta Chiara; Alteri, Alessandra; Corti, Laura; Rabellotti, Elisa; Papaleo, Enrico; Viganò, Paola; Sánchez, Ana M.

doi:10.3390/ijms19082320

Cited by 38 publications

(31 citation statements)

References 70 publications

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“…The endometrium undergoes proliferation, differentiation, and finally degeneration during a normal female menstrual cycle, which is primarily regulated by modifications to estrogen and progesterone concentrations [14]. CYP19, a key regulator of estrogen synthesis, is a rate-determining molecule that activates the reaction turning testosterone into estradiol [15].…”

Section: Introductionmentioning

confidence: 99%

Characterization of VDR and CYP27B1 expression in the endometrium during the menstrual cycle before embryo transfer: implications for endometrial receptivity

Guo

Liu

Wang

et al. 2020

Reprod Biol Endocrinol

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Background: Molecular analyses of vitamin D in a typical cycling endometrium has received minimal research attention in the reproductive field. This study was designed to assess how expression of the endometrial vitamin D receptor (VDR) and CYP27B1, a vitamin D metabolizing enzyme, change during the menstrual cycle in women of reproductive age. In addition, this study explores the association between expression of vitamin D-VDR system and endometrial receptivity during the implantation window. Methods: Sixteen patients underwent standardized in vitro fertilization (IVF) treatment and freeze-all techniques. Before embryo transfer, total serum 25(OH) D levels were determined through blood samples and VDR, CYP27B1, HOXA10, and CYP19 expression were determined through endometrial samples. Endometrial receptivity was also assessed using an electron microscope. Results: We found that VDR protein expression was significantly lower throughout the endometrial secretory phase compared to the proliferative phase, while CYP27B1 expression remained constant during the menstrual cycle. During the implantation window, ultrastructural evaluation showed that higher serum vitamin D levels were associated with more mature pinopodes; VDR and HOXA10 protein expression were substantially elevated in pregnant women compared to non-pregnant women; and VDR protein levels were positively correlated with HOXA10 levels. In addition, serum vitamin D levels were positively correlated with VDR and HOXA10 protein levels in the endometrium. Conclusions: Women with increased VDR expression in the endometrium, especially during the implantation window of the menstrual cycle, were significantly more likely to be pregnant than women with decreased expression. Our results support the hypothesis that the Vitamin D-VDR system performs a role during the development of endometrial receptivity.

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Section: Introductionmentioning

confidence: 99%

Characterization of VDR and CYP27B1 expression in the endometrium during the menstrual cycle before embryo transfer: implications for endometrial receptivity

Guo

Liu

Wang

et al. 2020

Reprod Biol Endocrinol

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“…Vitamin D has a crucial role in reproductive function and health in the human and animal. In addition, VDR is expressed in the ovary, endometrium and myometrium [19] . However, the available data on the impact of vitamin D on the uterine function is limited.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Vitamin D3 on the Contractile Response of Isolated Rat Uterus

Abozaid

kattawy²

2019

The Medical Journal of Cairo University

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Background: Vitamin D receptors (VDR) are expressed in many reproductive tissues indicating a potential role of vitamin D3-VDR in the regulation of reproductive functions. Nevertheless, the data about the effect of vitamin D 3 in the uterus are scarce. Aim of Study:This study was designed to evaluate the potential effects of vitamin D 3 on spontaneous, KCl-induced and oxytocin-induced contractions in the rat uterus in vitro. Material and Methods:The study was conducted on 10 healthy adult female albino non-pregnant rats. Full-thickness longitudinal muscle strips were dissected from each nonpregnant rat and then myometrial tension was recorded. The strips were mounted vertically in organ baths and exposed to vitamin D3 and different uterotonic agents to delineate the potential action of vitamin D 3 on the rat myometrial contractility. Spontaneous contractions were recorded using mechanical activity recording system. We evaluated the effects of 3 different dosed of vitamin D3 on spontaneous uterine contractions; then on concentrated KCl-induced uterine contractions and oxytocin (OT)-induced uterine contractions. Furthermore, the effects of vitamin D3 on spontaneous uterine contractions pretreated with nifedipine; a voltage-gated L-type Ca 2 + channel antagonist were investigated.Results: Vitamin D3 significantly inhibited the spontaneous uterine contractions in a dose dependent manner. Moreover, vitamin D3 inhibited the uterine contractions whether induced by oxytocin or concentrated KCl. Administration of nifedipine resulted in a significant decline in the force amplitude of spontaneous uterine contractions. In the presence of vitamin D3 , the uterine relaxant effect of nifedipine was significantly augmented. Conclusions:The inhibitory effects of the in vitro administration of vitamin D 3 on rat uterus may yield novel insights into its therapeutic use. Further, it may be recommended to be used as a novel tocolytic agent for preventing unwanted uterine contractions in early pregnancy and relieving pain related to dysmenorrhea.

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“…One mechanism involves response reduction to microbial pathogens via cancelation of IL-1, IL-6, and TNF-alpha production by macrophages [73]. Uterine immune cells, such as dendritic cells, macrophages, and natural killer cells are modulated by vitamin D [74], and vitamin D receptors are expressed in the ovary, endometrium, and myometrium to maintain reproductive health [75].…”

Section: Preterm Deliverymentioning

confidence: 99%

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

Keshavarz¹,

Jandaghi²,

Shafiee³

et al. 2020

Vitamin D Deficiency

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Maternal vitamin D deficiency in pregnancy is a widespread public health concern. Race and ethnicity as biological and cultural factors, respectively, can affect vitamin D status through differences in skin color, sunlight exposure, and dietary intake. Low maternal vitamin D status in pregnancy may affect both mother and fetus adversely. Vitamin D deficiency and insufficiency are linked to a wide variety of adverse pregnancy outcomes such as gestational diabetes, preeclampsia, and preterm delivery. Furthermore, maternal vitamin D deficiency has been linked to several adverse health outcomes in infants and children. The examples include, but not limited to, impaired growth, skeletal problems, and autoimmune diseases such as type 1 diabetes and asthma. This chapter reviews the vitamin D status during pregnancy across different ethnic groups, looking into the adverse pregnancy and child outcomes, followed by a discussion on the association between maternal and child vitamin D status and successful interventions. Strong evidence exists about the association between vitamin D and some health outcomes during pregnancy, while more studies are needed to confirm the other claim. The existing body of evidence justifies the need for well-designed policies and systematic interventions to ensure optimal vitamin D status of pregnant women and their offsprings across different ethnic and racial groups.

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Vitamin D and Endometrium: A Systematic Review of a Neglected Area of Research

Cited by 38 publications

References 70 publications

Characterization of VDR and CYP27B1 expression in the endometrium during the menstrual cycle before embryo transfer: implications for endometrial receptivity

Characterization of VDR and CYP27B1 expression in the endometrium during the menstrual cycle before embryo transfer: implications for endometrial receptivity

The Effect of Vitamin D3 on the Contractile Response of Isolated Rat Uterus

Maternal Vitamin D Status among Different Ethnic Groups and Its Potential Contribution to Adverse Pregnancy and Child Outcomes

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