Vitamin D deficiency in UK South Asian Women of childbearing age: a comparative longitudinal investigation with UK Caucasian women

Darling, A. L.; Hart, K.; Macdonald, H; Horton, Khim; Kang’ombe, AR; Berry, J. L.; Lanham-New, Susan A

doi:10.1007/s00198-012-1973-2

Cited by 90 publications

(117 citation statements)

References 42 publications

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“…Meanwhile, South Asian women living in the UK reportedly have lower 25(OH)D levels than do Caucasian women, and the suggested cause is lower sun exposure in Asians than in Caucasians, rather than dietary reasons. 23 Although 25(OH)D levels are reportedly inversely correlated with BMI in Caucasians, 20 we did not observe this relationship in our study. Further study is needed to determine the reasons underlying the lower serum vitamin D status found in our subjects.…”

Section: Discussioncontrasting

confidence: 53%

Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39–64 Years

et al. 2016

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Low serum 25-hydroxyvitamin D (25(OH)D) levels are implicated as a risk factor for hip and spine fractures. Studies of the relation between 25(OH)D levels and fractures have primarily involved elderlyosteoporosis patients or patients with fractures; however, the serum 25(OH)D and parathyroid hormone (PTH) status in younger adult populations remains largely unknown. We evaluated serum 25(OH)D and intact PTH levels in 411 women aged 39-64 years who were not receiving medication for osteoporosis or other bone diseases. Serum 25(OH)D levels were positively correlated with age (P = 0.019), whereas intact PTH levels were inversely correlated with 25(OH)D levels (P < 0.001). Thus, low vitamin D levels with high intact PTH levels were more common in younger than in older women. Our data show that serum 25(OH)D insufficiency could be a more serious concern in the younger population than had been previously anticipated. Because serum 25(OH)D insufficiency is reportedly a risk factor for hip and spine fracture, the number of fracture patients could increase in the future, suggesting that we may need to correct the serum vitamin D/intact PTH status to prevent future osteoporosis.

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Section: Discussioncontrasting

confidence: 53%

Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39–64 Years

et al. 2016

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“…Season (3,5,6) . This is demonstrated in 56 the NDNS data of sex-combined 11-18 year old adolescents, whose mean plasma 25(OH)D…”

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confidence: 99%

Vitamin D in adolescence: evidence-based dietary requirements and implications for public health policy

et al. 2017

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“…(1,2) Hypo-vitaminosis D is prevalent in the UK and our D-FINES study has shown vitamin D deficiency to be more common in South Asian (SA) women than Caucasian (CA) women living in South England (3) . The aim of this study was to investigate the relationship between dietary vitamin D and calcium (Ca) intakes, vitamin D status and bone health indices among the women who took part in our D2-D3 study.…”

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confidence: 99%

Associations between Baseline Vitamin D Status, Dietary Intake of Vitamin D and Calcium on Bone Health in Caucasian and South Asian Women: Further analysis of the D2-D3 Study

et al. 2016

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Vitamin D deficiency results in osteomalacia and leads to osteoporosis.(1,2) Hypo-vitaminosis D is prevalent in the UK and our D-FINES study has shown vitamin D deficiency to be more common in South Asian (SA) women than Caucasian (CA) women living in South England (3) . The aim of this study was to investigate the relationship between dietary vitamin D and calcium (Ca) intakes, vitamin D status and bone health indices among the women who took part in our D2-D3 study. The D2-D3 study was a vitamin D RCT previously reported (4) in which vitamin D status was measured by LC/MS and 4d food diaries were used to measure dietary intake. The specific cross-sectional analysis was on the baseline data of 260 women and the longitudinal analysis on 59 women in the placebo group.Mean dietary vitamin D intakes in SA and CA women were 2·24 ± 2·0, 2·78 ± 2·3 µg, respectively. Mean dietary Ca intakes were 870 ± 261·5 mg in Caucasians and 703·5 ± 211·5 mg in South Asians. Vitamin D status of Caucasians (60·21 ± 25·6 nmol/l) was much higher than that of Asians (21·7 ± 18·1 nmol/l), (P < 0·001). Body weight and body fat in Asians and BMI in Caucasians were negatively correlated with serum 25-hydroxyvitamin D status (25OHD) (P < 0·05). In SA women, higher vitamin D intake was associated with higher vitamin D status (lowest vitamin D intake T1, 25(OH)D 16·35 nmol/l to highest vitamin D intake T3, 25(OH)D 35·08 nmol/l; F test for linearity, P = 0·017), remaining significant after adjusting for age and body size (P < 0·01).

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Vitamin D deficiency in UK South Asian Women of childbearing age: a comparative longitudinal investigation with UK Caucasian women

Cited by 90 publications

References 42 publications

Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39–64 Years

Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39–64 Years

Vitamin D in adolescence: evidence-based dietary requirements and implications for public health policy

Associations between Baseline Vitamin D Status, Dietary Intake of Vitamin D and Calcium on Bone Health in Caucasian and South Asian Women: Further analysis of the D2-D3 Study

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