Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39–64 Years

Miyamoto, Takeshi; Katsuyama, Eri; Kanagawa, Hiroya; Fujie, Atsuhiro; Miyamoto, Hiroaki; Yoshida, Shigeyuki; Mori, Tomoaki; Miyamoto, Kana; Sato, Yuiko; Kobayashi, Tami; Nakamura, Masaya; Matsumoto, Morio; Nishiwaki, Yuji; Hara, Hiroshi; Kanda, Takeshi; Saito, Ikuo; Toyama, Yoshiaki

doi:10.2302/kjm.2015-0010-oa

Cited by 13 publications

(11 citation statements)

References 24 publications

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“…At present, why the LL group showed such great variation in PTH levels, as reflected by high SDs is not clear. PTH levels are reportedly inversely correlated with those of vitamin D ( Miyamoto et al, 2016 ; Garnero et al, 1996 ), and inverse correlation between the two was observed in our subjects, including in the LL group ( Table 2 ). Low vitamin D levels, as indicated by 25(OH)D values lower than 30 ng/ml, were seen in all groups ( Table 1 ).…”

Section: Resultssupporting

confidence: 64%

“…However, 25(OH)D levels were not associated with either TRACP5b or BMD values in any group or in the total population ( Table 3 ). Moreover, low vitamin D levels are often seen in the general population, even in people under 40 years old ( Miyamoto et al, 2016 ), as well as in our subjects. Thus, our metabolomics data may reflect general trends.…”

Section: Resultssupporting

confidence: 56%

“…Subjects were female employees of the Keio University School of Medicine, aged 39–61 years, who had undergone medical examination in September of 2013 ( Miyamoto et al, 2017 ; Miyamoto et al, 2016 ) or who had visited our hospital as possible patients. Written informed consent was obtained from all subjects.…”

Section: Methodsmentioning

confidence: 99%

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Metabolomics-based profiles predictive of low bone mass in menopausal women

et al. 2018

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Osteoporosis is a skeletal disorder characterized by compromised bone strength and increased risk of fracture. Low bone mass and/or pre-existing bone fragility fractures serve as diagnostic criteria in deciding when to start medication for osteoporosis. Although osteoporosis is a metabolic disorder, metabolic markers to predict reduced bone mass are unknown. Here, we show serum metabolomics profiles of women grouped as pre-menopausal with normal bone mineral density (BMD) (normal estrogen and normal BMD; NN), post-menopausal with normal BMD (low estrogen and normal BMD; LN) or post-menopausal with low BMD (low estrogen and low BMD; LL) using comprehensive metabolomics analysis. To do so, we enrolled healthy volunteer and osteoporosis patient female subjects, surveyed them with a questionnaire, measured their BMD, and then undertook a comprehensive metabolomics analysis of sera of the three groups named above. We identified 24 metabolites whose levels differed significantly between NN/LN and NN/LL groups, as well as 18 or 10 metabolites whose levels differed significantly between NN/LN and LN/LL, or LN/LL and NN/LN groups, respectively. Our data shows metabolomics changes represent useful markers to predict estrogen deficiency and/or bone loss.

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Section: Resultssupporting

confidence: 64%

Section: Resultssupporting

confidence: 56%

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Metabolomics-based profiles predictive of low bone mass in menopausal women

et al. 2018

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“…Accordingly, vitamin D deficiency is frequently seen in the elderly 43 , 44 . However, young people are equally vulnerable to low vitamin D status 45 – 47 , making vitamin D deficiency a general concern.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice

Nakamura

Sato

Kobayashi

et al. 2020

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Vitamin D deficiency is a recognized risk factor for sarcopenia development, but mechanisms underlying this outcome are unclear. Here, we show that low vitamin D status worsens immobilization-induced muscle atrophy in mice. Mice globally lacking vitamin D receptor (VDR) exhibited more severe muscle atrophy following limb immobilization than controls. Moreover, immobilization-induced muscle atrophy was worse in neural crest-specific than in skeletal muscle-specific VDR-deficient mice. Tnfα expression was significantly higher in immobilized muscle of VDR-deficient relative to control mice, and was significantly elevated in neural crest-specific but not muscle-specific VDR-deficient mice. Furthermore, muscle atrophy induced by limb immobilization in low vitamin D mice was significantly inhibited in Tnfα-deficient mice. We conclude that vitamin D antagonizes immobilization-induced muscle atrophy via VDR expressed in neural crest-derived cells.

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“…Taking low dose pills reportedly increases bone mineral density (BMD) 10 , but hormone replacement therapy is associated with an increased risk of stroke and venous thromboembolism 11 . Vitamin D also regulates bone metabolism 12 , and low vitamin D status is reportedly a risk factor for fragility fractures 13,14 . Low vitamin D levels are also associated with stress injuries 15,16 , and Vitamin D supplementation reportedly decreases occurrence of stress fracture 17 .…”

Section: Introductionmentioning

confidence: 99%

Elevated Creatine Kinase and Lactic Acid Dehydrogenase and Decreased Osteocalcin and Uncarboxylated Osteocalcin are Associated with Bone Stress Injuries in Young Female Athletes

Miyamoto

Oguma

Sato

et al. 2018

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Stress fractures are a limitation for athletes not only in sports performance but in activities of daily living. Thus, preventing them is crucial. In female athletes, a triad of symptoms including low energy availability, functional hypothalamic amenorrhea and osteoporosis are considered risk factors for stress injuries, but biomarkers predictive of these outcomes are not available. Here, we evaluated 56 female university athletes and found that 13 had a history of stress bone injuries. Logistic regression analysis demonstrated that dysmenorrhea including amenorrhea, but not reduced food intake or body weight loss, was significantly associated with stress injuries. When we subdivided subjects into stress fracture and non-fracture groups, we found that serum levels of creatine kinase (CK) and lactic acid dehydrogenase (LDH) were significantly higher in the fracture group, while osteocalcin and uncarboxylated osteocalcin (ucOC), which are bone forming parameters, significantly decreased. Low vitamin D levels are associated with stress fractures, but serum vitamin D levels were higher in fracture compared to non-fracture subjects. We followed up 32 subjects for one year, and three exhibited new stress injuries during that period. A history of stress fracture history is significantly associated with experiencing a new stress fracture. We also found that subjects with new fracture performed significantly greater exercise activity than did non-fracture subjects. Taken together, our data indicate that increased serum CK and LDH and decreased serum osteocalcin and ucOC are biomarkers of stress injuries, and evaluating these markers along with dysmenorrhea, stress fracture history or high sports activity could predict future stress fractures in female athletes.

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Vitamin D Deficiency with High Intact PTH Levels is More Common in Younger than in Older Women: A Study of Women Aged 39–64 Years

Cited by 13 publications

References 24 publications

Metabolomics-based profiles predictive of low bone mass in menopausal women

Metabolomics-based profiles predictive of low bone mass in menopausal women

Vitamin D protects against immobilization-induced muscle atrophy via neural crest-derived cells in mice

Elevated Creatine Kinase and Lactic Acid Dehydrogenase and Decreased Osteocalcin and Uncarboxylated Osteocalcin are Associated with Bone Stress Injuries in Young Female Athletes

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