Vitamin D deficiency in adult tuberculosis patients [Correspondence]

Sc, Arya; Agarwal, Nitin

doi:10.5588/ijtld.11.0113

Cited by 5 publications

(3 citation statements)

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“…High intracellular iron levels are beneficial for M. tuberculosis growth; therefore, this down-regulation would help combat infection. The discovery that vitamin D regulates antimicrobial gene expression has spurred many recent epidemiology studies that have shown a correlation between vitamin D deficiency and increased risk or severity of tuberculosis, supporting similar findings made in the 1980s [30][31][32][33][34][35][36][37][38][39].…”

Section: Recent Findings Elucidate the Antibiotic Mechanism Of Vitamin Dmentioning

confidence: 61%

The Antibiotic Effects of Vitamin D

Guo¹,

Gombart

2014

EMIDDT

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The recent discovery that vitamin D regulates expression of the cathelicidin antimicrobial peptide gene has generated renewed interest in using vitamin D to fight infectious diseases. This review describes the historical use of vitamin D or its sources to treat infections, the mechanism of action through which vitamin D mediates its "antibiotic" effects, findings from epidemiological studies associating vitamin D deficiency with increased susceptibility to infection and clinical trials with vitamin D supplementation to treat or prevent infections. Further studies examining an association between vitamin D levels and cathelicidin expression are discussed. The role of cathelcidin throughout the course of infection from the initial encounter of the pathogen to the resolution of tissue damage and inflammation indicates that individuals need to maintain adequate levels of vitamin D for an optimal immune response. In addition, for treating infections, carefully designed randomized, clinical trials that are appropriately powered to detect modest effects, target populations that are severely deficient in vitamin D,and optimized dose, dosing frequency and safety are needed.

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Section: Recent Findings Elucidate the Antibiotic Mechanism Of Vitamin Dmentioning

confidence: 61%

The Antibiotic Effects of Vitamin D

Guo¹,

Gombart

2014

EMIDDT

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“…Infectious disease such as tuberculosis, upper respiratory tract infections of viral origin, i.e., influenza is seen in individuals with Vitamin D deficiency. [ 59 60 61 ]…”

Section: Consequences Of Vitamin D Deficiencymentioning

confidence: 99%

Vitamin D deficiency in India

Aparna

Nongkynrih

et al. 2018

J Family Med Prim Care

166

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Vitamin D is a fat-soluble vitamin playing a vital role in human physiology. Vitamin D deficiency is prevalent worldwide. This deficiency has many consequences which are still being explored, apart from the well-known skeletal complications. With this review, we aim to summarize the existing literature on Vitamin D status in India and understand the enormity of the problem. The prevalence of Vitamin D deficiency ranged from 40% to 99%, with most of the studies reporting a prevalence of 80%–90%. It was prevalent in all the age groups and high-risk groups alike. With the consequences of Vitamin D deficiency, namely, autoimmune diseases, cardiovascular diseases, cancer, and tuberculosis being explored, we can imagine the burden it would cause in our country. We need to create awareness among the public and healthcare providers about the importance of Vitamin D and the consequences of deficiency. Our Indian diet generally fails to satisfy the daily requirement of Vitamin D for a normal adult. This stresses on the need for fortifying various food with Vitamin D, through the national programs. This silent epidemic should be addressed appropriately with concrete public health action.

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“…In terms of current research results, vitamin D deficiency is also linked with the susceptibility to Mycobacterium tuberculosis ( 4 ). However, a specific mechanism behind this relation is not clear ( 5 ). Therefore, the present study evaluated the influence of vitamin D deficiency on T cell subsets in patients with spinal tuberculosis.…”

Section: Introductionmentioning

confidence: 99%

Influence of vitamin D deficiency on T cell subsets and related indices during spinal tuberculosis

et al. 2018

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The present study investigated the effects of vitamin D deficiency on T cell subsets in patients with spinal tuberculosis. In addition, the influence of vitamin D deficiency was investigated on the expression of cytokines IL-1β, IL-6 and TNF-α in intervertebral disc lesions of patients. One hundred and seventeen patients with spinal tuberculosis who received operative treatment in the Department of Orthopedics in Wuhan City Third Hospital from March 2012 to March 2015 were collected. The patients were divided depending upon vitamin D content into the control group (64 cases, vitamin D content <25 nmol/l) and experimental group (53 cases, vitamin D content >50 nmol/l). Immunofluorescence method was applied to determine the content of T cell subsets in both groups of patients. Intervertebral disc lesion tissues of two groups of patients were obtained during surgery then treated with HE staining and immunohistochemical staining. The values of average optical density obtained under light microscope were observed as the expression quantities of IL-1β, IL-6 and TNF-α, to explore the relationship between vitamin D and the expression of cytokines. When vitamin D is lacking, the expression of T lymphocyte subsets in patients with spinal tuberculosis significantly decreased. Compared with experimental group, the difference was statistically significant (P<0.05). Further, the expression of cytokines IL-1β, IL-6 and TNF-α in intervertebral disc lesion tissues of patients with spinal tuberculosis were significantly higher than those of patients with spinal tuberculosis whose vitamin D content was normal (P<0.05). In the control group, vitamin D content was negatively correlated with the expression of IL-1β, IL-6 and TNF-α. The expression of T lymphocyte subsets in patients with vitamin D deficiency was significantly reduced, and the immune function decreased. The expression of IL-1β, IL-6 and TNF-α in lesions were significantly higher than those of patients with normal vitamin D content. In addition, the lower the content of vitamin D was, the more active the expression of inflammatory factors were, which was not conducive to the recovery of tuberculosis lesions.

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Vitamin D deficiency in adult tuberculosis patients [Correspondence]

Cited by 5 publications

References 0 publications

The Antibiotic Effects of Vitamin D

The Antibiotic Effects of Vitamin D

Vitamin D deficiency in India

Influence of vitamin D deficiency on T cell subsets and related indices during spinal tuberculosis

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