The Antibiotic Effects of Vitamin D

Guo, Cheng; Gombart, Adrian F.

doi:10.2174/1871530314666140709085159

Cited by 17 publications

(13 citation statements)

References 157 publications

(167 reference statements)

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“…Although we have not investigated their possible association with dry eye parameters, vitamin D deficiency probably may have relatiosn with dry eye and impaired tear function, whereas inflammatory factors play a critical role. Additionally, vitamin D is reported to induce cathelicidin, an antimicrobial peptide produced by corneal and conjunctival epithelial cells, and promotes corneal and conjunctival wound healing . These findings provide the evidence that vitamin D may have a role in wound healing of corneal and epithelial cells and may have a protective effect on the development of dry eye.…”

Section: Discussionmentioning

confidence: 64%

Dry eye in vitamin D deficiency: more than an incidental association

et al. 2015

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Section: Discussionmentioning

confidence: 64%

Dry eye in vitamin D deficiency: more than an incidental association

et al. 2015

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“…19 1,25(OH) 2 D mediates the innate immune host response against respiratory tract pathogens by stimulating expression of cathelicidin (hCAP18/LL37), an antimicrobial peptide with activity against viral, bacterial, and fungal pathogens. 20,21 It also regulates the adaptive immune system by modulating T-lymphocyte proliferation and function and by downregulating the inflammatory response and cytokine expression. 22 In addition to these functions of 1,25(OH) 2 D, the parent compound vitamin D itself is a potent and general mediator of endothelial stability and barrier function.…”

Section: Introductionmentioning

confidence: 99%

Randomized phase 2 trial of monthly vitamin D to prevent respiratory complications in children with sickle cell disease

Lee¹,

Kattan

Fennoy³

et al. 2018

Blood Advances

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In sickle cell disease, respiratory infection and asthma may lead to respiratory complications that are a leading cause of morbidity and mortality. Vitamin D has anti-infective and immunomodulatory effects that may decrease the risk for respiratory infections, asthma, and acute chest syndrome. We conducted a randomized double-blind active-controlled clinical trial to determine whether monthly oral vitamin D can reduce the rate of respiratory events in children with sickle cell disease. Seventy sickle cell subjects, ages 3-20 years, with baseline records of respiratory events over 1 year before randomization, underwent screening. Sixty-two subjects with 25-hydroxyvitamin D levels of 5-60 ng/mL were randomly assigned to oral vitamin D (100 000 IU or 12 000 IU, n = 31 each) under observed administration once monthly for 2 years. The primary outcome was the annual rate of respiratory events (respiratory infection, asthma exacerbation, or acute chest syndrome) ascertained by the use of a validated questionnaire administered biweekly. Analysis included 62 children (mean age of 9.9 years, 52% female, and predominantly with homozygous HbS disease [87%]) with mean baseline 25-hydroxyvitamin D of 14.3 ng/mL. The annual rates of respiratory events at baseline and intervention years 1 and 2 were 4.34 ± 0.35, 4.28 ± 0.36, and 1.49 ± 0.37 (high dose) and 3.91 ± 0.35, 3.34 ± 0.37, and 1.54 ± 0.37 (standard dose), respectively. In pediatric patients with sickle cell disease, 2-year monthly oral vitamin D was associated with a >50% reduction in the rate of respiratory illness during the second year ( = .0005), with similar decreases associated with high- and standard-dose treatment. This trial was registered at www.clinicaltrials.gov as #NCT01443728.

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“…39 Specifically, vitamin D was shown to induce expression of cathelicidin, an important antimicrobial peptide that protects the skin against various pathogens, including S. aureus. 40 Vitamin D deficiency could contribute to the increased S. aureus colonization and sepsis, which are both common in advanced CTCL patients. 22,28,41 In addition to infections, various medications were proposed to trigger MF including antihistamines, antiepileptics, antihypertensives (e.g.…”

mentioning

confidence: 99%

Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy

et al. 2016

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Most skin malignancies are caused by external and often preventable environmental agents. Multiple reports demonstrated that cutaneous T-cell lymphomas (CTCL) can occur in married couples and cluster in families. Furthermore, recent studies document geographic clustering of this malignancy in Texas as well as in other areas of the United States. Multiple infectious, occupational, and medication causes have been proposed as triggers or promoters of this malignancy including hydrochlorothiazide diuretics, Staphylococcus aureus, dermatophytes, Mycobacterium leprae, Chlamydia pneumoniae, human T-Cell lymphotropic virus type 1 (HTLV1), Epstein-Barr virus (EBV), and herpes simplex virus (HSV). In this report, we review recent evidence evaluating the involvement of these agents in cancer initiation/progression. Most importantly, recent molecular experimental evidence documented for the first time that S. aureus can activate oncogenic STAT3 signaling in malignant T cells. Specifically, S. aureus Enterotoxin type A (SEA) was recently shown to trigger non-malignant infiltrating T cells to release IL-2 and other cytokines. These signals upon binging to their cognate receptors on malignant T cells are then able to activate STAT3 and STAT5 oncogenic signaling and promote cancer progression and IL-17 secretion. In light of these findings, it might be important for patients with exacerbation of their CTCL symptoms to maintain high index of suspicion and treat these individuals for S. aureus colonization and/or sepsis with topical and systemic antibiotics.

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The Antibiotic Effects of Vitamin D

Cited by 17 publications

References 157 publications

Dry eye in vitamin D deficiency: more than an incidental association

Dry eye in vitamin D deficiency: more than an incidental association

Randomized phase 2 trial of monthly vitamin D to prevent respiratory complications in children with sickle cell disease

Investigating potential exogenous tumor initiating and promoting factors for Cutaneous T-Cell Lymphomas (CTCL), a rare skin malignancy

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