Vitamin D as Supplementary Treatment for Tuberculosis

Wejse, Christian; Gomes, Vera Lúcia de Oliveira; Rabna, Paulo; Gustafson, Per; Aaby, Péter; Lisse, Ida Maria; Andersen, Paul; Glerup, Henning; Sodemann, Morten

doi:10.1164/rccm.200804-567oc

Cited by 337 publications

(147 citation statements)

References 28 publications

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“…Other possible explanations for differences in measured responses of human HIV ϩ macrophages to exogenous 1,25D 3 include differences in host defense gene expression induced by HIV infection, the requirement of TLR or other receptor expression to critical or threshold levels to activate signaling pathways, or differences in activation states of HIV ϩ macrophages compared to macrophages from healthy persons (48), although these were not specifically investigated in the current study. (49,50). Our central observation is that vitamin D pretreatment can rescue defective M. tuberculosis-mediated TNF release in HIV ϩ human macrophages.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Rescues Impaired Mycobacterium tuberculosis-Mediated Tumor Necrosis Factor Release in Macrophages of HIV-Seropositive Individuals through an Enhanced Toll-Like Receptor Signaling PathwayIn Vitro

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Vitamin D Rescues Impaired Mycobacterium tuberculosis-Mediated Tumor Necrosis Factor Release in Macrophages of HIV-Seropositive Individuals through an Enhanced Toll-Like Receptor Signaling PathwayIn Vitro

et al. 2013

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“…Clinical studies on vitamin D supplementation in deficient individuals with active MTb have been disappointing. In a randomized, doubleblind, placebo-controlled trial involving patients with MTb in Guinea-Bissau, supplementation with vitamin D did not lead to an improvement in clinical severity or 12-month mortality (Wejse et al 2009). However, the relevance of this negative result is questionable given that the intervention did not influence participants' vitamin D status.…”

Section: Respiratory Infectionsmentioning

confidence: 99%

An update on the association of vitamin D deficiency with common infectious diseases

Watkins

Lemonovich

Salata

2015

Can. J. Physiol. Pharmacol.

102

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Vitamin D plays an important role in modulating the immune response to infections. Deficiency of vitamin D is a common condition, affecting both the general population and patients in health care facilities. Over the last decade, an increasing body of evidence has shown an association between vitamin D deficiency and an increased risk for acquiring several infectious diseases, as well as poorer outcomes in vitamin D deficient patients with infections. This review details recent developments in understanding the role of vitamin D in immunity, the antibacterial actions of vitamin D, the association between vitamin D deficiency and common infections (like sepsis, pneumonia, influenza, methicillin-resistant Staphylococcus aureus, human immunodeficiency virus type-1 (HIV), and hepatitis C virus (HCV)), potential therapeutic implications for vitamin D replacement, and future research directions.

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“…In one study, high-dose vitamin D supplementation was reported to accelerate clinical and radiological improvement in pulmonary tuberculosis patients [148]. However, others reported no effect [149]. A recent systematic review of randomized, placebo double-blind trials assessing the beneficial of vitamin D administration in patients with multiple sclerosis was unable to reach a verdict with no significant effect seen in 4 out of 5 available trials [150].…”

Section: Link Between Vitamin D and Immune Function - Evidence From Imentioning

confidence: 99%

Vitamin D and Its Effects on Glucose Homeostasis, Cardiovascular Function and Immune Function

et al. 2014

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In recent years there has been increasing interest in the non-skeletal effects of vitamin D. It has been suggested that vitamin D deficiency may influence the development of diabetes, cardiovascular dysfunction and autoimmune diseases. This review focuses on the current knowledge of the effects of vitamin D and its deficiency on cardiovascular function, glucose homeostasis and immune function, with a particular focus on children. Although, there is good evidence to show that there is an association between vitamin D deficiency and an abnormality of the above systems, there is little evidence to show that vitamin D supplementation leads to an improvement in function, especially in childhood.

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Vitamin D as Supplementary Treatment for Tuberculosis

Abstract: Vitamin D does not improve clinical outcome among patients with TB and the trial showed no overall effect on mortality in patients with TB; it is possible that the dose used was insufficient. Clinical trial registered with www.controlled-trials.com/isrctn (ISRCTN35212132).

Cited by 337 publications

References 28 publications

Vitamin D Rescues Impaired Mycobacterium tuberculosis-Mediated Tumor Necrosis Factor Release in Macrophages of HIV-Seropositive Individuals through an Enhanced Toll-Like Receptor Signaling PathwayIn Vitro

Vitamin D Rescues Impaired Mycobacterium tuberculosis-Mediated Tumor Necrosis Factor Release in Macrophages of HIV-Seropositive Individuals through an Enhanced Toll-Like Receptor Signaling PathwayIn Vitro

An update on the association of vitamin D deficiency with common infectious diseases

Vitamin D and Its Effects on Glucose Homeostasis, Cardiovascular Function and Immune Function

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