Vitamin D and Ulcerative Colitis: Is There a Relationship with Disease Extent?

Zammit, Stefania Chetcuti; Schembri, John; Pisani, Anthea; Vella, Sandro; Azzopardi, Matthias; Skamnelos, Alexandros; Christodoulou, Dimitrios; Κατσάνος, Κωνσταντίνος; Ellul, Pierre

doi:10.1159/000494439

Cited by 3 publications

(3 citation statements)

References 45 publications

(50 reference statements)

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“…Vitamin D exerts various anti-inflammatory, antioxidant, immunomodulatory, and antifibrotic effects ( 33 ). Typically, patients with UC have low serum vitamin D levels, which are associated with complications such as low bone mineral density ( 34 – 37 ). The inverse association of vitamin D with IBD or UC disease has been confirmed recently, and vitamin D supplements have been shown to help relieve disease symptoms ( 33 , 36 , 38 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway

Gao

Zhang

et al. 2023

Front. Immunol.

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Inflammation is a key factor in the development of ulcerative colitis (UC). 1,25-dihydroxyvitamin D3 (1,25(OH)2D3, VD3), as the major active ingredient of vitamin D and an anti-inflammatory activator, is closely related to the initiation and development of UC, but its regulatory mechanism remains unclear. In this study, we carried out histological and physiological analyses in UC patients and UC mice. RNA sequencing (RNA-seq), assays for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), chromatin immunoprecipitation (ChIP) assays and protein and mRNA expression were performed to analyze and identify the potential molecular mechanism in UC mice and lipopolysaccharide (LPS)-induced mouse intestinal epithelial cells (MIECs). Moreover, we established nucleotide-binding oligomerization domain (NOD)-like receptor protein nlrp6-/- mice and siRNA-NLRP6 MIECs to further characterize the role of NLRP6 in anti-inflammation of VD3. Our study revealed that VD3 abolished NOD-like receptor protein 6 (NLRP6) inflammasome activation, suppressing NLRP6, apoptosis-associated speck-like protein (ASC) and Caspase-1 levels via the vitamin D receptor (VDR). ChIP and ATAC-seq showed that VDR transcriptionally repressed NLRP6 by binding to vitamin D response elements (VDREs) in the promoter of NLRP6, impairing UC development. Importantly, VD3 had both preventive and therapeutic effects on the UC mouse model via inhibition of NLRP6 inflammasome activation. Our results demonstrated that VD3 substantially represses inflammation and the development of UC in vivo. These findings reveal a new mechanism by which VD3 affects inflammation in UC by regulating the expression of NLRP6 and show the potential clinical use of VD3 in autoimmune syndromes or other NLRP6 inflammasome-driven inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway

Gao

Zhang

et al. 2023

Front. Immunol.

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“… 168 Vitamin D levels were also decreased in UC patients, and the mean vitamin D level was lowest in patients with extensive UC (E3), suggesting a close relationship between disease progression and serum vitamin D level. 169 Furthermore, during periods of clinical UC remission, serum vitamin D levels <35mg/mL could predict the risk of relapse. 170 The ability of low vitamin D status to predict poor IBD outcomes is clarified in a review by Gubatan et al 171 A retrospective study found that 27.5 ng/mL is the optimal cut-off value for vitamin D to define the active and remission phases of IBD.…”

Section: Predictive Role For Vitamin D During Ibdmentioning

confidence: 99%

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Wu¹,

Liu²,

Deng³

2022

JIR

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Inflammatory bowel disease (IBD) is a nonspecific inflammatory disease that includes ulcerative colitis (UC) and Crohn’s disease (CD). The pathogenesis of IBD is not fully understood but is most reported associated with immune dysregulation, dysbacteriosis, genetic susceptibility, and environmental risk factors. Vitamin D is an essential nutrient for the human body, and it not only regulates bone metabolism but also the immune system, the intestinal microbiota and barrier. Vitamin D insufficiency is common in IBD patients, and the abnormal low levels of vitamin D are highly correlated with disease activity, treatment response, and risk of relapse of IBD. Accumulating evidence supports the protective role of vitamin D in IBD through regulating the adaptive and innate immunity, maintaining the intestinal barrier and balancing the gut microbiota. This report aims to provide a broad overview of the role vitamin D in the immune system, especially in the pathogenesis and treatment of IBD, and its possible role in predicting relapse.

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“…In a study done by Zammit et al among the European population, the disease activity index increased with decreased levels of vitamin D [ 22 ]. The study had evaluated disease activity using a simple clinical colitis activity index.…”

Section: Discussionmentioning

confidence: 99%

Association of Vitamin D Level With Disease Severity and Quality of Life in Newly Diagnosed Patients of Ulcerative Colitis: A Cross-Sectional Analysis

Dash¹,

Panda²,

Das³

et al. 2021

Cureus

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IntroductionUlcerative colitis is an immunologically mediated disorder affecting the gastrointestinal tract. Vitamin D3 has been shown to modulate many immunological diseases, but its role in ulcerative colitis is not well documented. This study was done to find out if levels of vitamin D are associated with the severity of disease and quality of life in ulcerative colitis patients. MethodsThis cross-sectional study consists of two parts. The first part consists of having a comparative assessment of baseline parameters of newly diagnosed ulcerative colitis patients and healthy controls. The 2nd part consists of an evaluation of the association of levels of vitamin D3 with disease severity and quality of life in ulcerative colitis. Independent predictors of disease severity and quality of life were assessed using multiple linear regression. ResultsVitamin D levels were significantly lower in healthy controls compared to newly diagnosed ulcerative colitis patients. Median ulcerative colitis disease activity index score was significantly higher in the vitamin D deficient group compared with those who had normal vitamin D levels (p-0.001). Quality of life was also poor in the vitamin D deficient group compared to those with normal vitamin D levels (p-0.000). Vitamin D levels were found to be independent predictors of ulcerative colitis disease activity scores and health-related quality of life scores. ConclusionVitamin D may have some immunomodulating properties, which might be associated with decreased ulcerative colitis disease activity index and better quality of life.

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Vitamin D and Ulcerative Colitis: Is There a Relationship with Disease Extent?

Cited by 3 publications

References 45 publications

Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway

Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Association of Vitamin D Level With Disease Severity and Quality of Life in Newly Diagnosed Patients of Ulcerative Colitis: A Cross-Sectional Analysis

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