The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Wu, Zengrong; Liu, Deliang; Deng, Feihong

doi:10.2147/jir.s363840

Cited by 29 publications

(41 citation statements)

References 171 publications

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“…Existing studies clearly suggest that UC is a group of chronic nonspecific inflammatory diseases of the colon and rectum. According to the current research, the pathogenesis of UC is still unclear, but with the in-depth research of domestic and foreign scholars, it is found that UC may be related to genetics, immunity, susceptibility genes, and environmental factors [ 102 ]. We found that genetic factors play a certain role in the pathogenesis of UC, and psychologically induced factors are also critical in the deterioration of UC.…”

Section: Resultsmentioning

confidence: 99%

Animal Models and Pathogenesis of Ulcerative Colitis

Gao

Pang

et al. 2022

Computational and Mathematical Methods in Medicine

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Background. Ulcerative colitis (UC) is a kind of inflammatory bowel disease which is needed to be predicted. Objective. To analyze various animal models of UC conditions and summarizes the animal selection, model progression, and pathogenic mechanisms of UC animal models. Methods. We surveyed the research papers published in PubMed, Google Scholar, Baidu Scholar, CNKI, SciFinder, and Web of Science in the past 5 years and discussed the experimental animals, modeling methods, and pathogenic mechanisms. Results. In the selection of experimental animals, rats are considered the best experimental animals. The mainstream modeling methods can be categorized into the chemical stimulation method, immune stimulation method, and compound method, among which the compound method is the most successful. In the study of the pathogenesis of UC, the pathogenesis of UC is due to various pathogenic factors, such as nitric oxide (NO), prostaglandins (PG), proinflammatory factors (IL, TNF-α), and intestinal flora. Conclusion. The method of building an animal model of UC is well-established, providing a more targeted selection of animal models for future related experiments.

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Section: Resultsmentioning

confidence: 99%

Animal Models and Pathogenesis of Ulcerative Colitis

Gao

Pang

et al. 2022

Computational and Mathematical Methods in Medicine

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“…The risk of inflammatory bowel disease (IBD) is more common in countries located at a higher latitude with reduced exposure to sunlight, similar to T1D and MS [ 227 , 255 ]. IBD presents a defective innate and adaptive immunity, with increased intestinal permeability, and imbalanced gut microbiota, resulting in chronic inflammation of the intestine [ 256 , 257 , 258 ].…”

Section: Vitamin D and Immune-related And Autoimmune Diseasesmentioning

confidence: 99%

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

Simu

Rednic

Grama

et al. 2022

IJMS

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Vitamin D intervenes in calcium and phosphate metabolism and bone homeostasis. Experimental studies have shown that 1,25-dihydroxyvitamin D (calcitriol) generates immunologic activities on the innate and adaptive immune system and endothelial membrane stability. Low levels of serum 25-hydroxyvitamin D (25(OH)D) are associated with an increased risk of developing immune-related diseases such as psoriasis, type 1 diabetes, multiple sclerosis, and autoimmune diseases. Various clinical trials describe the efficacy of supplementation of vitamin D and its metabolites for treating these diseases that result in variable outcomes. Different disease outcomes are observed in treatment with vitamin D as high inter-individual difference is present with complex gene expression in human peripheral blood mononuclear cells. However, it is still not fully known what level of serum 25(OH)D is needed. The current recommendation is to increase vitamin D intake and have enough sunlight exposure to have serum 25(OH)D at a level of 30 ng/mL (75 nmol/L) and better at 40–60 ng/mL (100–150 nmol/L) to obtain the optimal health benefits of vitamin D.

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“…This suggests that VD deficit may significantly influence IBD development and course, although it is not definitively clarified whether deficiency is the cause of IBDs or malabsorption following IBD development is associated with VD deficiency, and this influences IBD course [ 94 ]. VD deficiency can be detected in about 45–50% of UC patients, whereas it ranges from 35–100% in the case of CrD, and several studies have shown a potential relationship between VD serum levels and disease activity in IBDs [ 95 ]. Ham et al studied this problem in 711 CrD patients and 764 UC patients [ 90 ].…”

Section: Vitamin D and Inflammatory Bowel Diseasementioning

confidence: 99%

Role of Vitamin D in Celiac Disease and Inflammatory Bowel Diseases

et al. 2022

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Vitamin D (VD) is a pro-hormone that has long been known as a key regulator of calcium homeostasis and bone health in both children and adults. In recent years, studies have shown that VD may exert many extra-skeletal functions, mainly through a relevant modulation of the innate and adaptive immune system. This has suggested that VD could play a fundamental role in conditioning development, clinical course, and treatment of several autoimmune disorders, including celiac disease (CD) and inflammatory bowel diseases (IBDs). The main aim of this review is to evaluate the relationships between VD, CD, and IBDs. Literature analysis showed a potential impact of VD on CD and IBDs can be reasonably assumed based on the well-documented in vitro and in vivo VD activities on the gastrointestinal tract and the immune system. The evidence that VD can preserve intestinal mucosa from chemical and immunological damage and that VD modulation of the immune system functions can contrast the mechanisms that lead to the intestinal modifications characteristic of gastrointestinal autoimmune diseases has suggested that VD could play a role in controlling both the development and the course of CD and IBDs. Administration of VD in already diagnosed CD and IBD cases has not always significantly modified disease course. However, despite these relevant problems, most of the experts recommend monitoring of VD levels in patients with CD and IBDs and administration of supplements in patients with hypovitaminosis.

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The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Cited by 29 publications

References 171 publications

Animal Models and Pathogenesis of Ulcerative Colitis

Animal Models and Pathogenesis of Ulcerative Colitis

An Update on the Effects of Vitamin D on the Immune System and Autoimmune Diseases

Role of Vitamin D in Celiac Disease and Inflammatory Bowel Diseases

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