Vitamin D and Nerve Conduction In Pediatric Type-1 Diabetes Mellitus

Polat, İpek; Yılmaz, Gülay Can; Dedeoğlu, Özge

doi:10.1016/j.braindev.2022.01.001

Cited by 7 publications

(4 citation statements)

References 31 publications

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“…The main characteristics of the 45 included studies are shown in Table 1. In accordance with the recommended NOS and AHRQ criteria, only studies of acceptable quality were included in the present meta-analysis; eight studies received 9 stars [51,53,[56][57][58]62,63,66], ten studies received 8 stars [43,[48][49][50]52,54,55,[59][60][61], ve studies received 7 stars [42,[44][45][46][47] and one study received 6 stars [41]. When using the quality assessment criteria from the AHRQ, three studies received a score of 11 [24,29,65], ten received a score of 10 [22,25,28,29,31,33,34,36,39,40], three received a score of 9 [23,32,35], one received a score of 8 [27], one received a score of 7 [37] and two received a score of 5 [26,38], the quality assessment are shown in Appendix S2.…”

Section: Resultsmentioning

confidence: 99%

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

Yang

Chai

Meng

2023

Preprint

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Background: The impact of vitamin D on type 1 diabetes has been a controversial topic in public health. Furthermore, significant differences in the proportion of vitamin D have been noted. The purpose of this systematic review was to determine the overall proportion of vitamin D deficiency in children/adolescents with type 1 diabetes (T1D). Methods: Based on six electronic databases (PubMed, Web of Science, Embase, Ovid Medline, ProQuest, and Cochrane Library), eligible studies since the databases’ inception up to April 2022 were searched. Reference lists were also manually searched to identify additional studies. Overall, studies with statistical information on vitamin D deficiency in children and adolescents with T1D were included, and a random effects model was applied for the meta-analysis. In addition, subgroup and sensitivity analyses were carried out to evaluate heterogeneity, and publication bias was evaluated by using Egger’s test. Results: A total of 45 studies involving 6,995 participants were selected for the meta-analysis. The proportion of vitamin D deficiency in children/adolescents with T1D was found to be 45% (95% confidence interval [CI] 37-54%, I2 = 97.94%). Subgroup analysis further showed that the publication year, study design, classification of vitamin D, different seasons and geographical region could significantly contribute to variations in the reported proportion of vitamin D deficiency. Conclusions: This systematic review analyzed the available literature and revealed that the proportion of vitamin D deficiency among T1D children/adolescents was 45%. In addition, the proportion remains higher, which has important implications for adapting health and social care systems.

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Section: Resultsmentioning

confidence: 99%

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

Yang

Chai

Meng

2023

Preprint

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“…Under ambient temperature of 25°C and a skin surface temperature of 31°C to 33°C, the motor conduction function of the ulnar nerve, median nerve, axillary nerve, peroneal nerve, tibial nerve, and femoral nerve was assessed using the HaiShen NDI-096 electromyography apparatus 9 , 21 . Surface electrodes were used for recording.…”

Section: Methodsmentioning

confidence: 99%

Neurophysiological Characteristics in Type II and Type III 5q Spinal Muscular Atrophy Patients: Impact of Nusinersen Treatment

Li,

Sun,

Xiang

et al. 2024

DDDT

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Objective This study aimed to observe the neurophysiological characteristics of type II and type III 5q spinal muscular atrophy (SMA) patients and the changes in peripheral motor nerve electrophysiology after Nusinersen treatment, as well as the influencing factors. Methods This single-center retrospective case–control study collected clinical data and peripheral motor nerve CMAP parameters from 42 5qSMA patients and 42 healthy controls at the Second Affiliated Hospital of Xi’an Jiaotong University (January 2021 to December 2022). It evaluated changes in motor function and CMAP amplitude before and after Nusinersen treatment. Results Our investigation encompassed all symptomatic and genetically confirmed SMA patients, consisting of 32 type II and 10 type III cases, with a median age of 57 months (29.5 to 96 months). Comparative analysis with healthy controls revealed substantial reductions in CMAP amplitudes across various nerves in both type II and type III patients. Despite the administration of Nusinersen treatment for 6 or 14 months to the entire cohort, discernible alterations in motor nerve amplitudes were not observed, except for a significant improvement in younger patients (≤36 months) at the 14-month mark. Further scrutiny within the type II subgroup unveiled that individuals with a disease duration ≤12 months experienced a noteworthy upswing in femoral nerve amplitude, a statistically significant difference when compared to those with >12 months of disease duration. Conclusion Motor nerve amplitudes were significantly decreased in type II and type III 5q SMA patients compared to healthy controls. Nusinersen treatment showed better improvement in motor nerve amplitudes in younger age groups and those with shorter disease duration, indicating a treatment-time dependence.

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“…However, more research is needed to determine the exact course of treatment and dosage. In a study of diabetes mellitus in children ( 38 ), children with vitamin D deficiency did not complain of peripheral neuropathy, but sensory nerve action potential of sural nerve and motor peroneal nerve velocity were statistically significantly lower in diabetic patients with vitamin D deficiency compared to diabetic patients with normal vitamin D levels.…”

Section: Relationship Between Vitamin D Levels and Diabetesmentioning

confidence: 95%

The impact of vitamin D on the etiopathogenesis and the progression of type 1 and type 2 diabetes in children and adults

Li,

Fu,

et al. 2024

Front. Endocrinol.

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Diabetes is a common chronic metabolic disease with complex causes and pathogenesis. As an immunomodulator, vitamin D has recently become a research hotspot in the occurrence and development of diabetes and its complications. Many studies have shown that vitamin D can reduce the occurrence of diabetes and delay the progression of diabetes complications, and vitamin D can reduce oxidative stress, inhibit iron apoptosis, promote Ca2+ influx, promote insulin secretion, and reduce insulin resistance. Therefore, the prevention and correction of vitamin D deficiency is very necessary for diabetic patients, but further research is needed to confirm what serum levels of vitamin D3 are maintained in the body. This article provides a brief review of the relationship between vitamin D and diabetes, including its acute and chronic complications.

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Vitamin D and Nerve Conduction In Pediatric Type-1 Diabetes Mellitus

Cited by 7 publications

References 31 publications

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

Proportion of vitamin D deficiency in children/adolescents with type 1 diabetes: A systematic review and meta-analysis

Neurophysiological Characteristics in Type II and Type III 5q Spinal Muscular Atrophy Patients: Impact of Nusinersen Treatment

The impact of vitamin D on the etiopathogenesis and the progression of type 1 and type 2 diabetes in children and adults

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