Vitamin D and Muscle Function

Pfeifer, Michael; Begerow, Bettina; Minne, H. W.

doi:10.1007/s001980200012

Cited by 447 publications

(308 citation statements)

References 70 publications

(94 reference statements)

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“…63,64 The vitamin D receptor and intracellular vitamin D regulation have also been identified in heart muscle, liver, lung and adrenal systems, all of which are determinants of athletic performance. 13,65,66 However, the direct evidence for treatment of vitamin D deficiency to improve performance is extremely weak. Highquality trials in athletic populations are required to determine the effects of correcting vitamin D deficiency and insufficiency on athletic, and particularly muscular, performance.…”

Section: Discussionmentioning

confidence: 99%

Low 25(OH) vitamin D concentrations in international UK track and field athletes

Pollock¹,

Dijkstra²,

Chakraverty³

et al. 2012

S. Afr. j. sports med.

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Section: Discussionmentioning

confidence: 99%

Low 25(OH) vitamin D concentrations in international UK track and field athletes

Pollock¹,

Dijkstra²,

Chakraverty³

et al. 2012

S. Afr. j. sports med.

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“…A deficiência de vitamina D está associada a uma menor mineralização do tecido osteóide caracterizando a osteomalácia (8,11). Entretanto, análises mais recentes demonstram que valores não tão reduzidos de vitamina D estão associados a aumento do turnover ósseo e conseqüente aumento de fraturas.…”

Section: Discussionunclassified

“…A população geriátrica é mais sensível à hipovitaminose D por vários motivos, dentre eles por se expor menos ao sol, ter sua capacidade de produção cutânea de vitamina D reduzida (6)(7)(8), alimentar-se de forma inadequada (9)(10)(11)(12), absorver menos vitamina D pelo trato gastrintestinal (3), usar múltiplas drogas que interferem na absorção/metabolização da vitamina D e apresentar comprometimento renal (3). Dentro deste grupo, pacientes institucionalizados têm um risco ainda maior para esta situação (13), que se reflete em um aumento de até 10,5 vezes no risco de fratura (14).…”

Section: Introductionunclassified

Prevalência da deficiência, insuficiência de vitamina D e hiperparatiroidismo secundário em idosos institucionalizados e moradores na comunidade da cidade de São Paulo, Brasil

Saraiva

Cendoroglo

Ramos

et al. 2007

Arq Bras Endocrinol Metab

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A ocorrência de fraturas osteoporóticas em idosos está relacionada às concentrações reduzidas de vitamina D e conseqüente hiperparatiroidismo secundário, sendo os institucionalizados de maior risco. No Brasil, por seu alto grau de insolação, infere-se que a quantidade de vitamina D da população seja adequada. Neste estudo, objetivamos avaliar as concentrações plasmáticas de 25-hidroxivitamina D (25OHD), paratormônio (PTH) e cálcio ionizado (Cai), assim como analisar a prevalência de hipovitaminose D e de hiperparatiroidismo secundário em idosos moradores da cidade de São Paulo. Estudamos 177 pacientes institucionalizados (125 mulheres e 52 homens) com idade média (DP) de 76,6 (9,0) anos, e 243 idosos ambulatoriais (168 mulheres e 75 homens) com 79,1 (5,9) anos. Nesta avaliação, 71,2% do grupo institucionalizado e 43,8% do ambulatorial possuíam valores de 25OHD menores do que o mínimo recomendado (50 nmol/l), sendo que as mulheres apresentaram valores consideravelmente mais baixos que os homens. O hiperparatiroidismo secundário ocorreu em 61,7% dos pacientes institucionalizados e em 54% dos ambulatoriais. Considerando os resultados obtidos, recomendamos a suplementação com doses eficientes de vitamina D para a população idosa brasileira, alem de sugerir uma discussão para a implementação de políticas de fortificação alimentar com vitamina D, especialmente direcionada àqueles com maior risco. The occurrence of osteoporotic fractures in the elderly is associated with reduced levels of vitamin D and resulting secondary hyperparathyroidism, and inpatients are the ones at a higher risk. In Brazil, given its high level of insolation, the population's large amount of vitamin D is inferred to be adequate. In this study we aimed to assess the serum levels of 25-hydroxivitamin D (25OHD), parathormone (PTH) and ionized calcium (Cai), as well as to analyze the prevalence of both hypovitaminosis D and secondary hyperparathyroidism in the elderly living in the city of São Paulo. We studied 177 inpatients (125 women and 52 men) with mean age (SD) 76.6 (9.0) years, and 243 outpatients (168 women and 75 men) aged 79.1 (5.9) years. In this assessment 71.2% in the inpatients group and 43.8% in the outpatients group had 25OHD levels below the minimum recommended (50 nmol/l), with the women presenting with levels considerably lower than the men. Secondary hyperparathyroidism occurred in 61.7% of the inpatients and in 54% of the outpatients. Considering the results achieved, we recommend vitamin D supplementation in effective doses for the Brazilian elderly population, in addition to suggesting a discussion for the implementation of vitamin D-enhanced food policies, particularly oriented to the ones at a greater risk.

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“…Some studies have suggested that one important effect of vitamin D is that it improves muscular function, which in turn would contribute to reducing falls (Pfeifer et al, 2002;Bischoff et al, 2003). The mechanisms most frequently associated with vitamin D effects are an increase in intestinal calcium absorption, a decrease in PTH secretion, and a diminution in the rate of bone remodeling (Chapuy et al, 1992;DawsonHughes et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D2 dose required to rapidly increase 25OHD levels in osteoporotic women

et al. 2006

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Objective: Assessment of the effectiveness and safety of high daily 125 mg (5000 IU) or 250 mg (10 000IU) doses of vitamin D 2 during 3 months, in rapidly obtaining adequate 25 hydroxyvitamin D (25OHD) levels. Design: Longitudinal study. Subjects: Postmenopausal osteopenic/osteoporotic women (n ¼ 38) were studied during winter and spring. Median age (25-75th percentile) was 61.5 (57.00-66.25) years, and mean bone mineral density (BMD) was 0.902 (0.800-1.042)g/cm 2 . Subjects were randomly divided into three groups: control group (n ¼ 13): no vitamin D 2 , 125 mg/day (n ¼ 13) and 250 mg/day (n ¼ 12) of vitamin D 2 groups, all receiving 500 mg calcium/day. Serum calcium, phosphate, bone alkaline phosphatase (BAP), C-telopeptide (CTX), 25OHD, mid-molecule parathyroid hormone (mmPTH), daily urinary calcium and creatinine excretion were determined at baseline and monthly. Results: For all subjects (n ¼ 38), the median baseline 25 hydroxyvitamin D (25OHD) level was 36.25 (27.5-48.12) nmol/l. After 3 months, 8% of the patients in the control group, 50% in the 125 mg/day group and 75% in the 250 mg/day group had 25OHD values above 85 nmol/l (34 ng/ml). Considering both vitamin D 2 groups together, mmPTH and BAP levels diminished significantly after 3 months (Po0.02), unlike those of CTX. Serum calcium remained within normal range during the follow-up. Conclusions: The oral dose of vitamin D 2 required to rapidly achieve adequate levels of 25OHD is seemingly much higher than the usual recommended vitamin D 3 dose (20 mg/day). During 3 months, 250 mg/day of vitamin D 2 most effectively raised 25OHD levels to 85 nmol/l in 75% of the postmenopausal osteopenic/osteoporotic women treated.

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Vitamin D and Muscle Function

Cited by 447 publications

References 70 publications

Low 25(OH) vitamin D concentrations in international UK track and field athletes

Low 25(OH) vitamin D concentrations in international UK track and field athletes

Prevalência da deficiência, insuficiência de vitamina D e hiperparatiroidismo secundário em idosos institucionalizados e moradores na comunidade da cidade de São Paulo, Brasil

Vitamin D2 dose required to rapidly increase 25OHD levels in osteoporotic women

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