Vitamin D and Hypertension

Jeong, Hye Yun; Park, Kyung Mi; Lee, Mi Jung; Yang, Dong Ho; Kim, Sang Hoon; Lee, So‐Young

doi:10.5049/ebp.2017.15.1.1

Cited by 44 publications

(36 citation statements)

References 95 publications

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“… 15 , 25 The possible association between vitamin D levels and many ischemic risk factors can strengthen such a notion. 3 , 6 – 8 , 25 , 26 However, similar to other studies, 15 , 22 , 27 results of the current study did not show significant association between these abnormalities and the incidence or prevalence of IHD.…”

Section: Discussionsupporting

confidence: 85%

“…Factors related to the metabolic syndrome, 6 such as hypertension, 8 , 9 DM 7 , 26 and dyslipidemia, have been associated with vitamin D abnormalities. In Jordan, previous studies did not show clear associations between vitamin D levels and these factors.…”

Section: Discussionmentioning

confidence: 99%

“… 7 As well, recent meta-analysis reviews suggested an indirect role of vitamin D in controlling blood pressure. 8 , 9 Moreover, many studies suggested an integral role for the active form of vitamin D (calcitriol) in modulating inflammatory response. However, the clinical value of vitamin D in modulating inflammatory diseases is still controversial.…”

Section: Introductionmentioning

confidence: 99%

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The association between the serum level of vitamin D and ischemic heart disease: a study from Jordan

Jarrah¹,

Mhaidat²,

Alzoubi³

et al. 2018

VHRM

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BackgroundDecreased levels of vitamin D were associated with increased risk of multiple diseases, including cardiovascular diseases. However, there seem to be some discrepancies among the results obtained from different studies. The aim of the present study was to explore the importance of having sufficient serum levels of vitamin D in reducing the incidence and the progression of coronary artery stenosis and ischemic heart disease (IHD).MethodsSerum levels of vitamin D were measured using radioimmunoassay in 186 Jordanian patients who underwent investigative coronary catheterization. Of these patients, 133 were suffering from coronary artery stenosis. The association between vitamin D levels, coronary stenosis and many risk factors was determined using SPSS software.Results and conclusionsInterestingly, the current results did not show an association between vitamin D abnormalities and the incidence or the reoccurrence of coronary artery stenosis. Moreover, significant differences were detected in the prevalence of vitamin D abnormalities based on the patient’s gender, and there was a significant association between vitamin D abnormalities and both body mass index and dyslipidemia. However, current results did not show any significant association with other risk factors for IHD. For instance, no association was found with smoking, hypertension, diabetes mellitus, stable and unstable angina or with acute recent myocardial infarction.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The association between the serum level of vitamin D and ischemic heart disease: a study from Jordan

Jarrah¹,

Mhaidat²,

Alzoubi³

et al. 2018

VHRM

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“…Among adults, a wealth of observational data has demonstrated a relationship between low serum levels of 25OHD and hypertension [12][13][14], although no evidence of a clinically significant reduction in BP as a result of vitamin D supplementation has been observed [14].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Supplementation and Blood Pressure in Children and Adolescents: A Systematic Review and Meta-Analysis

Abboud

2020

Nutrients

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Suboptimal vitamin D status is associated with elevated blood pressure (BP) in children and adolescents. Whether vitamin D supplementation reduces BP remains unclear. To systematically review whether vitamin D supplementation reduces BP in children and adolescents, we conducted a literature review according to the PRISMA statement. We included vitamin-D supplementation human interventions studies that reported on BP as an outcome. We searched PUBMED, MEDLINE, CINAHL, EMBASE, the Cochrane Library, and the clinical trials website. We also hand searched the references of the included articles and previous reviews of vitamin D therapy. No language or time restrictions were applied. We extracted data on population characteristics, baseline and endline vitamin D and BP values, and assessed the risk of bias of the included studies. We performed a narrative review of the findings, conducted a meta-analysis when possible, and performed sensitivity analyses to test the robustness of our results. We assessed the overall quality of the evidence produced in the meta-analysis. We included eight studies in our review and five studies in the meta-analysis, none of which included hypertensive only participants. The risk of bias was variable. In non-randomized studies, no effect of vitamin D supplementation was seen on systolic BP (SBP) (mean difference: 0.39 (95% confidence interval (CI): −0.9; 1.68) mmHg; p = 0.55; I2 = 0%). Only a significant decrease in diastolic BP (DBP) (mean difference: −1.87 (95% CI: −3.02; −0.72) mmHg; p = 0.001; I2 = 0%) was noted. Both analyses had a low quality of evidence. In randomized controlled trials (RCTs), no effect was noted on SBP (mean difference: −2.04 (95% CI: −5.12; 1.04) mmHg; p = 0.19; I2 = 71%) nor DBP (mean difference: 0.01 (95% CI: −1.09; 1.12) mmHg; p = 0.98; I2 = 0%). The final quality of evidence ranged between low and moderate. Sensitivity analyses did not affect the results. Vitamin D supplementation was found to be ineffective in lowering SBP and DBP in children and adolescents.

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“…This kind of calcium depletion is the starting point for bone-related complaints. It has the capacity to act against cancer as well as decrease blood pressure and increase insulin secretion [26][27][28]. For these reasons, Vitamin D3 demand is still increasing.…”

Section: Gc-ms Analysismentioning

confidence: 99%

Identification of Bioactive Compounds in Flower of Tabernaemontana Divaricata (L.) Using Gas Chromatography–mass Spectrometry Analysis

Kalaimagal¹

2019

Asian J Pharm Clin Res

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Objective: Herbs are a key resource with therapeutic properties. Nowadays, there is a focus on the identification of bioactive compounds with the ability to act against various disorders. Methods: In the present study, gas chromatography–mass spectrometry analysis was conducted to determine the occurrence of different phytochemical compounds in ethanolic flower extract of Tabernaemontana divaricata (L.). Results: The ethanol extract of flower revealed the presence of several bioactive compounds such as n-hexadecanoic acid, squalene, Vitamin D3, Vitamin A aldehyde, desulfosinigrin, and Urs-12-en-24-oic acid, 3-oxo-, methyl ester, (+)-. Conclusion: The perceived compounds from ethanolic extract of flower have diverse beneficial properties such as antimicrobial, antioxidant, cancer anticipatory effect, pesticide, and antiarthritic.

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Vitamin D and Hypertension

Cited by 44 publications

References 95 publications

The association between the serum level of vitamin D and ischemic heart disease: a study from Jordan

The association between the serum level of vitamin D and ischemic heart disease: a study from Jordan

Vitamin D Supplementation and Blood Pressure in Children and Adolescents: A Systematic Review and Meta-Analysis

Identification of Bioactive Compounds in Flower of Tabernaemontana Divaricata (L.) Using Gas Chromatography–mass Spectrometry Analysis

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