Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats

Zhang, Xiaolei; Shang, Xueying; Jin, Shi; Ma, Zhuoqi; Wang, He; Ao, Na; Yang, Jing; Du, Juan

doi:10.1016/j.abb.2021.108894

Cited by 36 publications

(27 citation statements)

References 41 publications

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“…Zhang et al demonstrated that vitamin D can attenuate HFD-induced liver injury by inhibiting pyroptosis and altering gut microbiota in a rat model. Furthermore, vitamin D attenuates HFD-induced hepatic injury in vivo and impairment of liver cell viability in vitro , as well as inhibiting lipid accumulation, NLRP3 inflammasome activation, and pyroptosis in vitro and in vivo ( Zhang et al, 2021 ); however, findings regarding the potential benefits of vitamin D for patients with NAFLD in several clinical trials have been inconsistent. The differences among studies may be attributable to variation in the degree of patient liver injuries, comorbidities, and concomitant medications.…”

Section: Pharmacological Agents Associated With Nlrp3 Inflammasome Su...mentioning

confidence: 99%

The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment

Wang

et al. 2022

Front. Pharmacol.

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Non-alcoholic fatty liver disease (NAFLD) is among the most prevalent primary liver diseases worldwide and can develop into various conditions, ranging from simple steatosis, through non-alcoholic steatohepatitis (NASH), to fibrosis, and eventually cirrhosis and hepatocellular carcinoma. Nevertheless, there is no effective treatment for NAFLD due to the complicated etiology. Recently, activation of the NLPR3 inflammasome has been demonstrated to be a contributing factor in the development of NAFLD, particularly as a modulator of progression from initial hepatic steatosis to NASH. NLRP3 inflammasome, as a caspase-1 activation platform, is critical for processing key pro-inflammatory cytokines and pyroptosis. Various stimuli involved in NAFLD can activate the NLRP3 inflammasome, depending on the diverse cellular stresses that they cause. NLRP3 inflammasome-related inhibitors and agents for NAFLD treatment have been tested and demonstrated positive effects in experimental models. Meanwhile, some drugs have been applied in clinical studies, supporting this therapeutic approach. In this review, we discuss the activation, biological functions, and treatment targeting the NLRP3 inflammasome in the context of NAFLD progression. Specifically, we focus on the different types of therapeutic agents that can inhibit the NLRP3 inflammasome and summarize their pharmacological effectiveness for NAFLD treatment.

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Section: Pharmacological Agents Associated With Nlrp3 Inflammasome Su...mentioning

confidence: 99%

The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment

Wang

et al. 2022

Front. Pharmacol.

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“…For cells expressing a low level of GSDME, the active caspase-3 will induce apoptosis [ 29 , 34 , 35 ]. In recent years, pyroptosis has been reported to play a vital role in many diseases, including liver diseases [ 36 , 37 ]. However, the related mechanism is not completely clear.…”

Section: Overview Of Pyroptosismentioning

confidence: 99%

The Role of Autophagy and Pyroptosis in Liver Disorders

Zhao

Liu

Yang

et al. 2022

IJMS

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Pyroptosis is a programmed cell death caused by inflammasomes, which can detect cell cytosolic contamination or disturbance. In pyroptosis, caspase-1 or caspase-11/4/5 is activated, cleaving gasdermin D to separate its N-terminal pore-forming domain (PFD). The oligomerization of PFD forms macropores in the membrane, resulting in swelling and membrane rupture. According to the different mechanisms, pyroptosis can be divided into three types: canonical pathway-mediated pyroptosis, non-canonical pathway-mediated pyroptosis, and caspase-3-induced pyroptosis. Pyroptosis has been reported to play an important role in many tissues and organs, including the liver. Autophagy is a highly conserved process of the eukaryotic cell cycle. It plays an important role in cell survival and maintenance by degrading organelles, proteins and macromolecules in the cytoplasm. Therefore, the dysfunction of this process is involved in a variety of pathological processes. In recent years, autophagy and pyroptosis and their interactions have been proven to play an important role in various physiological and pathological processes, and have gradually attracted more and more attention to become a research hotspot. Therefore, this review summarized the role of autophagy and pyroptosis in liver disorders, and analyzed the related mechanism to provide a basis for future research.

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“…VDR is highly expressed in normal gut epithelial cells, especially in the crypts. The VitD/VDR signaling pathway plays a major role in maintaining gut homeostasis through the regulation of tight junctions and adherent junction components, as well as the release of antimicrobial peptides, such as defensins [ 194 , 195 , 196 ].…”

Section: Vitamin D and Human Microbiotamentioning

confidence: 99%

“…The gut-microbiota–Vit-D axis also works the other way around: it has been reported that intact Vit D signaling is important for a healthy gut microbiome: mice with disrupted Vit D metabolism had intestinal dysbiosis [ 190 ], while adults with cystic fibrosis supplemented with Vit D modified their gut and airway microbiota, with an enrichment of Lactococcus , which is associated with improved gut health [ 205 ]. Vit D also restored high-fat-diet-induced gut microbiota dysbiosis by increasing the relative abundance of Lactobacillii and attenuated high-fat-diet-induced hepatic injury in vivo [ 195 ]. By contrast, high doses of Vit D given to healthy adults did not change the composition of the stool microbiome [ 206 ].…”

Section: Vitamin D and Human Microbiotamentioning

confidence: 99%

The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

et al. 2022

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Background: Vitamin D exerts multiple beneficial effects in humans, including neuronal, immune, and bone homeostasis and the regulation of cardiovascular functions. Recent studies correlate vitamin D with cancer cell growth and survival, but meta-analyses on this topic are often not consistent. Methods: A systematic search of the PubMed database and the Clinical Trial Register was performed to identify all potentially relevant English-language scientific papers containing original research articles on the effects of vitamin D on human health. Results: In this review, we analyzed the antioxidant and anti-inflammatory effects of vitamin D against acute and chronic diseases, focusing particularly on cancer, immune-related diseases, cardiomyophaties (including heart failure, cardiac arrhythmias, and atherosclerosis) and infectious diseases. Conclusions: Vitamin D significantly reduces the pro-oxidant systemic and tissue biomarkers involved in the development, progression, and recurrence of chronic cardiometabolic disease and cancer. The overall picture of this review provides the basis for new randomized controlled trials of oral vitamin D supplementation in patients with cancer and infectious, neurodegenerative, and cardiovascular diseases aimed at reducing risk factors for disease recurrence and improving quality of life.

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Vitamin D ameliorates high-fat-diet-induced hepatic injury via inhibiting pyroptosis and alters gut microbiota in rats

Cited by 36 publications

References 41 publications

The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment

The NLRP3 Inflammasome in Non-Alcoholic Fatty Liver Disease and Steatohepatitis: Therapeutic Targets and Treatment

The Role of Autophagy and Pyroptosis in Liver Disorders

The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

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