The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

Berretta, Massimiliano; Quagliariello, Vincenzo; Bignucolo, Alessia; Facchini, Sergio; Maurea, Nicola; Francia, Raffaele Di; Fiorica, Francesco; Sharifi, Saman; Bressan, Silvia; Richter, Sara N.; Camozzi, Valentina; Rinaldi, Luca; Scaroni, Carla; Montopoli, Monica

doi:10.3390/antiox11061090

Cited by 18 publications

(17 citation statements)

References 219 publications

(255 reference statements)

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“…Small-fiber degeneration and nociceptor sensitization are the main observed mechanisms ( 36 ). Vitamin D insufficiency or disorders of iron metabolism may have a negative impact on both innate and adaptive immunity and the development and function of the nervous system ( 35 , 37 – 39 ). Long-term exposure to tobacco increases pain sensitivity due to nicotinic acetylcholine receptor desensitization and neuronal plastic changes ( 40 ).…”

Section: Discussionmentioning

confidence: 99%

Observational case-control study of small-fiber neuropathies, with regards on smoking and vitamin D deficiency and other possible causes

et al. 2023

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IntroductionSmall fiber neuropathies (SFNs) are disorders of skin nerve endings inducing pruritus, burning pain, numbness, and paresthesia. The aims of this study were to search for putative etiologies of SFN and their occurrence in a cohort of patients and to compare patients with SFN to a group of patients without SFN to highlight potential factors associated with SFN.MethodsThis study was observational, retrospective, and monocentric. All patients with symptoms of SFN who underwent skin biopsies with intraepidermal nerve density counts were included. Patients with a count lower than 5 percentiles were considered to be in the SFN group. Other patients were considered to be the control group.ResultsA total of 162 patients with SFN and 161 controls were included. No cause was identified for 108 patients (61.7%). The established causes were autoimmune diseases (9.1%), diabetes or glucose intolerance (8%), medication (4%), liver disease (3.4%), and monoclonal gammopathy of undetermined significance (2.9%). Current or former smokers were more numerous in the SFN group (26.5%) than in the control group (16.1%), while vitamin D amounts were significantly lower in the SFN group than in the control group.DiscussionHence, tobacco smoking and vitamin D deficiency might be new putative causes of SFN.

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Section: Discussionmentioning

confidence: 99%

Observational case-control study of small-fiber neuropathies, with regards on smoking and vitamin D deficiency and other possible causes

et al. 2023

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“…In vitamin D-enriched adults, vitamin D supplementation alone did not provide health bene ts, but vitamin D de ciency should permanently be corrected [46]. Another recent review showed that the level of biomarkers related to chronic heart metabolic diseases and cancer is signi cantly reduced by vitamin D [47]. In a survey of different countries, different diseases, and different supplements, it was found that current research disagrees the recommendation of sh oil and vitamin supplementation to weaken the risk of disease in people without nutritional de ciencies [48] and that excessive vitamin D activity can also induce vascular calci cation [49].…”

Section: Discussionmentioning

confidence: 99%

Association Between Serum 25(OH)D and Risk of All-Cause Mortality in Adults with Prior Cardiovascular Disease: A Cohort Study From NHANES 2007-2018

Chen

Shi

et al. 2022

Preprint

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Background Serum vitamin D deficiency is common in the patients with cardiovascular disease (CVD), but the association between serum vitamin D levels and risk of all-cause mortality in patients with CVD is controversial. Objective This study aimed to understand better the association between serum 25(OH)D status and risk of all-cause mortality in patients with prior CVD. Method We conducted a cohort study using data from the National Health and Nutrition Examination Survey from 2007–2018 to investigate the association between serum 25(OH)D and the risk of all-cause mortality using multivariate Cox regression models, with further subgroup analyses and interactions smooth curve fitting to address possible nonlinearities. Result A total of 3220 participants with prior CVD were included in this study, with a total of 930 deaths over a median follow-up of 5.52 years, with multivariable-adjusted serum vitamin D levels (< 25 nmol/L) as a reference in COX regression, and corrected HRs and 95% CIs of 1.00 (reference), 0.74 (0.55, 1.00), 0.69 (0.51, 0.93), and 0.58 (0.43, 0.79) for all-cause mortality, respectively. Results remained robust in the stratified analysis of interactions, but a U-shaped relationship was detected. We identified an inflection point of 89.8 nmol/L after multivariate adjustment through a two-stage linear regression model and recursive algorithm. Conclusion Our findings demonstrate that increasing serum 25(OH)D levels may have a U-shaped relationship with risk of all-cause mortality and that increases in serum 25(OH)D levels do not continue to reduce the risk of all-cause mortality beyond specific criteria have a diminished protective effect.

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“…It is also suggested that Vit D has antioxidant properties due to its effects such as inducing the expression of various molecules in the antioxidant defense system such as GSH, GSH peroxidase, and SOD, and suppressing the expression of NADPH oxidase. However, there are few studies on its antioxidant properties, and it is not clear whether it is actually an antioxidant or pro-oxidant [14,15] Vitamin D3 (cholecalciferol) is formed by the interaction of 7-Dehydrocholesterol in the skin with sunlight. Cholecalciferol (Vitamin D3) and oral vitamin D are metabolized in the liver to 25-hydroxycholecalciferol (Calcifediol; 25(OH)D3), and this compound is then hydroxylated at the 1α-position in the kidney to convert it into the active form, 1,25-Dihydroxycholecalciferol (Calcitriol; 1,25(OH) 2 D3).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Effect of Calcitriol on Radiofrequency Radiation Exposed Breast Cancer Cell Lines

ELÇİ,

FATSA,

ÖREN

et al. 2024

Preprint

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Radiofrequency (RF) fields have been classified as probable human carcinogens and non-thermal RF-radiation (RFR) can cause an increase in oxidative stress and inflammation in tissues. Vitamin D has been researched for many years for its anti-cancer and suppressive effects on cancer cell growth. In this study, we aimed to examine the effects of exposure to RF signals on cell viability, free radical formation, and related inflammation, and the restorative effect of vitamin D against this. For this purpose, MCF-7 and MDA-MB-231 cells were exposed to 2.1GHz W-CDMA-modulated RFR. The viability of cells was determined by MTT assay, and the percentage of apoptotic cells was determined by FITC-conjugated Annexin-V/PI assay. The expression levels of VDR, NF- κB, COX-2, and p53 genes were studied using Real-Time-PCR. ROS analysis was performed by flow cytometry. A statistically significant decrease in MCF-7 cell viability (p < 0.001) was observed with increasing doses of calcitriol compared to the control group, while no significant difference was observed in MDA-MB-231 cells (p > 0.05). As a result of ROS analysis, significant decreases in life values were observed for both cells due to calcitriol. A statistically significant increase in p53 expression was observed with increasing calcitriol dose in both cell lines. An increase in VDR, NF-kappa B, and COX2 expressions was also observed in MCF-7 cells. We observed that calcitriol administered after RF exposure caused an increase in apoptosis and mRNA expression of inflammation markers, a decrease in ROS levels, and an increase, and this can be evaluated in cancer treatment or prevention.

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The Multiple Effects of Vitamin D against Chronic Diseases: From Reduction of Lipid Peroxidation to Updated Evidence from Clinical Studies

Cited by 18 publications

References 219 publications

Observational case-control study of small-fiber neuropathies, with regards on smoking and vitamin D deficiency and other possible causes

Observational case-control study of small-fiber neuropathies, with regards on smoking and vitamin D deficiency and other possible causes

Association Between Serum 25(OH)D and Risk of All-Cause Mortality in Adults with Prior Cardiovascular Disease: A Cohort Study From NHANES 2007-2018

Investigation of the Effect of Calcitriol on Radiofrequency Radiation Exposed Breast Cancer Cell Lines

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