2007
DOI: 10.1074/jbc.m608361200
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Vitamin C Is an Essential Antioxidant That Enhances Survival of Oxidatively Stressed Human Vascular Endothelial Cells in the Presence of a Vast Molar Excess of Glutathione

Abstract: Cellular glutathione levels may exceed vitamin C levels by 10-fold, generating the question about the real antioxidant role that low intracellular concentrations of vitamin C can play in the presence of a vast molar excess of glutathione. We characterized the metabolism of vitamin C and its relationship with glutathione in primary cultures of human endothelial cells oxidatively challenged by treatment with hydrogen peroxide or with activated cells undergoing the respiratory burst, and analyzed the manner in wh… Show more

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Cited by 82 publications
(54 citation statements)
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“…In agreement with previous studies [42], HUVECs were found to express GLUT1 and GLUT3, and moderate amounts of GLUT6, GLUT8 and GLUT 10 (>100 copies/ng mRNA) as well as small amounts of GLUT 9, 11 and 12 (<100 copies/ng mRNA) ( Figure 1A). SGLT1 or GLUT2, 4, 5, 7 and 14 were not detected (<0.8 copy/ng mRNA), indicating lack of fructose transporters and insulin-responsive transporters.…”
Section: Glut Transporter Expression In Endothelial Cellssupporting
confidence: 92%
“…In agreement with previous studies [42], HUVECs were found to express GLUT1 and GLUT3, and moderate amounts of GLUT6, GLUT8 and GLUT 10 (>100 copies/ng mRNA) as well as small amounts of GLUT 9, 11 and 12 (<100 copies/ng mRNA) ( Figure 1A). SGLT1 or GLUT2, 4, 5, 7 and 14 were not detected (<0.8 copy/ng mRNA), indicating lack of fructose transporters and insulin-responsive transporters.…”
Section: Glut Transporter Expression In Endothelial Cellssupporting
confidence: 92%
“…The average vitamin C content in 'Voghera' fruits ranged from 203 to 241 mg/100 g fw, a considerable concentration, compared to nutritional tables, which report an average reference concentration of 155 mg/100 g fw in yellow and red sweet pepper. This is four times higher than the recommended daily intake of this antioxidant compound that is so important for human health (Montecinos et al, 2007;USDA, 2011). Vitamin C content is kept by cold storage and partially preserved by traditional storage in vinegar.…”
Section: Discussionmentioning
confidence: 83%
“…26-44 . However, other studies have indicated that antioxidants may protect cells from oxidative stress and thus protect against cell death. 45,46 Whilst those studies examined the effects of antioxidants on eukaryotic cells, it is possible that antioxidants may have a similar protective effect against bacterial cell death. Interestingly, a previous study has reported only low antioxidant capacities for A. moluccanus nut essential oils.…”
Section: Discussionmentioning
confidence: 99%