Vitamin C inhibits the growth of a bacterial risk factor for gastric carcinoma: Helicobacter pylori

Zhang, Hui‐Min; Wakisaka, Noriko; Maeda, Osamu; Yamamoto, Takatsugu

doi:10.1002/(sici)1097-0142(19971115)80:10<1897::aid-cncr4>3.3.co;2-9

Cited by 54 publications

(82 citation statements)

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“…A possible relation between H. pylori infection and ascorbic acid is under investigation, as some research has indicated that high-dose vitamin C is effective in inhibiting H. pylori infection [41,42].…”

Section: Vitamin C (Ascorbic Acid)mentioning

confidence: 99%

Diet and the risk of gastric cancer: review of epidemiological evidence

Tsugane¹,

Sasazuki²

2007

Gastric Cancer

383

265

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Section: Vitamin C (Ascorbic Acid)mentioning

confidence: 99%

Diet and the risk of gastric cancer: review of epidemiological evidence

Tsugane¹,

Sasazuki²

2007

Gastric Cancer

383

265

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“…It has been reported that α-tocopherol could ameliorate the aggravation of stress-associated gastric mucosal damage (25). In in vivo assays, the consumption of vitamins C and E could reduce the gastric H. pylori loads in animal models (26)(27)(28)(29). Sies et al (30) showed that the concentrations of α-tocopherol in H. pylori-negative subjects were higher in the corpus than in the antrum or duodenum.…”

Section: Resultsmentioning

confidence: 99%

Comparison of standard and standard plus vitamin E therapy for Helicobacter pylori eradications in children

Tümgör

Baran²,

Çakır³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Although various drugs can be used in adults for Helicobacter pylori eradication in adults, treatment options are limited in children. The aim of this study was to compare the effects of the standard lansoprazole, amoxicillin, and clarithromycin (LAC) protocol to those of LAC + vitamin E (LACE) combination for H. pylori eradication. Materials and Methods: The study included 90 children (age range: 10-17 years) who were admitted to four pediatric gastroenterology centers between March 2011 and November 2012 with dyspeptic symptoms and who had tested positive for H. pylori by 14C-urea breath tests. The patients were randomized into two groups. The LAC group [45 patients (pts)] was treated with a standard regimen consisting of lansoprazole (1 mg/kg/day), amoxicillin (50 mg/kg/ day), and clarithromycin (14 mg/kg/day), each of which was given in two equally divided doses every 12 h for 14 days; the LACE group (45 pts) was given the standard regimen and vitamin E at 200 IU/day for 14 days. H. pylori eradication was assessed using the 14C-UBT in the 6th week after the cessation of treatment. Results: H. pylori was eradicated in 21 (46.6%) pts in the LAC group, while it was eradicated in 29 (64.4%) pts in the LACE group. There was no statistical difference between the two groups (p=0.13). Conclusion: The eradication rate of H. pylori in children while using the LAC regimen has decreased in the last years. The LACE regimen has been associated with an increased eradication rate but can reach to statistically significance. Further studies with larger cohorts are needed to examine the success of the LACE regimen for H. pylori eradication.

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“…In our data, we did not observe a statistically significant interaction between dietary intake of vitamin C (or plasma concentration of vitamin C) and processed meat intake. Another potential mechanism is that vitamin C may act by inhibiting or slowing the infection and growth of H. pylori in the gastric mucosa (Pal et al 2011;Zhang et al 1997). Weaknesses of our study include potential misclassification of dietary intake of foods containing vitamin C (and lack of information on use of dietary supplements) and imprecision in plasma vitamin C measurements.…”

Section: Discussionmentioning

confidence: 99%

“…infection in the gastric mucosa has been associated with pro-inflammatory responses and mucosal proliferation, as well as lower vitamin C levels in blood and gastric juice, possibly due to malabsorption or decreased stability and bioavailability (Lahner et al 2012). In addition, very high doses of vitamin C may inhibit H. pylori infection, growth, and reinfection (Pal et al 2011;Zhang et al 1997). As a consequence, the multistep process of gastric cancer carcinogenesis involving chronic H. pylori infection may be slowed or partially reversed in some individuals with high intake of vitamin C.…”

Section: Introductionmentioning

confidence: 99%

Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

et al. 2013

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Vitamin C is known to protect mucosal tissues from oxidative stress and inhibit nitrosamine formation in the stomach. High consumption of fruits, particularly citrus, and higher circulating vitamin C concentrations may be inversely associated with gastric cancer (GC) risk. We investigated 20 polymorphisms in vitamin C transporter genes SCL23A1 and SCL23A2 and GC risk in 365 cases and 1,284 controls nested within the European Prospective Investigation into Cancer and Nutrition cohort. We also evaluated the association between these polymorphisms and baseline plasma vitamin C levels in a subset of participants. Four SNPs were predictors of plasma vitamin C Electronic supplementary material The online version of this article (doi:10.1007/s12263-013-0346-6) contains supplementary material, which is available to authorized users. 123Genes Nutr (2013) 8:549-560 DOI 10.1007/s12263-013-0346-6 levels (SLC23A1 rs11950646 and rs33972313; SLC23A2 rs6053005 and rs6133175) in multivariable linear regression models. One SNP (SLC23A2 rs6116569) was associated with GC risk, in particular non-cardia GC (OR = 1.63, 95 % CI = 1.11-2.39, based on 178 noncardia cases), but this association was attenuated when plasma vitamin C was included in the logistic regression model. Haplotype analysis of SLC23A1 yielded no associations with GC. In SLC23A2, one haplotype was associated with both overall and non-cardia GC, another haplotype was associated with GC overall, and a third was associated with intestinal-type GC. Common variants in SLC23A1 and SLC23A2 may influence plasma vitamin C concentration independent of dietary intake, and variation in SLC23A2 may influence GC risk. Additional prospective studies in large populations and consortia are recommended. Investigation of variation in vitamin C transporter genes may shed light on the preventative properties of vitamin C in gastric carcinogenesis.

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Vitamin C inhibits the growth of a bacterial risk factor for gastric carcinoma: Helicobacter pylori

Abstract: High doses of vitamin C inhibit the growth of H. pylori in vitro as well as in vivo.

Cited by 54 publications

References 0 publications

Diet and the risk of gastric cancer: review of epidemiological evidence

Diet and the risk of gastric cancer: review of epidemiological evidence

Comparison of standard and standard plus vitamin E therapy for Helicobacter pylori eradications in children

Vitamin C transporter gene (SLC23A1 and SLC23A2) polymorphisms, plasma vitamin C levels, and gastric cancer risk in the EPIC cohort

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