Vitamin C and vitamin C plus E improve the immune function in the elderly

Fuente, Mónica De la; Sanchez, Carmen María; Vallejo, Carmen; Cerro, Estefanía Díaz-Del; Arnalich, Francisco; Hernánz, Ángel

doi:10.1016/j.exger.2020.111118

Cited by 40 publications

(31 citation statements)

References 65 publications

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“…On the other hand, nutrition can be a useful intervention to delay aging and treat aging-related diseases [ 125 , 126 ]. These interventions include caloric restriction [ 127 , 128 , 129 , 130 , 131 ], variations in macronutrient ratios [ 132 , 133 ], dietary supplementation with probiotics [ 134 , 135 , 136 ], vitamins [ 137 , 138 ] and antioxidants [ 139 , 140 ], among many others. Various pieces of evidence demonstrate that all these types of nutritional interventions can modulate immune function in aging [ 138 , 139 , 141 , 142 , 143 , 144 , 145 ], in addition to improving the oxidative and inflammatory state of these cells [ 136 , 138 , 139 , 144 , 146 ], thus slowing down oxi-inflamm-aging and lengthening life expectancy [ 147 , 148 , 149 ].…”

Section: Lifestyle Situations Modulating the Rate Of Aging: Friends Or Foes?mentioning

confidence: 99%

The Role of Immune Cells in Oxi-Inflamm-Aging

Toda

Ceprián

Cerro

et al. 2021

Cells

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Aging is the result of the deterioration of the homeostatic systems (nervous, endocrine, and immune systems), which preserve the organism’s health. We propose that the age-related impairment of these systems is due to the establishment of a chronic oxidative stress situation that leads to low-grade chronic inflammation throughout the immune system’s activity. It is known that the immune system weakens with age, which increases morbidity and mortality. In this context, we describe how the function of immune cells can be used as an indicator of the rate of aging of an individual. In addition to this passive role as a marker, we describe how the immune system can work as a driver of aging by amplifying the oxidative-inflammatory stress associated with aging (oxi-inflamm-aging) and inducing senescence in far tissue cells. Further supporting our theory, we discuss how certain lifestyle conditions (such as social environment, nutrition, or exercise) can have an impact on longevity by affecting the oxidative and inflammatory state of immune cells, regulating immunosenescence and its contribution to oxi-inflamm-aging.

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Section: Lifestyle Situations Modulating the Rate Of Aging: Friends Or Foes?mentioning

confidence: 99%

The Role of Immune Cells in Oxi-Inflamm-Aging

Toda

Ceprián

Cerro

et al. 2021

Cells

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“…Nutrients and bioactive substances have shed new light on the prevention and treatment of chronic diseases and aging. For example, short-term supplementation with appropriate doses of vitamin C or vitamin C plus E has already been confirmed to improve the immunological function in the elderly and contribute to health and longevity (De la Fuente et al, 2020 ). Most of the substances that exert bioactive properties originate from natural plants and animals and have been extensively studied for their preventive and therapeutic effects against chronic diseases and aging.…”

Section: Introductionmentioning

confidence: 99%

The Review of Anti-aging Mechanism of Polyphenols on Caenorhabditis elegans

Liu

Guo

Wang

et al. 2021

Front. Bioeng. Biotechnol.

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Micronutrients extracted from natural plants or made by biological synthesis are widely used in anti-aging research and applications. Among more than 30 effective anti-aging substances, employing polyphenol organic compounds for modification or delaying of the aging process attracts great interest because of their distinct contribution in the prevention of degenerative diseases, such as cardiovascular disease and cancer. There is a profound potential for polyphenol extracts in the research of aging and the related diseases of the elderly. Previous studies have mainly focused on the properties of polyphenols implicated in free radical scavenging; however, the anti-oxidant effect cannot fully elaborate its biological functions, such as neuroprotection, Aβ protein production, ion channel coupling, and signal transduction pathways. Caenorhabditis elegans (C. elegans) has been considered as an ideal model organism for exploring the mechanism of anti-aging research and is broadly utilized in screening for natural bioactive substances. In this review, we have described the molecular mechanisms and pathways responsible for the slowdown of aging processes exerted by polyphenols. We also have discussed the possible mechanisms for their anti-oxidant and anti-aging properties in C. elegans from the perspective of different classifications of the specific polyphenols, such as flavonols, anthocyanins, flavan-3-ols, hydroxybenzoic acid, hydroxycinnamic acid, and stilbenes.

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“…Vitamin C is an important antioxidant which can prevent the oxidative damage to the retina (13). A high level of vitamin C in retina alleviates free radicals and improves immune cell function generated by its high metabolic activity (9). As a result, there has been persistent interest in antioxidant approaches (such as vitamin C) to combat oxidative stress in retinal diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin C is an antioxidant for humans, with pleiotropic functions such as antioxidation and a cofactor of a large number of biosynthetic and gene regulatory enzymes. Supplementation of vitamin C also contributes to immune defense by improving the function of the human innate and adaptive immune system, such as antimicrobial and natural killer cell activities, lymphocyte proliferation (9). A cumulative number of studies on animal and human with dietary supplementation of antioxidants (including vitamin C) were found to restore glutathione level and inhibit oxidative damage in the retina (10).…”

Section: Introductionmentioning

confidence: 99%

Choroidal and Retinal Thickness in Patients with Vitamin C Deficiency

Qian

Wang

Qiang

et al. 2021

Preprint

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Purpose: to investigate the effects of vitamin C on central retinal thickness and choroidal thickness.Methods: A total of 72 patients diagnosed with vitamin C deficiency and 1:1 age- and gender-matched 72 healthy individuals with normal serum vitamin C were included in this study. Demographic characteristics of the individuals were collected. All patients underwent a comprehensive ophthalmic examination. Subfoveal choroidal thickness and retinal thickness were measured using a swept-source optical coherence tomography (SS-OCT). Results: The average retinal thickness was 268.96 ± 14.01um in the vitamin C deficiency group and 276.69 ± 13.28um in the control group. The average choroidal thickness was 195.06 ± 66.35um in the in the vitamin C deficiency group and 238.53 ± 56.20um in the control group. There was a significant decrease in both average choroidal thickness and retinal thickness in vitamin C deficiency group compared with normal individuals (p < 0.001, and = 0.003 respectively).Conclusion: The central retinal and choroidal thickness were thinner in vitamin C deficiency group compared with normal individuals. These findings suggested that vitamin C deficiency might play an important role in retinal and choroidal diseases.

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Vitamin C and vitamin C plus E improve the immune function in the elderly

Cited by 40 publications

References 65 publications

The Role of Immune Cells in Oxi-Inflamm-Aging

The Role of Immune Cells in Oxi-Inflamm-Aging

The Review of Anti-aging Mechanism of Polyphenols on Caenorhabditis elegans

Choroidal and Retinal Thickness in Patients with Vitamin C Deficiency

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