Vitamin B12 Levels in Senile Dementia and Confusional States

Droller, H.; Dossett, J. A.

doi:10.1159/000244550

Cited by 21 publications

(19 citation statements)

References 8 publications

(8 reference statements)

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“…[15,25] have reported low CSF concentrations of cobal amin in DAT but not in MID. In our study serum cobal amin concentrations were lower in the three patient groups as compared to the control group, but it was not statistically significant, so we can not support the find ings from other studies [12][13][14].…”

Section: Discussioncontrasting

confidence: 99%

“…Next to the liver and the kid ney, the brain contains the highest concentrations of cobalamin in the human body indicating an important role for cobalamin in the brain [9], Degenerative changes in the brain in cobalamin deficiency have been reported [10,11], A connection between dementia of Alzheimer type (DAT) and low levels of cobalamin has been sug gested by several authors [12][13][14][15], Blood A minireview of cobalamin studies in blood and CSF is presented in table 1. There are three cobalamin bind ing proteins, transcobolamin I, II and III (TC I-III) in plasma.…”

Section: Introductionmentioning

confidence: 99%

“…Marcus et al [ 19] observed an increased number of TC II binding sites for cobalamin in elderly and even more elevated in elderly with low levels of cobalamin in serum. Low cobalamin levels have been observed in DAT as com pared to control subjects or to patients with secondary dementia [12,13,20]. Regland et al [14] found low serum cobalamin levels in a group with confusional states and in a group with senile DAT as compared to patients suffering from vascular dementia and presenile DAT.…”

Section: Introductionmentioning

confidence: 99%

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Cobalamin in Blood and Cerebrospinal Fluid in Alzheimer's Disease and Related Disorders

Basun

Forsell

Bendz

et al. 1991

Dement Geriatr Cogn Disord

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Cerebrospinal fluid (CSF) and serum levels of cobalamin were studied in 35 subjects with dementia and in 7 healthy volunteers with no clinical or family history of dementia. The demented patients were classified into three groups according to DSM-III-R: dementia of Alzheimer-type (DAT), multi-infarct dementia (MID) and dementia not otherwise specified (DNOS). The CSF concentrations of cobalamin were significantly reduced in the DAT and MID cases. There were correlations between CSF and serum levels of cobalamin in the patient groups. The cobalamin levels in CSF were not related to cognitive functioning, behavior or degree of dementia, respectively. The subarachnoid spaces, ventricles and white-matter changes in the brain were observed on magnetic resonance imaging. The volumes were calculated in the DAT group, but there were no correlations to CSF or serum concentrations of cobalamin. The significance of low CSF cobalamin is discussed in relation to the metabolism of the brain.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cobalamin in Blood and Cerebrospinal Fluid in Alzheimer's Disease and Related Disorders

Basun

Forsell

Bendz

et al. 1991

Dement Geriatr Cogn Disord

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“…12); values in old age are significantly lower and decrease as age advances (30–32). Mental deterioration is associated with vitamin B 12 deficiency (33); some think that the decline in vitamin B 12 with aging is correlated with senile dementia (34). The severity of neurologic disorders is ofter unrelated to the rest of the clinical picture; occurrence and progression of neurologic impairments in the absence of anemia are common (35, 36).…”

Section: Discussionmentioning

confidence: 99%

Vitamin Profiles in Elderly Persons Living at Home or in Nursing Homes, versus Profile in Healthy Young Subjects

Baker¹,

Frank²,

Thind³

et al. 1979

J American Geriatrics Society

124

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The vitamin profile of 473 elderly persons was compared with that of 204 healthy volunteers (controls). Of the 473 elderly, 327 (mean age 87) lived in nursing homes, and 146 (mean age 77) lived at home. The 204 controls were in the 20–50 year age group. The circulating levels of biotin, pantothenate, riboflavin, vitamins A, B6, B12, C, E, folate, thiamine, nicotinate, and carotenes were determined in all groups. Hypovitaminemia was not obvious for biotin, pantothenate, riboflavin, vitamins A, E, and carotenes in either the institutional or non‐institutional elderly. Thiamine, vitamin C and vitamin B12 levels were strikingly depressed in the non‐institutional elderly as compared with the institutional population or the controls. Over 30 percent of the institutional elderly had vitamin B6 and nicotinate hypovitaminemia compared to the controls. Both the institutional and the non‐institutional elderly showed depressed levels of folate and vitamin B12. Vitamin supplementation reduced the percentage of folate and B12 deficits. The marked vitamin deficits in the institutional population, in descending order of incidence were: vitamin B6, nicotinate, vitamin B12, folate, thiamine, and ascorbate, whereas the pattern for the non‐institutional elderly was: vitamin B12, thiamine, ascorbate, vitamin B6, nicotinate, and folate. In the 473 elderly studied, vitamin B6, nicotinate, and vitamin B12, in that order, were the most common deficits; folate, thiamine and ascorbate deficits comprised a lesser percentage. The role of vitamin deficits and the effects upon the aging population are discussed.

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“…Impaired cognitive function due to pernicious anemia and low vitamin B 12 availability is well established (120). Because B 12 utilization in the elderly may be impaired due to inadequate stomach acidity (achlorhydria), decrements in kidney function, and other metabolic disorders, results of studies on intake and serum levels may seem contradictory (121,122).…”

Section: Vitamin B 12mentioning

confidence: 99%

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Vitamin B12 Levels in Senile Dementia and Confusional States

Cited by 21 publications

References 8 publications

Cobalamin in Blood and Cerebrospinal Fluid in Alzheimer's Disease and Related Disorders

Cobalamin in Blood and Cerebrospinal Fluid in Alzheimer's Disease and Related Disorders

Vitamin Profiles in Elderly Persons Living at Home or in Nursing Homes, versus Profile in Healthy Young Subjects

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