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EDITORIAL SYNOPSIS In this study of serum B12 levels in cases of liver disease normal levels were found in patients with extrahepatic biliary obstruction unless there was an associated cholangitis or intrahepatic metastases. Levels were also normal in chlorpromazine jaundice, but were consistently raised when necrosis of liver cells was present, whether necrosis was due to a virus infection or to drugs of the amine-oxidase inhibitor type.

PLATES XXVII-XXIX) '' WITCH'S MILK " is a secretion from the breasts of infants of either sex in the first few days of life. It is often accompanied by mammary hypertrophy, but, provided the breasts are left alone, the secretion dries up and their enlargement subsides within a week or two of birth. Sometimes the enlargement provokes the mother into squeezing the breasts, and Cheatle and Cutler (1931) remark on cases where secretion has been increased and maintained in this way. There is still doubt concerning the true nature of "witch's milk" and the way in which it is produced. It is thought by some to be a physiological secretion akin to lactation and to be due to the passage of maternal hormones across the placenta. Others have regarded it as a fluid resulting from liquefaction of cells when the solid cords found in the earliest stages of breast development undergo canalisation to form ducts ; according to this view the secretion is allied neither to milk nor t o colostrum.The present report concerns three cases of breast hypertrophy in infancy and the nature of the accompanying breast secretion. The first case is that of a still-born full-term male infant in whom there was breast hypertrophy without obvious secretion, the second of a 5-day-old female whose hypertrophied breasts contained a moderate amount of colostrum, the third of a 4-month-old male infant in whom a flow of true milk had been established by repeatedly expressing the breasts. CASE REPORTS Case 1A still-born male infant ; full-term delivery ; healthy mother. X'ecropsy revealed an intracranial hzemorrhage in association with a tentorial tear bnt no other abnormality of the internal organs.

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A swelling which has the clinical features of a diffuse subcutaneous lipoma is not infrequently found in the breast, and it commonly indicates underlying cancer. A true lipoma of the breast is rare. This subcutaneous swelling differs from a lipoma, which is a localized excess of adipose tissue, because the fat is normal in amount but under increased tension in the spaces between the fibrous septa which run from the superficial surface of the breast tissue to the skin. The increased pressure in the interseptal compartments produces a tumour with multiple points of attachment to the skin, a definite edge, and the consistency of fat. The word " pseudolipoma ",would seem appropriate for this lesion.One lipoma and 21 pseudolipomas were observed in a series of 480 breast conditions, 147 of them infiltrating cancers. Cancer was found in association with 18 of the pseudolipomas and duct ectasia with three. A pseudolipoma was -present in 12% of the breast cancers.