Vitamin A is not associated with exacerbations in multiple sclerosis

Runia, Tessel F.; Hop, Wim C. J.; Rijke, Yolanda B. de; Hintzen, Rogier Q.

doi:10.1016/j.msard.2013.06.011

Cited by 16 publications

(13 citation statements)

References 29 publications

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“…In the neuroinflammatory context of MS, RA showed various beneficial effects [ 95 ]. In clinical trials, supplementation of RA was not correlated with MS exacerbation [ 96 ]. On the contrary, RA enhanced the overall quantitative assessment or MS functional composite of relapsing–remitting MS patients [ 97 ].…”

Section: Efficacies Of Ra In the Treatment Of Autoimmune Diseasesmentioning

confidence: 99%

Retinoic Acid, Leaky Gut, and Autoimmune Diseases

Abdelhamid

Luo

2018

Nutrients

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A leaky gut has been observed in a number of autoimmune diseases including type 1 diabetes, multiple sclerosis, inflammatory bowel disease, and systemic lupus erythematosus. Previous studies from our laboratory have shown that lupus mice also bear a leaky gut and that the intestinal barrier function can be enhanced by gut colonization of probiotics such as Lactobacillus spp. Retinoic acid (RA) can increase the relative abundance of Lactobacillus spp. in the gut. Interestingly, RA has also been shown to strengthen the barrier function of epithelial cells in vitro and in the absence of probiotic bacteria. These reports bring up an interesting question of whether RA exerts protective effects on the intestinal barrier directly or through regulating the microbiota colonization. In this review, we will discuss the roles of RA in immunomodulation, recent literature on the involvement of a leaky gut in different autoimmune diseases, and how RA shapes the outcomes of these diseases.

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Section: Efficacies Of Ra In the Treatment Of Autoimmune Diseasesmentioning

confidence: 99%

Retinoic Acid, Leaky Gut, and Autoimmune Diseases

Abdelhamid

Luo

2018

Nutrients

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“…VitA improved the function of astrocytes, led to remyelination, and suppressed immune function in MS patients [218,269,[274][275][276][277]. In contrast, results from one study demonstrated no correlation between serum VitA concentration and the progression of MS [278].…”

Section: Vitamins In Multiple Sclerosismentioning

confidence: 91%

The Role of Vitamins in Neurodegenerative Disease: An Update

et al. 2021

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Acquiring the recommended daily allowance of vitamins is crucial for maintaining homeostatic balance in humans and other animals. A deficiency in or dysregulation of vitamins adversely affects the neuronal metabolism, which may lead to neurodegenerative diseases. In this article, we discuss how novel vitamin-based approaches aid in attenuating abnormal neuronal functioning in neurodegeneration-based brain diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, Amyotrophic lateral sclerosis, and Prion disease. Vitamins show their therapeutic activity in Parkinson’s disease by antioxidative and anti-inflammatory activity. In addition, different water- and lipid-soluble vitamins have also prevented amyloid beta and tau pathology. On the other hand, some results also show no correlation between vitamin action and the prevention of neurodegenerative diseases. Some vitamins also exhibit toxic activity too. This review discusses both the beneficial and null effects of vitamin supplementation for neurological disorders. The detailed mechanism of action of both water- and lipid-soluble vitamins is addressed in the manuscript. Hormesis is also an essential factor that is very helpful to determine the effective dose of vitamins. PubMed, Google Scholar, Web of Science, and Scopus were employed to conduct the literature search of original articles, review articles, and meta-analyses.

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“…However, they have reported a positive correlation between vitamin A and vitamin D serum level, which might be due to the patients' diet. Accordingly, it has been suggested that retinoic acid has tissue specific manner and its local production in CNS might cause relapse courses [57] , [58] . Based on these population studies, vitamin A can be considered as a significant micronutrient in pathophysiology of the disease more extended studies are needed for a strong conclusion.…”

Section: Fat Soluble Vitaminsmentioning

confidence: 99%

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis

et al. 2018

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Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease, with unknown etiology. Vitamins, as important micronutrients playing different roles in body, seem to be important in MS pathogenesis. In vitro, in vivo and human studies, supports the protective role of some vitamins in MS occurrence or progression. Current study reviews recent insights and reports about the importance of vitamins in MS incidence or progression. In accordance, the importance of all water and fat-soluble vitamins in MS pathogenesis based on observational studies in human population and their role in the function of immune system as well as possible therapeutic opportunities are discussed in depth throughout this review.

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Vitamin A is not associated with exacerbations in multiple sclerosis

Abstract: We did not find evidence for a role for vitamin A in the disease course of RRMS. We did find an association between vitamin A and D levels in the RRMS patients, possibly explained by dietary products that contain both fat-soluble vitamins.

Cited by 16 publications

References 29 publications

Retinoic Acid, Leaky Gut, and Autoimmune Diseases

Retinoic Acid, Leaky Gut, and Autoimmune Diseases

The Role of Vitamins in Neurodegenerative Disease: An Update

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis

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