Vitamin A absorption in cystic fibrosis: risk of hypervitaminosis A.

James, David; Owen, George M.; Campbell, I. A.; Goodchild, Mary C.

doi:10.1136/gut.33.5.707

Cited by 19 publications

(10 citation statements)

References 23 publications

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“…In particular, the bioavailability of lipid-soluble vitamins and oral cyclosporine (not microemulsion formulations) is reduced in patients with CF, which is attributed to reduced pancreatic lipase release (4,7,12,14,15,18,26). In addition, the volume of distribution of some drugs is altered when normalized for body weight due to the reduced adipose tissue in patients with CF.…”

mentioning

confidence: 99%

Absolute Bioavailability and Intracellular Pharmacokinetics of Azithromycin in Patients with Cystic Fibrosis

Beringer

Huynh

Kriengkauykiat

et al. 2005

Antimicrob Agents Chemother

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mentioning

confidence: 99%

Absolute Bioavailability and Intracellular Pharmacokinetics of Azithromycin in Patients with Cystic Fibrosis

Beringer

Huynh

Kriengkauykiat

et al. 2005

Antimicrob Agents Chemother

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“…Vitamin A de®-ciency in CF has been con®rmed by others [22]. However, despite the introduction of enteric coated pancreatic enzyme and oral liposoluble vitamin supplementation, serum vitamin A concentrations remain low in most patients with CF [2,12].…”

Section: Introductionmentioning

confidence: 95%

Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis

Huet

Semama

Maingueneau

et al. 1997

European Journal of Pediatrics

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“…These include direct measurement of labeled vitamin A in lymph of cannulated rats ( 3 ) or humans ( 4 ), indirect assessment based on recovery of label in feces after ingestion of an oral dose of labeled vitamin A by children ( 5 , 6 ), and determination of the isotope ratio in plasma after administration of 1 label orally and another intravenously to rats ( 7 ). In addition, area under the curve (AUC) methods have been used to estimate vitamin A and carotenoid bioavailability ( 8–12 ). None of these approaches have been extensively applied, thus limiting the data available and researchers’ confidence in it.…”

Section: Introductionmentioning

confidence: 99%

Vitamin A Absorption Efficiency Determined by Compartmental Analysis of Postprandial Plasma Retinyl Ester Kinetics in Theoretical Humans

Green

Ford

2020

The Journal of Nutrition

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ABSTRACT Background Better methods are needed for determining vitamin A absorption efficiency in humans to support development of dietary recommendations and to improve the accuracy of predictions of vitamin A status. Objectives We developed and evaluated a method for estimating vitamin A absorption efficiency based on compartmental modeling of theoretical data on postprandial plasma retinyl ester (RE) kinetics. Methods We generated data on plasma RE and retinol kinetics (30 min to 8 h or 56 d, respectively) after oral administration of labeled vitamin A for 12 theoretical adults with a range of values assigned for vitamin A absorption (55–90%); we modeled all data to obtain best-fit values for absorption and other parameters using Simulation, Analysis, and Modeling software. We then modeled RE data only (16 or 10 samples), with or without added random error, and compared assigned to predicted absorption values. We also compared assigned values to areas under RE response curves (RE AUCs). Results We confirmed that a unique value for vitamin A absorption cannot be identified by modeling plasma retinol tracer kinetics. However, when RE data were modeled, predicted vitamin A absorptions were within 1% of assigned values using data without error and within 12% when 5% error was included. When the sample number was reduced, predictions were still within 13% for 10 of the 12 subjects and within 23% overall. Assigned values for absorption were not correlated with RE AUC (P = 0.21). Conclusions We describe a feasible and accurate method for determining vitamin A absorption efficiency that is based on compartmental modeling of plasma RE kinetic data collected for 8 h after a test meal. This approach can be used in a clinical setting after fasting subjects consume a fat-containing breakfast meal with a known amount of vitamin A or a stable isotope label.

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Vitamin A absorption in cystic fibrosis: risk of hypervitaminosis A.

Cited by 19 publications

References 23 publications

Absolute Bioavailability and Intracellular Pharmacokinetics of Azithromycin in Patients with Cystic Fibrosis

Absolute Bioavailability and Intracellular Pharmacokinetics of Azithromycin in Patients with Cystic Fibrosis

Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis

Vitamin A Absorption Efficiency Determined by Compartmental Analysis of Postprandial Plasma Retinyl Ester Kinetics in Theoretical Humans

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