Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis

Huet, Frédéric; Semama, Denis S.; Maingueneau, C; Charavel, A.; Nivelon, J L

doi:10.1007/s004310050749

Cited by 26 publications

(21 citation statements)

References 16 publications

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“…One of the two pancreatic sufficient patients received 3340 IU of vitamin A daily. Previously, vitamin A deficiency was frequently reported in CF patients (Duggan et al, 1996;Huet et al, 1997;Lindblad et al, 1997). Duggan et al (1996) documented vitamin A deficiency in 8 (22.9%) out of 35 CF patients with acute exacerbations.…”

Section: Discussionmentioning

confidence: 99%

“…In the past, available evidence mainly indicated the possibility of vitamin A deficiency in CF patients (Duggan et al, 1996;Huet et al, 1997;Lindblad et al, 1997). Nowadays, routine administration of vitamin A recommended in CF patients, especially in those who are pancreatic insufficient, can help to prevent its deficiency (Kalnins and Wilschanski, 2012;Graham-Maar et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

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Vitamin A status and its determinants in patients with cystic fibrosis

Sapiejka¹,

Krzyżanowska

Walkowiak

et al. 2017

Acta Sci Pol Technol Aliment

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Background. Routine administration of vitamin A, recommended in CF patients, can help to prevent its deficiency. However, high vitamin A supplementation may lead to its excessive level and possible toxicity. Therefore, the aim of the present study was to assess the status of vitamin A and the determinants of its body resources in CF patients. Material and methods. In 196 CF patients aged from 4 months to 47 years, the following parameters were analysed: nutritional status (standardized body weight and height, serum albumin concentration) and clinical expression of disease (lung function − spirometry; biochemical markers of liver function − ALT, AST, GGT; respiratory tract colonization by Pseudomonas aeruginosa; diabetes; cirrhosis, non-cirrhotic liver disease; exocrine pancreatic function − fecal elastase-1 concentration; blood clotting -INR and vitamin A supplementation). Results. Median vitamin A concentration in the study group was 383.0 ng/ml (1

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vitamin A status and its determinants in patients with cystic fibrosis

Sapiejka¹,

Krzyżanowska

Walkowiak

et al. 2017

Acta Sci Pol Technol Aliment

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“…Poor absorption, cholestatic liver disease, or rapid turnover of carotenoids due to active inflammation could all contribute to low carotenoid levels [135,136]. However, despite severe reduction of lutein and zeaxanthin in both plasma and retina of people with CF, no related abnormalities of visual function under daylight conditions have been found [137], though poor nocturnal vision in some individuals has been corrected by retinol supplementation [138].…”

Section: Carotenoidsmentioning

confidence: 99%

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Cantin

White

Cross

et al. 2007

Free Radical Biology and Medicine

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Although great strides are being made in the care of individuals with cystic fibrosis (CF), this condition remains the most common fatal hereditary disease in North America. Numerous links exist between progression of CF lung disease and oxidative stress. The defect in CF is the loss of function of the transmembrane conductance regulator (CFTR) protein; recent evidence that CFTR expression and function are modulated by oxidative stress suggests that the loss may result in a poor adaptive response to oxidants. Pancreatic insufficiency in CF also increases susceptibility to deficiencies in lipophilic antioxidants. Finally the airway infection and inflammatory processes in the CF lung are potential sources of oxidants that can affect normal airway physiology and contribute to the mechanisms causing characteristic changes associated with bronchiectasis and loss of lung function. These multiple abnormalities in the oxidant/antioxidant balance raise several possibilities for therapeutic interventions that must be carefully assessed. IntroductionCystic fibrosis (CF) is the most common fatal disease caused by a single gene defect in Europe and North America [1,2]. The defective gene was identified in 1989 [3][4][5] and shown to encode the cystic fibrosis trans-membrane conductance regulator protein (CFTR). CFTR is a cyclic AMP-regulated anion channel with greatest selectivity for chloride, and bicarbonate [6][7][8]. Furthermore, CFTR regulates sodium transport across epithelial membranes through interactions with the epithelial sodium channel ENaC [9], and facilitates the trans-membrane export of the small organic anionic peptide glutathione [10]. The expression of CFTR is located in the apical membrane of epithelial cells that line mucous membranes and submucosal glands ☆ A list of participants may be found in the Acknowledgments.

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“…In children, manifestations of vitamin A deficiency include poor skeletal growth, hepatomegaly, increased intracranial pressure, and ocular changes (7). The ocular manifestations of hypovitaminosis A are conjunctival, and corneal xerosis, keratomalacia including ulceration, night-blindness, severe loss of visual acuity, flecked retina, and pseudotumor cerebri (2)(3)(4)(5)(6)(7)(8). Ocular changes in the published literature occur in the adolescent and early adult periods.…”

Section: Discussionmentioning

confidence: 99%

“…Ocular findings in CF mainly refer to the tear film and are related to tear hyposecretion and improper composition of tears, leading to dry-eye symptoms, considered by some authors as the primary CF eye manifestations (2)(3)(4)(5)(6). Herein, we describe an 11-month-old boy diagnosed as CF with corneal opacity.…”

mentioning

confidence: 97%

Corneal Opacity: A Rare Manifestation of Cystic Fibrosis

Pekcan¹,

Doğru²,

Köse³

et al. 2013

Respir Case Rep

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Eye manifestations due to hypovitaminosis A was observed in the follow-up of patients with cystic fibrosis. Herein, we describe an 11-month-old infant with corneal opacity and growth retardation who was diagnosed as cystic fibrosis. To our knowledge, this is the first report in the literature of corneal opacity as a manifestation of cystic fibrosis. Furthermore, it is rare to encounter ophthalmic findings in cystic fibrosis at this age

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Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis

Cited by 26 publications

References 16 publications

Vitamin A status and its determinants in patients with cystic fibrosis

Vitamin A status and its determinants in patients with cystic fibrosis

Antioxidants in cystic fibrosis☆Conclusions from the CF Antioxidant Workshop, Bethesda, Maryland, November 11-12, 2003

Corneal Opacity: A Rare Manifestation of Cystic Fibrosis

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