Corneal Opacity: A Rare Manifestation of Cystic Fibrosis

Pekcan, Sevgi; Doğru, Deniz; Köse, Mehmet; Cinel, Güzin; İrkeç, Murat; Yalçın, Ebru; Ki̇per, Nural

doi:10.5505/respircase.2013.19483

Cited by 1 publication

(1 citation statement)

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“…Compared with the index case, the symptoms were more severe and started earlier, which may be due to the variety of genotypes and phenotypes of CF. In 2012, an 11-month-old infant was reported with corneal opacity and FTT but no respiratory symptoms, being diagnosed as CF with vitamin A deficiency [ 7 ]. The index case had typical pulmonary CF symptoms along with corneal opacity, which resolved after pancreatic enzyme replacement and multivitamin supplementation.…”

Section: Discussionmentioning

confidence: 99%

Corneal opacification, an atypical presentation of cystic fibrosis: a case report and review of the literature

et al. 2022

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Background Respiratory and gastrointestinal manifestations are the main causes of mortality and morbidity in cystic fibrosis. Although these symptoms are well recognized, ophthalmic involvement of cystic fibrosis secondary to vitamin A deficiency is uncommon and has been reported very rarely in the medical literature. Case presentation Here, we report a 2.5-year-old Iranian boy who presented with bilateral corneal xerosis and corneal opacity secondary to vitamin A deficiency related to cystic fibrosis malabsorption. Conclusion Malabsorption of fat-soluble vitamins is a common presentation in cystic fibrosis, but corneal opacity secondary to vitamin A deficiency as the initial presentation of cystic fibrosis is a very rare manifestation of fat malabsorption. This highlights the importance of complete systemic examination besides ophthalmic examination in approaching a child with ophthalmic complaint.

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Section: Discussionmentioning

confidence: 99%