1983
DOI: 10.1079/bjn19830107
|View full text |Cite
|
Sign up to set email alerts
|

Vitamin A absorption and metabolism in the chick: response to high dietary intake and to tocopherol

Abstract: 1. Absorption of 14C-labelled retinol was determined along the gastrointestinal tract of chicks, using 141Cerium as a non-absorbed reference substance, as influenced by high dietary vitamin A and the addition of tocopherol to the diet.2. The site of major vitamin A absorption was the proximal small intestine and high intake of vitamin A reduced slightly the percentage over-all absorption.3. Labelled glucuronides were secreted into the duodenum and were 5&60% reabsorbed in the small intestines. High-vitamin-A i… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
10
0

Year Published

1985
1985
2017
2017

Publication Types

Select...
6
2

Relationship

1
7

Authors

Journals

citations
Cited by 22 publications
(11 citation statements)
references
References 25 publications
(25 reference statements)
1
10
0
Order By: Relevance
“…The serum a-tocopherol (vitamin E) concentration has been positively associated w i t h the level of serum retinol (vitamin A) (Rahim et al, 1993). Thus the observation that plasma a-tocopherol concentration shows a positive correlation with the ponderal index (Herbeth et al, 1988) may be direct, but as vitamin E exerts a sparing effect on vitamin A by reducing its turnover, and increasing liver storage (Sklan, 1983), indirect effects can not be ruled out. Vitamin C plays a critical role as a tissue antioxidant in its own right, but is also effective in reducing vitamin E radicals, thereby regenerating vitamin E in a functional form to act as lipid antioxidant (Packer et al, 1979).…”
Section: Introductionmentioning
confidence: 94%
“…The serum a-tocopherol (vitamin E) concentration has been positively associated w i t h the level of serum retinol (vitamin A) (Rahim et al, 1993). Thus the observation that plasma a-tocopherol concentration shows a positive correlation with the ponderal index (Herbeth et al, 1988) may be direct, but as vitamin E exerts a sparing effect on vitamin A by reducing its turnover, and increasing liver storage (Sklan, 1983), indirect effects can not be ruled out. Vitamin C plays a critical role as a tissue antioxidant in its own right, but is also effective in reducing vitamin E radicals, thereby regenerating vitamin E in a functional form to act as lipid antioxidant (Packer et al, 1979).…”
Section: Introductionmentioning
confidence: 94%
“…Once sufficient intake of vitamin A is achieved no change in growth or laying is observed over a 10-fold increase in vitamin A intake. Intakes of vitamin A at levels approximately 50 times greater then requirements give rise to increases in circulating retinyl esters together with signs of toxicity including membranolytic changes and skin lesions (Kriz and Holman, 1969;Sklan, 1983;Bondi and Sklan, 1984).…”
Section: Vitamin a Nutriture In Birdsmentioning
confidence: 99%
“…This approach was based on previous observations that a high intake of vitamin A increased tocopherol turnover, and high tocopherol levels ameliorated the effects of toxic levels of vitamin A (Sklan and Donoghue, 1982;Sklan, 1983). The findings indicate that increased tocopherol nutriture partially protected antibody production in high intakes of dietary vitamin A (Friedman, Bartov, Heller and Sklan, unpublished observations).…”
Section: Excess D I E T a Y Vitamin A Levelsmentioning
confidence: 99%
See 1 more Smart Citation
“…In the intestinal mucosa a copper-containing dioxygenase (Goodman et aL, 1967;Sklan, 1983a) catalyses cleavage of the carotene molecule at C-15, yielding retinal. A zinc-containing retinene reductase, or alcohol dehydrogenase, then reduces the retinal to retinol.…”
Section: Intestinal Absorption and Conversion Of ß-Carotene To Retinolmentioning
confidence: 99%