Visualization of irrigation fluid flow and calculation of its velocity distribution in the anterior chamber by particle image velocimetry

Kaji, Yuichi; Yamashita, M.; Sakakibara, Jun; Oshika, Tetsuro

doi:10.1007/s00417-012-1953-4

Cited by 8 publications

(5 citation statements)

References 15 publications

(21 reference statements)

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“…Two typical inflow positions in PC were considered: along the pupillary margin; at the root of PC. Figure 2 is the scheme of these two conditions, in the left diagram, inflow point is along the pupillary margin; in the right diagram, inflow point is at the root of PC [13,19]. …”

Section: Methodsmentioning

confidence: 99%

“…As a whole flow field measurement system, PIV can be intuitive and non-interfering to the flow field of target observation area [11,12]. It is a relatively new attempt to introduce PIV to intraocular aqueous humor flow study [13]. This method enables visualization of the direction and calculation of the velocity of fluid flow by analyzing pairs of images of small particles captured at short intervals.…”

Section: Introductionmentioning

confidence: 99%

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Experimental research on intraocular aqueous flow by PIV method

et al. 2013

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BackgroundAqueous humor flows regularly from posterior chamber to anterior chamber, and this flow much involves intraocular pressure, the eye tissue nutrition and metabolism.PurposeTo visualize and measure the intraocular flow regular pattern of aqueous humor.MethodIntraocular flow in the vitro eyeball is driven to simulate the physiological aqueous humor flow, and the flow field is measured by Particle Image Velocimetry(PIV). Fluorescent particle solution of a certain concentration was infused into the root of Posterior Chamber(PC) of vitro rabbit eye to simulate the generation of aqueous and was drained out at a certain hydrostatic pressure from the angle of Anterior Chamber(AC) to represent the drainage of aqueous. PIV method was used to record and calculate the flow on the midsagittal plane of the eyeball.ResultsVelocity vector distribution in AC has been obtained, and the distribution shows symmetry feature to some extent. Fluorescent particle solution first fills the PC as it is continuously infused, then surges into AC through the pupil, flows upwards toward the central cornea, reflecting and scattering, and eventually converges along the inner cornea surface towards the outflow points at the periphery of the eyeball. Velocity values around the pupillary margin are within the range of 0.008-0.012 m/s, which are close to theoretical values of 0.0133 m/s, under the driving rate of 100 μl/min.ConclusionsFlow field of aqueous humor can be measured by PIV method, which makes it possible to study the aqueous humor dynamics by experimental method. Our study provides a basis for experimental research on aqueous humor flow; further, it possibly helps to diagnose and treat eye diseases as shear force damage of ocular tissues and destructions on corneal endothelial cells from the point of intraocular flow field.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experimental research on intraocular aqueous flow by PIV method

et al. 2013

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“…Convection occurring in the lens capsule during I/A has been reported previously, indicating that convection of I/A in the capsule affects the behavior of the IOL. 19 , 20 It has also been documented that during the actual I/A procedure, the IOL rotates while unfolding in the lens capsule. 21 In a previous report, we mentioned that the behavior of the IOL within the lens sac during I/A might affect the amount of residual OVD.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Residual Amount of an Ophthalmic Viscosurgical Device Among Different Types of Intraocular Lens Implants in vitro

Oki,

Horiguchi,

Terauchi

et al. 2024

OPTH

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Purpose Although ophthalmic viscosurgical devices are quite important for safe cataract surgery, currently, postoperative residual ophthalmic viscosurgical devices can cause various complications. Previously, we developed a method to visualize residual ophthalmic viscosurgical devices after irrigation/aspiration in vitro and found that the amount of residual ophthalmic viscosurgical device on a single-piece intraocular lens was greater than that on a three-piece intraocular lens. In the present study, we compared the amounts of residual ophthalmic viscosurgical device among various foldable intraocular lenses to investigate the factors that determine the quantity of residual ophthalmic viscosurgical device. Patients and Methods Simulated cataract surgery was performed in pig eyes using an ophthalmic viscosurgical device labeled with fluorescent silica particles. After the simulated surgery procedure, the fluorescent silica attached to the intraocular lens was observed and quantified by inductively coupled plasma-atomic emission spectrometry after intraocular lens removal. The amount of residual ophthalmic viscosurgical device was compared among five representative single-piece intraocular lenses and one three-piece intraocular lens. Results The distribution and amount of the residual ophthalmic viscosurgical device differed for each intraocular lens. The amount of silicon in the lens capsule differed among the intraocular lens types. Conclusion The postoperative residual tendency of ophthalmic viscosurgical devices differed among various single-piece intraocular lenses. The behavior of the intraocular lenses within the capsule affected the residual tendency. The removal of ophthalmic viscosurgical device in the lens capsule should be tailored for each intraocular lens to improve efficiency.

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“…Kaji et al performed an experimental study to visualize irrigation fluid flow and calculate its velocity distribution in the anterior chamber during phacoemulsification without ultrasound by particle image velocimetry. 25 The tip of an ultrasound handpiece was inserted into the anterior chamber of porcine eyes through a corneal incision. Irrigation fluid was mixed with fluorescein-labeled liposomes as tracer particles, which could be illuminated by a laser with images captured with a CCD camera.…”

Section: Discussionmentioning

confidence: 99%