Visual outcome following optic neuritis: A 5-year review

Pedro-Egbe, CN; Fiebai, Bassey; Ejimadu, CS

doi:10.4103/1119-3077.100628

Cited by 6 publications

(7 citation statements)

References 18 publications

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“…Other studies which included ON patients of all ages also reported better outcomes than our observation. A study of 27 native African patients conducted in Nigeria reported initial BCVA ≤ 20/200 in 60% and only 9% at 12-week follow-up [ 7 ]. However, the study only included 1 patient who was older than 50 years.…”

Section: Discussionmentioning

confidence: 99%

“…In ON patients, ethnicity has been documented as an important factor influencing clinical features and the outcome [ 6 ]. It has been identified that NMOSD is more likely to develop in Asia, whereas MS is more prevalent in western countries [ 7 ]. Previously, we reported a cohort of Chinese ON patients with atypical clinical features and poor recovery [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Wang

Zhou

Qin

et al. 2017

Journal of Ophthalmology

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Objective This study aims to describe the clinical manifestations and outcomes in a cohort of older Chinese patients. Method A retrospective study of patients aged ≥ 45 years who had a first episode of optic neuritis (ON) between May 2008 and November 2012. Clinical features at onset and last follow-up were analyzed within subgroups (age 45–65 years and age ≥ 65 years). Results 76 patients (99 eyes) were included, of which 58% were females. The mean age at presentation was 55.53 ± 8.29 years (range: 45–83 years). Vision loss was severe at presentation, with initial best corrected vision activity (BCVA) < 20/200 in 93% and final BCVA < 20/200 in 53% of patients at 5-year follow-up. Final BCVA significantly correlated with the initial BCVA and peripapillary retinal nerve fiber layer. At last follow-up, 14.5% were diagnosed with neuromyelitis optica spectrum disorder (NMOSD), 1.3% were diagnosed with multiple sclerosis (MS), 5.2% with chronic relapsing inflammatory optic neuropathy, 1.3% with infectious ON, and 19.7% with autoimmune ON. None of the elderly group (≥65 years) developed NMOSD or MS. Conclusion Chinese patients in the age group ≥ 65 years with ON are less likely to develop NMOSD or MS. Notwithstanding, they had more severe visual loss at onset and poor recovery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Wang

Zhou

Qin

et al. 2017

Journal of Ophthalmology

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“…Optic neuritis is one of the most common causes of acute visual loss in the young population [ 2 , 20 ]. Visual acuity spontaneously increases over days and weeks, but the improvement is completed almost in 2 or 3 months [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Optic neuritis (ON) is an acute demyelinating inflammatory disease of the optic nerve and primarily influences young females [ 1 , 2 ]. It is usually related to multiple sclerosis (MS) or neuromyelitis optica (NMO) or can be seen isolated [ 2 ]. It is observed after paranasal sinuses infections or viral infections [ 3 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis

Güçlü

Özal

Gürlü

et al. 2015

Journal of Ophthalmology

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Purpose. To demonstrate the relation between optic neuritis (ON) and systemic inflammation markers as neutrophil lymphocyte ratio (N/L ratio), platelet count, mean platelet volume (MPV), and red cell distribution width (RDW) and furthermore to evaluate the utilization of these markers to predict the frequency of the ON episodes. Methods. Forty-two patients with acute ON and forty healthy subjects were enrolled into the study. The medical records were reviewed for age, sex, hemoglobin (Hb), Haematocrit (Htc), RDW, platelet count, MPV, white blood cell count (WBC), neutrophil and lymphocyte count, and neutrophil lymphocyte ratio (N/L ratio). Results. The mean N/L ratio, platelet counts, and RDW were significantly higher in ON group (p = 0.000, p = 0.048, and p = 0.002). There was a significant relation between N/L ratio and number of episodes (r = 0.492, p = 0.001). There was a statistically significant difference for MPV between one episode group and recurrent ON group (p = 0.035). Conclusions. Simple and inexpensive laboratory methods could help us show systemic inflammation and monitor ON patients. Higher N/L ratio can be a useful marker for predicting recurrent attacks.

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“…6 The outcome of optic neuritis in the Asian countries has been shown to be poorer than the west. 7,[9][10][11][12][13][14][15][16][17] There are a few studies from developing countries in Asia and Africa which have shown similar visual outcomes as the Optic Neuritis Treatment Trial and conflict with the other studies from similar geographic locations. 8,18 A study on optic neuritis from India has shown a clinical profile and outcome similar to majority of studies from the Asian continent and significantly different from the West.…”

Section: Clinical Profile and Visual Outcomementioning

confidence: 99%

Visual Outcome and Prognostic Factors of Optic Neuritis: A Perspective from the East

Singh¹

2016

DJO

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Optic neuritis is an inflammatory disorder of the optic nerve often resulting in a demyelination process. In the west and in Caucasian populations, the optic neuritis treatment trial demonstrated good recovery and excellent visual outcomes with a significant risk of conversion into multiple sclerosis. However recent reports from the Asian and African continents have noted a significantly different clinical profile and outcomes are reported to be worse than the West. Prognostic factors for visual recovery in optic neuritis have been found to include visual acuity at presentation, clinical signs in the form of retrobulbar pain and disc edema, race and ethnicity, age and retinal thinning on OCT. The risk of conversion to multiple sclerosis is low and values ranging from 0-5% have been reported in various studies. This review collates information about optic neuritis from the Eastern part of the world with regard to clinical profile, visual outcome, prognostic factors and risk of conversion to multiple sclerosis.

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Visual outcome following optic neuritis: A 5-year review

Cited by 6 publications

References 18 publications

Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Elevated Neutrophil Lymphocyte Ratio in Recurrent Optic Neuritis

Visual Outcome and Prognostic Factors of Optic Neuritis: A Perspective from the East

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