Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Wang, Junqing; Zhou, Huanfen; Qin, Linling; Peng, Chunxia; Zhao, Jie; Teng, Da; Lin, Dasheng; Ai, Nanping; Xu, Quangang; Wei, Shihui

doi:10.1155/2017/3458356

Cited by 6 publications

(15 citation statements)

References 31 publications

(33 reference statements)

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“…The etiologies were generally similar to those observed in other Asian countries. [23][24][25][26][27] The results were also comparable to those reported in Chiangmai, which lies in northern Thailand. 28 A slight difference is that the number of MS cases was relatively higher in Chiangmai Province.…”

Section: Discussionsupporting

confidence: 79%

“…In China, the most frequent etiology was idiopathic according to Zhang et al 23 Other autoimmune disorders and NMOSD were common etiologies in another Chinese series. 24 Chinese patients ≥ 65-year-old were less likely to develop NMOSD or MS. They experienced severe visual loss and a poor visual prognosis.…”

Section: Discussionmentioning

confidence: 92%

“…They experienced severe visual loss and a poor visual prognosis. 24 Japanese and Korean studies revealed that the most common etiology was idiopathic, followed by NMOSD, MOGAD and MS. 25 , 26 The proportion of MS in these studies was relatively low. Meanwhile, the majority of South African patients with immune-mediated ON developed idiopathic-ON with atypical features.…”

Section: Discussionmentioning

confidence: 99%

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Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients

Vanikieti

Janyaprasert

Lueangram

et al. 2020

OPTH

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Purpose: To analyze the demographic patterns, clinical characteristics and etiologies of acute optic neuritis (ON). Methods: This retrospective observational study included patients with acute ON who presented to a university hospital in Bangkok, Thailand, between January 2010 and March 2020. The demographic details, clinical characteristics and etiologies of acute ON were evaluated. Results: A total of 171 patients were included in the study (78.4% [n=134] female; mean age 45 years [standard deviation 15.4 years]; 32.2% [n=55] bilateral involvement). The most common type of acute ON was idiopathic (51.5%), followed by neuromyelitis optica spectrum disorder (NMOSD, 30.9%), other autoimmune disorders (9.9%), myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD, 5.3%), multiple sclerosis (MS, 1.8%), and postinfection (0.6%). In the other autoimmune disorders group, 2 patients developed systemic lupus erythematosus (1.2%), 2 Sjogren's syndrome (1.2%), 1 RA (0.6%), 1 anti-NMDAR (0.6%), 3 anti-Jo1 (1.8%), 2 c-ANCA (1.2%), 1 anti-centromere (0.6%), and 5 nonspecific autoimmune disorders (2.9%). In the idiopathic group, 38.6% developed single isolated ON, 1.8% relapsing isolated ON and 11.1% chronic relapsing inflammatory optic neuropathy. Conclusion: The most common form of acute ON in this study, similar to other Asian countries, was idiopathic. Idiopathic-ON shared some phenotypes with NMOSD and MOGAD. We also reported patients with anti-NMDAR, anti-Jo1, c-ANCA and anti-centromere disorders. Improvements in antibody detection have widened the range of possible etiologies of acute ON. The study highlighted the important role of antibodies in creating effective treatments in the future.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients

Vanikieti

Janyaprasert

Lueangram

et al. 2020

OPTH

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“…Our cohort was similar to several previous studies in terms of AQP4 serostatus, female predominance, age at first episode of ON in each affected eye, laterality. 1,10,[15][16][17][18][19][20][21][22][23][24] Most of the affected eyes (37 eyes, 58.6%) in our study presented with BCVA at nadir < 20/400. This result was fairly similar to several other studies, which provides additional evidences that NMOSD-ON is typically severe.…”

Section: Discussionmentioning

confidence: 53%

Prognostic Factors for Visual Outcomes Following the First Episode of NMOSD-Related Optic Neuritis in Affected Eyes

Thongmee¹,

Padungkiatsagul²,

Jindahra³

et al. 2020

OPTH

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Objective: We aim to identify prognostic factors for visual outcomes following a first episode of neuromyelitis optica spectrum disorder-related optic neuritis (NMOSD-ON) in affected eyes. Materials and Methods: This was a single-center, retrospective study. The study included 50 individuals who were diagnosed with NMOSD-ON (63 affected eyes) in a tertiary institution over a 12-year period. Data regarding any second, or higher, episodes of NMOSD-ON in each eye were not taken into consideration. Medical records of included individuals were reviewed. Demographic data, clinical and magnetic resonance imaging characteristics, and treatment outcomes were collected. Main outcome measures of the study were prognostic factors for good visual outcome (best-corrected visual acuity (BCVA) ≥ 20/200) following an initial episode of NMOSD-ON in affected eyes. Results: Sixty-three affected eyes of 50 individuals (3 men and 47 women) were included. BCVA at nadir that was better than counting fingers (CF) (odds ratio 10.43, 95% confidence interval 1.04, 104.45, p = 0.046) and time from NMOSD-ON onset to intravenous methylprednisolone (IVMP), less than 21 days (odds ratio 10.73, 95% confidence interval 1.91, 60.01, p = 0.007), were significantly associated with good visual outcomes. Conclusion: BCVA at nadir that was better than CF and treatment with IVMP within 21 days of symptom onset were important prognostic factors of good visual outcomes following a first episode of NMOSD-ON in affected eyes.

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“…Demyelinating inflammatory diseases are the most common cause of ON, which is usually associated with multiple sclerosis (MS) and neuromyelitis optica (NMO) or can occur in isolated episodes [ 1 ]. MS is more common in Western countries, whereas NMO has a higher prevalence in Asia [ 2 ]. Infection is also another important etiology of ON that needs to be considered [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Clinical Profile of Optic Neuritis in Malaysian Patients Older Than 45 Years of Age

Hudzaifah-Nordin¹,

Wendy-Ong²,

Nurul-Ain³

et al. 2022

Cureus

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Introduction Optic neuritis (ON) is a blinding inflammatory disease of the optic nerve, typically affecting young adults as described in the Optic Neuritis Treatment Trial (ONTT). However, there is limited information describing ON in patients older than 45 years of age. The aim of this study was to determine the clinical profile of ON in this age group in Malaysia. Methods A retrospective case series study was performed between January 2014 and December 2018 among patients older than 45 years old, treated as ON in Hospital Universiti Sains Malaysia, Kelantan, Malaysia. Clinical features, visual acuity, imaging, laboratory results, aetiologies, and visual outcomes were analyzed. Results This study comprised 17 patients (20 eyes) with a gender distribution of eight males and nine females. The mean age of ON onset was 55.8 ± 7.7 years (46-80 years). Most patients (94.1%) presented with reduced vision and retroorbital pain, and three patients (17.6%) had bilateral eye involvement. Papillitis was observed in 13 eyes (65%), retrobulbar ON in five eyes (25%), and optic atrophy in two eyes. Presenting visual acuity was moderately correlated with final visual outcome (rs= 0.47, n = 20, p < 0.05). Post-treatment visual improvement (good and slight) was reported in 14 eyes (70%), four (20%) had no improvement while the remaining two eyes (10%) had worsening best-corrected visual acuity (BCVA). Infective causes accounted for 23.5% of cases (one ocular syphilis, two ocular tuberculosis, and one case of toxoplasmosis). Most cases (70.6%) were idiopathic ON, and only one case was diagnosed with neuromyelitis optica spectrum disorder (NMOSD). Conclusion ON in Malaysian patients older than 45 years of age has no gender predilection and is most likely to be idiopathic; however, infective ON must still be ruled out. Overall visual outcomes were satisfactory. Among the infective causes, ocular tuberculosis caused poor visual recovery as compared with syphilitic and toxoplasmosis-related ON cases.

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Optic Neuritis in the Older Chinese Population: A 5-Year Follow-Up Study

Cited by 6 publications

References 31 publications

<p>Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients</p>

<p>Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients</p>

<p>Prognostic Factors for Visual Outcomes Following the First Episode of NMOSD-Related Optic Neuritis in Affected Eyes</p>

Clinical Profile of Optic Neuritis in Malaysian Patients Older Than 45 Years of Age

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