&lt;p&gt;Etiologies of Acute Optic Neuritis in Thailand: An Observational Study of 171 Patients&lt;/p&gt;

Vanikieti, Kavin; Janyaprasert, Pavarut; Lueangram, Sirin; Nimworaphan, Jirat; Rattanathamsakul, Natthapon; Tiraset, Nanida; Chokthaweesak, Wimonwan; Samipak, Narong; Padungkiatsagul, Tanyatuth; Preechawat, Pisit; Poonyathalang, Anuchit; Pulkes, Teeratorn; Tunlayadechanont, Supoch; Siriyotha, Sukanya; Jindahra, Panitha

doi:10.2147/opth.s271820

Cited by 3 publications

(7 citation statements)

References 45 publications

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“…104,109,110 In recent large cohort studies applying 2017 criteria for MS, the proportion of ON associated with MS varies from 14%-28% at first diagnosis, 104,105 to 33%-57% after varied follow-up periods. [103][104][105] In Asian populations, the proportion of ON associated with MS at first diagnosis (from 2% to 16%) 54,102,111 and the conversion rate to MS after isolated ON (3%-18% after 5 years) are lower than in non-Asian populations. 100,102,[112][113][114] Other etiologies.…”

Section: Epidemiology Of On With Current Diagnosis Criteriamentioning

confidence: 99%

“…115 The proportion of CRION cases may be approximately 2%-10% of ON cases, many of them have simultaneous MOG seropositivity. 111,116,117 The proportions of other ON etiologies are lower and not well known. The few studies that counted them found less than 2%.…”

Section: Epidemiology Of On With Current Diagnosis Criteriamentioning

confidence: 99%

“…The few studies that counted them found less than 2%. [102][103][104][105]111 Systemic and infectious diseases are rare given the frequency of this complication, and the global incidence of each disease: 0.8% for GPA 118 (incidence 1.4 per 100,000 119 ); 1% for SLE 52 (23 per 100,000 120 ); 0.2% for Sjögren's syndrome 121 (3-11 per 100,000 122 ); 0.5% for sarcoidosis 123 (10-65 per 100,000 61,123 ); 5%-10% for cat-scratch disease (4.7 per 100,000) 68 ; 0.4% for Herpes Zoster Ophthalmicus 72 (31 per 100,000 124 ); 2%-5% for syphilis, 71 or perhaps more with systematic examination of asymptomatic patients 125 (7.5 per 100,000 70 ); a few casereports for Lyme disease and other infectious diseases. 59 Many of these causes can be easily excluded.…”

Section: Epidemiology Of On With Current Diagnosis Criteriamentioning

confidence: 99%

“…The remaining CIS cases correspond to isolated ON (negative CSF and MRI analyses), and "possible MS" (positive CSF or MRI analyses without meeting MS criteria), and may represent 10%-67% of ON cases according to length of follow-up. 99,[103][104][105]111,126,127 Overall, the four main causes of ON are (possible) MS (especially in non-Asian populations), NMOSD AQP4-IG+ (especially in Asian population), MOGAD, and isolated ON.…”

Section: Epidemiology Of On With Current Diagnosis Criteriamentioning

confidence: 99%

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Optic neuritis classification in 2021

Ducloyer¹,

Marignier

Wiertlewski³

et al. 2021

European Journal of Ophthalmology

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Optic neuritis (ON) can be associated with inflammatory disease of the central nervous system or can be isolated, with or without relapse. It can also be associated with infectious or systemic disease. These multiple associations based on a variety of clinical, radiological, and biological criteria that have changed over time have led to overlapping phenotypes: a single ON case can be classified in several ways simultaneously or over time. As early, intensive treatment is often required, its diagnosis should be rapid and precise. In this review, we present the current state of knowledge about diagnostic criteria for ON aetiologies in adults and children, we discuss overlapping phenotypes, and we propose a homogeneous classification scheme. Even if distinctions between typical and atypical ON are relevant, their phenotypes are largely overlapping, and clinical criteria are neither sensitive enough, nor specific enough, to assure a diagnosis. For initial cases of ON, clinicians should perform contrast enhanced MRI of the brain and orbits, cerebral spinal fluid analysis, and biological analyses to exclude secondary infectious or inflammatory ON. Systematic screening for MOG-IgG and AQP4-IgG IgG is recommended in children but is still a matter of debate in adults. Early recognition of neuromyelitis optica spectrum disorder, MOG-IgG-associated disorder, and chronic relapsing idiopathic optic neuritis is required, as these diagnoses require therapies for relapse prevention that are different from those used to treat multiple sclerosis.

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Section: Epidemiology Of On With Current Diagnosis Criteriamentioning

confidence: 99%

Section: Epidemiology Of On With Current Diagnosis Criteriamentioning

confidence: 99%

Section: Epidemiology Of On With Current Diagnosis Criteriamentioning

confidence: 99%

Section: Epidemiology Of On With Current Diagnosis Criteriamentioning

confidence: 99%

See 2 more Smart Citations

Optic neuritis classification in 2021

Ducloyer¹,

Marignier

Wiertlewski³

et al. 2021

European Journal of Ophthalmology

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“… 3 , 4 Correspondingly, idiopathic-ON is the most common etiology of ON in Thais (51.5%), followed by neuromyelitis optica spectrum disorder (NMOSD, 30.9%), autoimmune disorder (9.9%), myelin oligodendrocyte glycoprotein antibody-associated disorder (MOGAD, 5.3%), multiple sclerosis (MS, 1.8%), and postinfection (0.6%). 5 …”

Section: Introductionmentioning

confidence: 99%

Serum Vitamin D Levels and Status in Thai Optic Neuritis Subjects: A Case-Control Study

Puangsricharoen¹,

Vanikieti²,

Jindahra³

et al. 2022

OPTH

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Objective To measure serum total vitamin D or 25-hydroxyvitamin D [25(OH)D] levels and status in immune-based optic neuritis (ON) including neuromyelitis optica spectrum disorder (NMOSD)-ON, myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD)-ON, autoimmune-ON, and idiopathic-ON and compare them with age- and sex-matched healthy controls. The secondary objective was to analyze the association between serum 25(OH)D levels and ON attack severity (nadir best-corrected visual acuity; nadir BCVA). Materials and Methods This was a single-center, case–control study. We enrolled 59 subjects (19 NMOSD-ON, 6 MOGAD-ON, 11 autoimmune-ON, 23 idiopathic-ON) diagnosed with acute immune-based ON (any ON attacks) over 11 years. Electronic medical records were reviewed and demographic data (age at sampling, sex, aquaporin-4 immunoglobulin (AQP4-IgG); myelin oligodendrocyte glycoprotein immunoglobulin G (MOG-IgG); other biomarkers of autoimmune disorders), ON attack severity (nadir BCVA), and serum 25(OH)D levels in the acute phase of ON were collected. Serum 25(OH)D levels of 236 age- and sex-matched healthy controls were assessed. Results Mean serum 25(OH)D levels were significantly lower in each group of immune-based ON compared with healthy controls ( p < 0.001 for each ON group). However, mean serum 25(OH)D levels were not significantly different between four ON groups (NMOSD-ON, 20.18±5.90 ng/mL; MOGAD-ON, 23.07±4.94 ng/mL; autoimmune-ON, 21.14±5.29 ng/mL; idiopathic-ON, 19.56 ±5.12 ng/mL; p = 0.525). All immune-based ON subjects had vitamin D insufficiency or vitamin D deficiency. The prevalences of vitamin D insufficiency and vitamin D deficiency were significantly higher than in healthy controls in each ON group (both p < 0.05 in each ON group). No associations were observed between serum 25(OH)D levels and ON attack severity (nadir BCVA). Conclusions Thai immune-based ON subjects had lower serum 25(OH)D levels and higher prevalence of vitamin D insufficiency and vitamin D deficiency compared with age- and sex-matched healthy controls. Serum 25(OH)D levels were not associated with ON attack severity (nadir BCVA). We highly recommend that serum 25(OH)D levels be screened in all subjects with acute immune-based ON.

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