Visual Outcome and Prognostic Factors of Optic Neuritis: A Perspective from the East

Singh, Digvijay

doi:10.7869/djo.180

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…Their study supports the need for early treatment and contradicts the results of the Optic nerve treatment trial 15 . While previous study mentioned that absence of retroorbital pain has been shown to result in a poorer visual outcome as compared to patients with retro-orbital pain 16 . According to Du Y et al disc swelling is another important parameter which has been evaluated as a prognostic marker for visual outcome.…”

Section: Discussionmentioning

confidence: 83%

Clinical Spectrum of Neuritis Optic Patients Receiving Intravenous Corticosteroid Treatments in Doctor Kariadi Hospital Semarang

Sativa¹,

Prihatningtias²

2021

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Introduction and Objective: Optic neuritis is inflammation of the optic nerve leading to sudden loss of vision that takes place over several hours or days. Corticosteroids have been widely used in the treatment of optic neuritis due to their anti-inflammatory effects. This study aimed to retrospectively review cases of optic neuritis that have been the administration of intravenous corticosteroid treatment on visual acuity. Methods: The authors conducted a retrospective study of patients who underwent 3 days of intravenous corticosteroid therapy for neuritis optic from January 2018 to December 2018 in Kariadi Hospital. The data collected included patient demographics, onset, clinical examinations, and visual acuity. Result: The authors included 22 eyes from 16 patients who received intravenous corticosteroid treatment for 3 consecutive days during the study period. The study found a mean age of 32,91±9,32 years (18-49 years). The mean onset was 2,36±3,07 months (0,1-12 months). Ten eyes (45,5%) had positive RAPD and five eyes (22,7%) had ocular movement pain. Thirteen patients (59,1%) had papil edema in funduscopy examination. Fourteen eyes (63,6%) had visual acuity at or below 6/60 at the time of presentation. The mean visual acuity at the time of presentation was 2,45±1,79 LogMar units (Range 0,2-5,0 LogMar units). After three days of intravenous corticosteroid treatment, the mean visual acuity was 1,81±1,42 LogMar units (Range 0,1-5,0 LogMar units). The visual acuity before and after treatment were analyzed using the Wilcoxon test and gave p=0,004 as result. Conclusion: Treatment of intravenous corticosteroid commonly gave a better visual acuity on neuritis optic patients. There are no significant differences of onset and clinical examinations in intravenous corticosteroid treatment visual outcome.

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Section: Discussionmentioning

confidence: 83%

Clinical Spectrum of Neuritis Optic Patients Receiving Intravenous Corticosteroid Treatments in Doctor Kariadi Hospital Semarang

Sativa¹,

Prihatningtias²

2021

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“…5 Prognostic factors of visual recovery in ON are visual acuity at presentation, race, ethnicity, comorbidities, ocular signs such as retro bulbar pain, optic disc edema, and retinal thinning in optical coherence tomography (OCT). 6 OCT is a rapid, non-invasive, non-contrast, transpupillary, and reproducible imaging technique using low coherence interferometry to produce cross-sectional images of the retina and optic nerve head (ONH) with high temporal accuracy. 7 Its capacity to depict the ONH, peripapillary retinal nerve fiber layer (RNFL), and cellular layers of the macula enables quantitative and qualitative assessment of optic nerve diseases.…”

Section: Introductionmentioning

confidence: 99%

An analytical longitudinal observational study on the association of Vitamin D insufficiency in subjects with primary (idiopathic) demyelinating optic neuritis using visual evoked potential and optical coherence tomography

Nirja Agasti,

Amar Kumar Misra,

Mandal

et al. 2024

Asian J Med Sci

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Background: Optic neuritis (ON) is an acute and often immune-mediated inflammatory condition of the optic nerve. Vitamin D acts as an anti-inflammatory agent and may confer neuroprotection. Visual evoked potential (VEP) and optical coherence tomography (OCT) are emerging tools for demyelinating diseases. Aims and Objectives: We tried to correlate between Vitamin D insufficiency and acute demyelinating ON using different parameters such as VEP, ganglion cell layer (GCL) thickness, and retinal nerve fiber layer (RNFL) thickness. Materials and Methods: This observational longitudinal analytical study included thirty non-consecutive patients with primary ON and 30 healthy controls. All patients with ON underwent detailed clinical and ophthalmological examination, and detailed blood workup, including serum 25 (OH) Vitamin D. VEP P100 latency, amplitude, OCT, RNFL thickness, and GCL thickness at presentation and after 3 months from May 2019 to November 2020. Results: Vitamin D insufficiency (below 30 ng/mL) was present in 60% of cases of ON. The baseline VEP showed significantly prolonged P100 latency in affected eyes in the Vitamin D insufficient group (mean 129.78±7.97 ms vs. 121.0±4.99 ms) whereas the P100 amplitude was not significantly altered between the two groups (5.5±3.13 μV vs. 7.08±3.01 μV). The baseline RNFL thickness (132.21±10.69 μm vs. 118.01±10.4 μm) and GCL thickness (76.82±2.04 μm vs. 73.06±3.2 μm) were greater in affected eyes of vitamin D insufficiency ON. There was greater RNFL thinning (79.93±3.42 μm vs. 74.80±3.5 μm) and GCL thinning (64.78±1.9μm vs. 69.02±2.22 μm) in affected eyes of ON with Vitamin D insufficiency at 3 months. Conclusion: Vitamin D insufficiency was found in most cases of ON. Insufficient Vitamin D positively correlated with optic nerve affection severity as evidenced by significantly increased baseline thickness of RNFL and GCL and more thinning of RNFL and GCL at the end of 3 months of follow-up.

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“…1 It has been observed that the clinical profile and outcome of optic neuritis among adults in the Western population differs significantly from that in the East and this may hold true for pediatric optic neuritis. 2 The purpose of this study is to retrospectively review the cases of optic neuritis among a population of less than 20 years of age at a tertiary care hospital in order to understand the various clinical aspects of these patients and compare it with the Caucasian population.…”

Section: Introductionmentioning

confidence: 99%

Clinical Spectrum of Pediatric Optic Neuritis in Indian Children

Singh¹,

Phuljhele²,

Sharma³

et al. 2017

Ophthalmol Open J

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Purpose: To study the clinical spectrum of pediatric optic neuritis in Indian children at a tertiary care centre. Methods: A retrospective study of patients diagnosed with optic neuritis below 20 years of age at a tertiary care centre in India over a 3 year period were reviewed. The ophthalmological examination findings, Goldmann perimetry, electrophysiological tests and magnetic resonance imaging (MRI) were reviewed. Results: The study reviewed 28 patients (44 eyes) and found a mean age of 12.6±4.9 years (2-20 years) having a follow-up record for a mean period of 6.3±4.9 months (0.3-38 months). 32.1% were females (F: M-0.47). Six patients (20.7%) had a viral prodrome and 12 (42.9%) complained of painful ocular movements. The mean baseline visual acuity (VA) was 1.80±0.6 logMAR units (Range=0.2-3.0 logMAR units) and the last best visual acuity was 0.43±0.4 log MAR units (Range=0-1.79 logMAR units). Thirty six eyes (81.8%) had a visual acuity at or below 3/60 and 40 eyes (90.9%) of 6/60 or lower of the snellen chart at the time of presentation. The mean contrast sensitivity at presentation was 1.02±0.46 (range=0-1.65). 16 pts (57.1%) had a bilateral presentation and 20 patients (71.4%) had either unilateral or bilateral papillitis. All the patients were given pulse dexamethasone (3-5 mg/kg/d) for three consecutive days followed by oral prednisolone (1-1.5 mgKg/day) for 11 days. At 1 week, 21 out of 44 eyes (47.7%) had a visual acuity ≥6/18 of the snellen chart. Three patients showed demyelination suggestive of multiple sclerosis (MS) on MRI brain and were diagnosed as probable MS. A total of 9 eyes (20.5%) of 6 patients (20.7%) had a recurrence. Those below 10 years of age presented more commonly with papillitis compared to teenagers (p value=0.01). All the parameters were similar in males and females. Conclusion: Pediatric optic neuritis patients are associated with a good visual outcome and a faster recovery. There are no gender differences in either the presentation or the visual recovery. Papillitis was more often seen in the children below 10 years of age. None of the patients developed clinically definite multiple sclerosis.

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Visual Outcome and Prognostic Factors of Optic Neuritis: A Perspective from the East

Cited by 3 publications

References 18 publications

Clinical Spectrum of Neuritis Optic Patients Receiving Intravenous Corticosteroid Treatments in Doctor Kariadi Hospital Semarang

Clinical Spectrum of Neuritis Optic Patients Receiving Intravenous Corticosteroid Treatments in Doctor Kariadi Hospital Semarang

An analytical longitudinal observational study on the association of Vitamin D insufficiency in subjects with primary (idiopathic) demyelinating optic neuritis using visual evoked potential and optical coherence tomography

Clinical Spectrum of Pediatric Optic Neuritis in Indian Children

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