Visual evoked potential as an early marker of diabetic retinopathy

Khatoon, Farisa; Bahmed, Farah; Khatoon, Nazeema

doi:10.5958/2394-2126.2016.00046.3

Cited by 6 publications

(12 citation statements)

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“…These results are comparable to the findings of Gupta et al [17] who recorded PRVEP in 100 subjects (50 patients with type 2 diabetes without DR and 50 controls), mean age of diabetics was 51.6±9.48 years and that of controls was 51.24±9.55 years, he found a statistically significant increase in mean P100 latency (P<0.0001) as compared to the controls, mean N75 and N145 latencies showed an increase in diabetics but without statistical significance. These findings are also consistent with many previous similar studies including that by Heravian et al [18], Khatoon et al [19], Daniel et al [20], Gowri V [21], and Kothari et al [22], in their studies also reported a significant prolongation when they compared the mean P100 latency in diabetics without DR and controls. The difference between all studies and ours was the mean peak time values, variability could be explained by many factors like inclusion or exclusion criteria, sample sizes, and differences in recording conditions.…”

Section: Discussionsupporting

confidence: 92%

“…There are great inter individual variations in the amplitudes of VEP compared with the peak time of responses. The VEP amplitude can be modified by attention, cranial shape, distribution of sulci of brain and size of the brain [19].…”

Section: Discussionmentioning

confidence: 99%

“…Oxidative stress, besides micro vascular abnormalities and consequences of glucose metabolism, play a great role in the pathological progress of diabetic retinopathy. That might be due to either an increase in free radical and oxidant production or reduced activity of anti-oxidative mechanisms [19].…”

Section: Discussionmentioning

confidence: 99%

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Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus

Saadoun¹,

Rajab²,

Yousef³

2020

AJBLS

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Background: Retinopathy is a severe and common complication of diabetes. The pathology seems to be characterized not only by the involvement of retinal micro vessels but also by a real neuropathy. Before the onset of micro vascular lesions, the retina of the eye undergoes subtle functional changes that are not detectable by fundus photography. Electrophysiological investigations allow a more detailed study of the visual function. These techniques are safe, repeatable, quick, and objective. Objective: To study pattern electroretinogram (PERG) and pattern reversal visual evoked potentials (PRVEP) in type 2 diabetic patients without diabetic retinopathy (DR) or with mild non-proliferative DR (mNPDR) to detect changes by comparing with those of healthy control. And to assess the correlation of the parameters with diabetes duration and the level of Glycosylated Haemoglobin A1c (HbA1c). Materials and Methods: It was a cross-sectional study, included two groups (diabetic patients and the healthy). Age range was preset at 40-65 years. For all the participants, a detailed clinical history was collected, a comprehensive ophthalmic examination and thorough blood investigations were performed, then {PRVEP (60', 15'), PERG} were recorded and (waveform, peak time, amplitude) of tests components were analyzed. Results: Mean (P100, N135) peak times of PRVEP were statistically significantly delayed in (50) eyes of type 2 diabetics without DR when compared to (36) eyes of control (p-value<0.01), abnormalities in waveforms like (double peaks, broad peak) were also observed in diabetics. There were alterations in other parameters (amplitudes of PRVEP, peak times and amplitudes of PERG) but the changes were not statistically significant. No statistically significant changes were found in (6) eyes of diabetic patients with mNPDR. No statistically significant correlation was obtained between diabetes duration or the level of HbA1c and delay of peak times or reduce amplitudes in patients. Conclusions: Electrophysiological tests are sensitive and useful investigations for the early identification of visual dysfunctions before the development of overt retinopathy in type 2 diabetics. PRVEP is more sensitive than PERG to monitor alterations and it may be sufficient to screen the patients in this stage.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus

Saadoun¹,

Rajab²,

Yousef³

2020

AJBLS

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“…11 A cross sectional study done on 100 type 2 diabetes and 100 healthy controls showed significant prolongation of P100 latency in type 2 diabetes and a significant positive correlation between duration of diabetes with P100 latency but not with amplitude of P100. 12 VEP was done on 111 subjects, aged 40-70 years of both sexes. Subjects were divided into 3 groups; patients with type 2 diabetes, patients with diabetic retinopathy and normal subjects and total number of subjects in each group was 37.…”

Section: Discussionmentioning

confidence: 99%

Visual Evoked Potentials (VEPs) in Patients with Type 2 Diabetes Mellitus

Subedi

Limbu

Maskey

et al. 2022

Kathmandu Univ. Med. J.

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Background Type 2 diabetes constitutes about 85-95% of all diabetes in developed countries, and accounts for an even higher percentage in developing countries. Diabetic retinopathy is probable the most characteristic, easily identifiable and treatable complication of diabetes, but remains an important cause of visual loss. Objective To study P100 latencies and inter ocular latency difference in diabetic group and compared it with a control group and study the correlation between P100 and inter ocular latency difference with the duration of disease in diabetic group. Method A comparative, cross sectional study was done from September 2016 to January 2018 in Neurophysiology Lab, Basic and Clinical Physiology, BP Koirala Institute of Health Sciences. The sample size was 64 and random sampling technique was used. Subjects were divided into three groups according to the duration of disease. Anthropometric and visual evoked potentials were recorded. Descriptive analysis, analysis of covariance and Post Hoc multiple comparison analyses were done using SPSS 11.5. Pearson’s correlation was applied between P100 latency and inter ocular latency difference with the duration of disease. Result On using analysis of covariance, P100 latencies were significantly prolonged in diabetic as compared to healthy controls (p < 0.001). Post Hoc multiple comparison showed significant differences in both left and right P100 latencies within diabetic groups and between diabetic groups and healthy controls. Left inter ocular latency difference showed positive correlation with the duration of disease. Conclusion P100 latencies are significantly prolonged in diabetes patients and is positively correlated with duration of disease. Visual evoked potential test can be useful for detecting retinal dysfunction before the appearance of symptoms of retinopathy.

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“…This was in accordance with previous studies of adults and children. The prolongation of the P100 latencies are indicative of structural damage to myelinated optic nerve fibres (14,15).…”

Section: Discussionmentioning

confidence: 99%

The Evaluation of Pattern-Reversal Visual Evoked Potentials in Children with Type 1 Diabetes Mellitus

et al. 2019

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Background: Asymtomatic santral nervous system disorder is frequently found in patients with diabetes. Neurophysiological tests were found to be objective and sensitive tool for detecting subclinical optic nerve and CNS disorders. Objectives: Our aim is to evaluate of the central nerve conduction changes using visual evoked potentials (VEP) and to demonstrate the effects of various risk factors on VEP parameters in children with type 1 diabetes mellitus (T1DM). Methods: Sixty children aged between 6 and 18 years and followed-up with a diagnosis of T1DM were enrolled in the study. Thirty healthy, age-matched children were enrolled as the control group. All patients and controls underwent the pattern reversal visual evoked potentials (PRVEP) test. Patients' HbA1c values, age, sex and duration of disease were evaluated from their hospital files. Results: Both right and left VEP latencies were significantly longer in the diabetic group than in the control group (P = 0.001 and P = 0.001, respectively). The mean duration of T1DM in the patient group was 5.5 years (min: 1 -max: 15). There was a positive correlation between longer VEP latency values and duration of DM, with coefficients of 0.49 for the right eye and 0.513 for the left eye (P < 0.001 and P < 0.001, respectively). Conclusions:We found that optic nerve conduction diminished significantly in children with T1DM. Visual evoked potential datas showed a significant prolongation of the latency of P-100. We recommend that all diabetic children be scanned with neurophysiological tests such as PRVEP for optic neuropathy.

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Visual evoked potential as an early marker of diabetic retinopathy

Cited by 6 publications

References 0 publications

Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus

Electroretinogram and Visual Evoked Potentials in Patients with Type ll Diabetes Mellitus

Visual Evoked Potentials (VEPs) in Patients with Type 2 Diabetes Mellitus

The Evaluation of Pattern-Reversal Visual Evoked Potentials in Children with Type 1 Diabetes Mellitus

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