Visual complaints and visual hallucinations in Parkinson's disease

Urwyler, Prabitha; Nef, Tobias; Killen, Alison; Collerton, Daniel; Thomas, Alan; Burn, David J.; McKeith, Ian G.; Mosimann, Urs Peter

doi:10.1016/j.parkreldis.2013.12.009

Cited by 84 publications

(109 citation statements)

References 24 publications

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“…Only controlled cross-sectional NEVHI studies with ED, PD, PDD, and DLB samples using similar methodology were included in this study. Three (3,4,8) of them had two sample groups (patients, controls), while the other two had three sample groups (controls, ED, DLB;(2) controls, PD, PDD(5)).…”

Section: Study Selection and Data Collectionmentioning

confidence: 99%

“…The control groups which included friends/relatives (2,8) or spouses of patients, (2,3,5,8) volunteers recruited via advertisement in the Newcastle Elders magazine(4) and in a local church (3,4) and healthy controls from the research database held at the Institute for Ageing, Newcastle University (3,5) comprise the comparison group in this study. Diagnostic criteria were met using the revised International Consensus Guidelines from the third report of the DLB consortium for DLB, the Movement Disorder Committee, United Kingdom.…”

Section: Study Selection and Data Collectionmentioning

confidence: 99%

“…The aim of the present study was to compare the phenomenology and characteristics of VH in ED, PD, LBD patients using the NEVHI(3) interview based on patient information. (23) We hypothesized that the phenomenology and characteristics of VH would be different across diseases. We further explored the effects of gender on hallucinatory content.…”

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confidence: 99%

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Visual Hallucinations in Eye Disease and Lewy Body Disease

Urwyler

Nef

Müri

et al. 2016

The American Journal of Geriatric Psychiatry

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Objective: Visual hallucinations (VH) most commonly occur in eye disease (ED), Parkinson's disease (PD), and Lewy body dementia (LBD). The phenomenology of VH is likely to carry important information about the brain areas within the visual system generating them. Methods: Data from five controlled cross-sectional VH studies (164 controls, 135 ED, 156 PD, 79 (PDD 48 + DLB 31) LBD) were combined and analysed. The prevalence, phenomenology, frequency, duration, and contents of VH were compared across diseases and gender. Results: Simple VH were most common in ED patients (ED 65% METHODS Study Selection and Data CollectionThere have been several studies(2-5, 8, 24) using NEVHI(3) since its original publication in 2008. Only controlled cross-sectional NEVHI studies with ED, PD, PDD, and DLB samples using similar methodology were included in this study. Three(3, 4, 8) of them had two sample groups (patients, controls), while the other two had three sample groups (controls, ED, DLB;(2) controls, PD, PDD (5) Committee, United Kingdom. All procedures related to the study were explained to the participants and a written informed consent was obtained prior to participation. All data were merged into a single database including 164 individuals in the comparison group and 383 patients (135 ED, 156 PD, 48 PDD, 31 DLB, 13 with combination of ED/PD/PDD/DLB). The latter 13 patients were excluded from further analysis. A sub-analysis of VH phenomenology did not reveal any differences between DLB and PDD patients, which were subsequently considered as one LBD group. PD and LBD patients were only included if they had no visual field defects on neurological examination. AssessmentsAn interview was used to gather demographic data in all studies. Best near visual acuity was examined 6 members/children), "body parts", "animals/insects", "machines", and "letters/numbers/musical notes".(7, 13, 15) Prevalence, phenomenology, frequency, duration and severity of VH were compared between the (i) comparison group and patients and (ii) different patient groups (ED, PD, LBD). The phenomenology of Complex VH was also compared between gender. Statistical analysisStatistical analysis was undertaken using the Statistical Package for Social Sciences (SPSS Version 20).Normal distribution of data was examined using the Shapiro-Wilk test. Means and standard deviations (SD) were calculated. Data were analysed using parametric tests (one-way analysis of variance (ANOVA)). Multiple comparisons were assessed with Post-hoc Bonferroni tests. Frequencies were compared using the chi-square (χ 2 ) test and Fisher's exact test when expected frequency in either group was < 5. The effect of gender, disease and interaction of gender × disease on contents of complex VH was tested using a two-way ANOVA (Effect sizes are reported using partial η 2 ), whilst logistic regression was used to ascertain whether the VH phenomenology could significantly predict the disease. The homogeneity of variance of the interaction model was tested using Levene's test, while go...

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Section: Study Selection and Data Collectionmentioning

confidence: 99%

Section: Study Selection and Data Collectionmentioning

confidence: 99%

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Visual Hallucinations in Eye Disease and Lewy Body Disease

Urwyler

Nef

Müri

et al. 2016

The American Journal of Geriatric Psychiatry

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“…17,[44][45][46] These broad reported ranges highlight the difficulty of carrying out cross-study comparisons. Common variations in study design identified from a targeted literature review (unpublished findings) include the criteria for patient selection, the definition of PDP, the symptoms of psychosis that were of interest to study investigators, differences in the methodology used to assess symptoms, and the timeframe over which symptoms were observed.…”

Section: Disruptiveness and Comorbidity Ratesmentioning

confidence: 99%

Parkinson’s Disease Psychosis – Prevalence Patterns Across the EU-5

Cook¹,

Suresh²,

Lou³

et al. 2017

European Neurological Review

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Parkinson's disease psychosis (PDP) is a clinical condition that affects patients diagnosed with Parkinson's disease (PD) and has a spectrum of neuropsychiatric symptoms distinct from the hallmark motor symptoms. Although prior studies have reported on the prevalence of PDP in select European nations, variations in study design complicate study-to-study comparisons. In this study, we surveyed 1,667 medical practitioners across France, Germany, Italy, Spain, and the UK (collectively, the EU-5) to estimate the prevalence of PDP or symptoms of psychosis among patients with PD. Analysis of the survey data suggest approximately 29% of the general PD population in the EU-5 exhibit signs of PDP. Among the PD population, country-specific rates of PDP are estimated at 30% in France, 27% in Germany, 34% in Italy, 30% in Spain and 21% in the UK. These rates appear in line with those reported in prior country-specific studies. Results from the subset of 437 neurologists who proceeded to take the full survey suggest the symptoms of PDP are disruptive to patients or their respective caregivers in approximately 53% of cases. These results provide a resource that enables cross-country comparison of PDP rates across these major European nations.

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“…Vision Changes and Hallucinations are also common in PD patients, which have been reported to deduct the quality and pace of life [112]. Blurred vision and dry eyes are the initial response towards alteration of vision in PD [113].…”

Section: Vision Changes and Hallucinationsmentioning

confidence: 99%

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Choudhury¹,

Rao²,

R³

et al. 2017

Neuropsychiatry

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While most of the clinical concerns for Parkinson's disease (PD) are limited to the cardinal motor abnormalities, non-motor features like cognitive and psychological anomalies are also acquired ample of importance in last few decades. Progressive research has showcased several obvious incidences of cognitive and psychological anomalies in the pathophysiology of PD. It has been reported that, almost 30% PD sufferers show different degree of cognitive impairment but lack of awareness or negligence makes it difficult to diagnose it, at the initial stage of the disease. As a result, cognitive and psychological impairments continue to increases progressively and deteriorate the quality of life of the patient. It is presumable that, early detection of PD can be achieved by the identification of specific set of cognitive and psychological anomalies and the similar scope might open up new avenue in the non-invasive diagnosis of PD. In the present review, we have accumulated all the timely documentation on cognitive and psychological anomalies in PD and highlighted most of the non-motor features with rational justification for the relevance of their study in the early diagnosis of PD.

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Visual complaints and visual hallucinations in Parkinson's disease

Cited by 84 publications

References 24 publications

Visual Hallucinations in Eye Disease and Lewy Body Disease

Visual Hallucinations in Eye Disease and Lewy Body Disease

Parkinson’s Disease Psychosis – Prevalence Patterns Across the EU-5

Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

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