Cognitive and Psychological Anomalies in Parkinsons Disease: An Insight into Non-Motor Characteristic Features

Choudhury, Amarendranath; Rao, D Manikyala; R, Jagadeesh Varma; Banerjee, Tuhin Subhra; R, Arun Kumar; Adapa, Dattatreya

doi:10.4172/neuropsychiatry.1000317

Cited by 3 publications

(3 citation statements)

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“…All sectors of the textile processing industry are striving to increase their sustainability [13] and the wool sector is no exception [14][15][16][17][18]. Research into the scouring of raw wool (wool scouring) has included investigations into the effects of ultrasound [19], complexing agents [20], increasing the value of recovered wool grease [21], the colour of scoured wool and many other aspects [22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

The application of biosurfactants for scouring wool

Leighs

McNeil

Ranford

2018

Coloration Technology

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The first investigation of the use of biosurfactants for the scouring of raw wool is reported. A saponin, and a recently developed surface active oat extract, were evaluated at the laboratory scale using a first-to-bereported benchtop scouring system with simulated flowback. The levels of contaminants remaining on the wool after bioscouring, along with the wool colour, were compared with those of wool that had been laboratory-scoured with a surfactant used in the commercial scouring of raw wool, namely a synthetic nine molar poly(oxyethylene)nonylphenyl (NPEO). Both biosurfactants can be extracted from land-based renewable crops. The saponin proved to be effective, producing low levels of residual contaminants on the wool, and colours that were not statistically different to those of wool scoured with NPEO. The oat extract was considerably less effective than the saponin, both in terms of colour and residual contaminant level. This study demonstrated the significant potential of biosurfactants in the scouring of the global greasy wool clip, which now comprises two billion kg per annum.

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Section: Introductionmentioning

confidence: 99%

The application of biosurfactants for scouring wool

Leighs

McNeil

Ranford

2018

Coloration Technology

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“…Study done by Chaudhary KR et al showed that sleep disturbances, cognitive impairment and bowel/bladder disturbances were frequent in PD. 2 Shulman and Colleagues reported that NMS complex is frequently unrecognised and/or neglected by healthcare professionals. 3 Another International survey showed that 62.5% of NMS in PD remain unknown to healthcare professionals because patients are either too embarrassed to reveal them or are unaware that these symptoms are linked to PD.…”

Section: Discussionmentioning

confidence: 99%

Study of non-motor Symptoms in Parkinsons disease and its impact on their quality of life

Mamlekar,

Gomes,

Ferreira

2023

IJN

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Parkinson's disease (PD) is a neurodegenerative disorder characterised by the degeneration of dopaminergic nigrostriatal pathway. Its incidence ranges from 1 to 2 per 1000 in general population. Its a complex disorder characterised by motor and non-motor symptoms that can impair the quality of life (QoL). In the presence of effective symptomatic therapies for the motor symptoms of Parkinson's disease, the non-motor symptoms have become the major prognostic factors determining the overall disease burden and everyday function in Parkinson’s disease patients. Our study aimed at assessing the frequency and proportion of non-motor symptoms in PD patients and to assess their impact on QoL. A total of 88 PD patients visiting the outpatient department of Neurology at Goa Medical College were assessed for various non-motor symptoms using a semi – structured questionnaire and appropriate scales. Quality of life was assessed using PDQ-39 questionnaire. Patients satisfying the United Kingdom Parkinson’s Disease brain bank criteria for idiopathic Parkinson’s diseases were included in the study Single centre, Cross-sectional study. Mean age of study population was 68 years and mean duration of the disease was 5yrs. Attention and memory were the most frequently reported domain in the study population (52 patients, 59.75 percent) followed by mood and cognition (46 patients, 52.74 percent). The least reported symptom was perceptual problems including delusions and hallucinations (11.74%) and miscellaneous domain (10.93 percent) which included pain, olfactory dysfunction, increased perspiration and weight fluctuations. The mean UPDRS (part 3) score was found to be 33.24± 17.37 with values ranging from 3.57 (mild motor impairment) to 44.64 (severe motor impairment).The QoL assessment showed that impairment of Mobility had a major impact on QoL followed by activities of daily living and emotional well-being. Correlation between Non-motor symptoms and PDQ-39 revealed that mood, cognition and perceptual problems had an adverse outcome on their emotional well-being and deficit in attention and memory had significant outcomes on communication. This study highlights the fact that non-motor symptoms in PD significantly impair quality of life and we should incorporate screening tools to evaluate patients with autonomic, sensory or mood disturbances so that they are detected at the earliest as most of them precede motor symptoms by decades.

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“…Moreover, current drug therapy aiming to improve dopaminergic signaling did not completely restore motor functions & is associated with other non-motor symptoms such as dyskinesia, anxiety, depression, fatigue, sleep disturbance, or sensory symptoms [46]. In Parkinson's disease, when the level of dopamine decreases, there is also the decrease in another neurotransmitter, acetylcholine since the motor function of the striatum is dependent on the equilibrium between dopamine and acetylcholine.…”

Section: Non-dopaminergic Signalingmentioning

confidence: 99%