Viscosimetric behaviour of hyaluronic acid in different aqueous solutions

García-Abuín, Alicia; Gómez‐Díaz, Diego; Navaza, José M.; Regueiro, Leticia; Vidal, Isabel

doi:10.1016/j.carbpol.2011.02.028

Cited by 37 publications

(25 citation statements)

References 14 publications

(13 reference statements)

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“…In other words, the apparent viscosity for pseudoplastic fluids (hyaluronic acid), defined as the slope of the curve in Figure 2, decreases when the shear rate increases [42]. For Newtonian fluids, it is constant.…”

Section: Theorymentioning

confidence: 99%

Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases

Ahumada

González

Sandoval

et al. 2016

Sensors

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The main objective of this article is to demonstrate through experimental means the capacity of the quartz crystal resonator (QCR) to characterize biological samples of aqueous dilutions of hyaluronic acid according to their viscosity and how this capacity may be useful in the potential diagnosis of arthritic diseases. The synovial fluid is viscous due to the presence of hyaluronic acid, synthesized by synovial lining cells (type B), and secreted into the synovial fluid thus making the fluid viscous. In consequence, aqueous dilutions of hyaluronic acid may be used as samples to emulate the synovial fluid. Due to the viscoelastic and pseudo-plastic behavior of hyaluronic acid, it is necessary to use the Rouse model in order to obtain viscosity values comparable with viscometer measures. A Fungilab viscometer (rheometer) was used to obtain reference measures of the viscosity in each sample in order to compare them with the QCR prototype measures.

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Section: Theorymentioning

confidence: 99%

Evaluation of Hyaluronic Acid Dilutions at Different Concentrations Using a Quartz Crystal Resonator (QCR) for the Potential Diagnosis of Arthritic Diseases

Ahumada

González

Sandoval

et al. 2016

Sensors

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“…The presence of HA in an aqueous solution shows a complex rheological behavior, including this system into the pseudoplastic fluids，which is very important for its applications. The rheological characterization of HA aqueous solutions has been carried out byGarcia, determining the value of the intrinsic viscosity and the average molecular weight. Both the increase of temperature and the presence of an electrolyte produce an important decrease in the viscosity magnitude, as well as an approximation to the Newtonian behavior related to its rheology.…”

Section: Demineralized Bone Matrix Carriersmentioning

confidence: 99%

Demineralized Bone Matrix Carriers and their Clinical Applications: An Overview

Zhang

Yang

et al. 2019

Orthopaedic Surgery

105

102

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Reconstruction of massive bone defects is challenging for orthopaedic clinicians, especially in cases of severe trauma and resection of tumors in various locales. Autologous iliac crest bone graft (ICBG) is the “gold standard” for bone grafting. However, the limited availability and complications at donor sites resulted in seeking other options like allografts and bone graft substitutes. Demineralized bone matrix (DBM) is a form of allograft using acidic solution to remove mineral components, while leaving much of the proteinaceous components native to bone, with small amounts of calcium‐based solids, inorganic phosphates, and some trace cell debris. It is an osteoconductive and osteoinductive biomaterial and is approved as a medical device for use in bone defects and spinal fusion. To pack consistently into the defect sites and stay firmly in the filling parts, DBM products have various forms combined with biocompatible viscous carriers, including sponges, strips, injectable putty, paste, and paste infused with chips. The present review aims to summarize the properties of various kind of viscous carriers and their clinical use combined with DBM in commercially available products. Given DBM'mercially available products. Given DBM;s long clinical track record and commercial accessibility in standard forms, opportunities to further develop and validate DBM as a versatile bone biomaterial in orthopaedic repair and regenerative medicine contexts are attractive.

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“…The action of such forces can result in irreversible changes in the tertiary and quaternary structures of macromolecular systems [4,5], thereby determining the physicochemical properties of individual chains and the system as a whole [5][6][7][8]. These changes can include the organisation of macromolecular segments and coils, their mean size [9][10][11], rigidity, ability to occupy a phase boundary [12][13][14], viscosity [3,[15][16][17][18], temperature of phase transitions, etc. The effects of the preceding thermal exposure (thermal history) [6] or pH and ionic strength fluctuations in a solution [12,[19][20][21][22][23] are also appreciable.…”

Section: Introductionmentioning

confidence: 98%