Visceral Obesity in Predicting Oncologic Outcomes of Localized Renal Cell Carcinoma

Park, Yong Hyun; Lee, Jeong Keun; Kim, Kwang Mo; Kook, Ha Rim; Lee, Hansol; Kim, Ki Bum; Lee, Sangchul; Byun, Seok‐Soo

doi:10.1016/j.juro.2014.03.107

Cited by 55 publications

(49 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…9 Although one recent study showed a U-shaped association between VAT% (VAT/total adipose tissue × 100) and the risk of disease recurrence among patients with localized renal cell carcinoma, they did not include patients with advanced RCC, and did not analyze the effect of visceral obesity on cancer-specific mortality. 21 Another study also showed that high VFA was associated with a better oncological outcome in male RCC patients. 7 However, whether visceral obesity quantitatively measured by VFA and/or V/S at treatment initiation predicts outcomes in patients with advanced RCC has not been well investigated.…”

Section: Discussionmentioning

confidence: 96%

Prognostic significance of visceral obesity in patients with advanced renal cell carcinoma undergoing nephrectomy

et al. 2015

View full text Add to dashboard Cite

Results: High visceral fat area (greater than 50 percentiles in each sex) was associated with longer cancer-specific survival (P = 0.01) or overall survival (P = 0.03), whereas visceral fat area/subcutaneous fat area ratio showed no influence on survival outcomes. By multivariate analysis adjusted with clinicopathological variables, low visceral fat area was an independent predictor of cancer-specific death and overall death (cancer-specific survival P = 0.004, hazard ratio = 2.19; overall survival P = 0.003, hazard ratio = 2.22), as well as old age (P = 0.01), radical nephrectomy (P = 0.002), high tumor grade (P = 0.01) and the presence of a sarcomatoid component (P < 0.001) in the subgroup analysis of advanced renal cell carcinoma. Conclusion: High visceral fat area might represent a predictor of better prognosis in patients with advanced renal cell carcinomas undergoing nephrectomy.

show abstract

Section: Discussionmentioning

confidence: 96%

Prognostic significance of visceral obesity in patients with advanced renal cell carcinoma undergoing nephrectomy

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Visceral adipose tissue percent (VAT%) was calculated using the formula: VAT% = [VFA/VFA + SQF] · 100%. 5 The utilization of a VFA ratio allowed for further comparison of fat compartments. Renal function was calculated using the Modification of Diet in Renal Disease (MDRD) equation, and we defined chronic kidney disease (CKD) stage III as a glomerular filtration rate <60.…”

Section: Methodsmentioning

confidence: 99%

The Relationship Between Visceral Obesity and the Clinicopathologic Features of Patients with Small Renal Masses

Keehn

Srivastava

Maiman

et al. 2015

Journal of Endourology

View full text Add to dashboard Cite

VFA may be linked to the pathophysiology of renal function in patients evaluated for renal masses. Additionally, VFA may be associated with worsening tumor grades in patients with small-volume RCC. Interestingly, SQF did not play such a role. This small study proposes an interesting physiologic link between VFA and the biology of both kidney function and tumor histology. Larger studies are needed to corroborate our findings.

show abstract

“…1,2 Obesity is associated with multiple medical conditions, including cardiovascular disease, diabetes, several types of malignancy, and renal disease. [3][4][5][6] Despite com munity efforts both domestically and abroad to counsel patients regarding weight management through exercise and healthy eating, the rates of obesity continue to increase. This is of particular concern to physicians who treat obese patients, as many have renal impairment as a direct consequence of metabolic complications from obesity.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Dru

Fuchs²

2017

Exp Clin Transplant

View full text Add to dashboard Cite

Objectives: As the demand for kidney transplant allografts has increased, many centers are expanding the upper limit of acceptable body mass index for kidney donors. However, obesity is a risk factor for developing renal disease. Our goal was to quantify body mass index trends in donor nephrectomy patients and to institute nutrition counseling to promote sustainable weight loss to reduce the risk of metabolic syndrome-derived renal dysfunction. Materials and Methods: Ninety patients who underwent donor nephrectomy between 2007 and 2012consented to having height and weight data collected at multiple time points. After data collection, each patient underwent a standardized nutrition counseling session. One year later, body mass index was reassessed. Results: Preoperatively, 52% of the patients were overweight or obese. The percentage of overweight and obese patients remained stable for 2 years after surgery. However, at 3, 4, and 5 years after surgery, these rates increased to 59%, 69%, and 91%. Each patient was counseled about obesity-related comorbidities and provided information about lifestyle modification. One year later, 94% of previously overweight patients and 82% of previously obese patients had a decrease in mean body mass index from 27.2 ± 4.0 kg/m 2 to 25.1 ± 3.6 kg/m 2 . Conclusions: Living-donor nephrectomy patients are at risk of developing obesity, similar to the adult population. Nutrition counseling may be beneficial to help normalize body mass index in patients who have become overweight or obese to potentially prevent obesity-related comorbidities. All patients were evaluated by a nutrition specialist after surgery to review our donor nephrectomy nutrition brochure. Body mass index monitoring and primary care followup appear to be appropriate surveillance methods.

show abstract

Visceral Obesity in Predicting Oncologic Outcomes of Localized Renal Cell Carcinoma

Abstract: Relative visceral obesity as assessed by VAT% was associated with clinicopathological characteristics of localized renal cell carcinoma. A U-shaped association between VAT% quartiles and risk of disease recurrence was observed among patients with localized renal cell carcinoma.

Cited by 55 publications

References 29 publications

Prognostic significance of visceral obesity in patients with advanced renal cell carcinoma undergoing nephrectomy

Prognostic significance of visceral obesity in patients with advanced renal cell carcinoma undergoing nephrectomy

The Relationship Between Visceral Obesity and the Clinicopathologic Features of Patients with Small Renal Masses

Untitled

Contact Info

Product

Resources

About