The Relationship Between Visceral Obesity and the Clinicopathologic Features of Patients with Small Renal Masses

Abstract

VFA may be linked to the pathophysiology of renal function in patients evaluated for renal masses. Additionally, VFA may be associated with worsening tumor grades in patients with small-volume RCC. Interestingly, SQF did not play such a role. This small study proposes an interesting physiologic link between VFA and the biology of both kidney function and tumor histology. Larger studies are needed to corroborate our findings.

Distinguishing malignant and benign renal masses with composite models and nomograms: A systematic review and meta‐analysis of clinically localized renal masses suspicious for malignancy

“…The remainder of the studies were single‐center analyses. Ten studies were completed in Asia, 9 were completed in North America, and 1 was completed in Europe . The median study start year was 2000 (1988‐2010).…”

“…Notably, 19 of the 20 studies incorporated a component of imaging, and 2 studies used imaging alone. Ten studies were designed to predict malignant pathology, whereas the remaining 10 were designed to predict benign pathology . The strength of evidence was considered low for preoperative composite models as a whole because of differences in patient populations and discordant variables included in the models.…”

“…Fifteen studies included age as a predictor of pathological outcome . Five of the 15 studies (33.3%) found age to be predictive of malignant or benign disease; 10 (66.7%) found age not to be predictive …”

“…Sixteen studies included sex as a predictor of pathological outcomes . Fourteen of the 16 studies (88%) found sex to be predictive of malignant or benign disease; 2 found sex not to be predictive . The 2 studies that found sex not to be predictive of histology were not included in a meta‐analysis because one study did not report a relative risk for malignancy based on sex, and the other study did not provide CIs for the multivariate analysis but found that 9 of 95 men (9.5%) and 11 of 49 women (22.4%) had benign pathologies (multivariate odds ratio, 2.62; P = .079).…”

“…Five studies included BMI as a potential predictor of pathological diagnosis, but because of differences in study methodology, the data could not be sufficiently combined for a meta‐analysis of BMI. Only 1 study found BMI to be an independent predictor of malignancy in the overall cohort .…”