Visceral Larva Migrans: Immunoglobulins, Precipitating Antibodies and Detection of IgG and IgM Antibodies against Ascaris Antigen *

Patterson, Roy; Huntley, Carolyn C.; Roberts, Mary; Irons, John S.

doi:10.4269/ajtmh.1975.24.465

Cited by 11 publications

(2 citation statements)

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“…14 It is believed that the precipitating antibodies may be the cause of renal disorders due to antigen± antibody complex and disease of the Arthus type. 15 In summary, we present a case of NS associated with T. canis infection. The relationship between T. canis and NS should be explored in children, particularly in endemic regions.…”

Section: Discussionmentioning

confidence: 86%

Nephrotic syndrome associated withToxocara canisinfection

Shetty

Avilés

1999

Annals of Tropical Paediatrics

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This case report describes nephrotic syndrome in a 7-year-old boy coincident with Toxocara canis infection. This rare association was confirmed by elevated Toxocara-specific IgM titres. Treatment with corticosteroids resulted in remission of renal symptoms as well as abatement of the T. canis infection. The relationship between T. canis infection and glomerular disease is still unclear; nephrotic syndrome may be another manifestation of T. canis infection.

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Section: Discussionmentioning

confidence: 86%

Nephrotic syndrome associated withToxocara canisinfection

Shetty

Avilés

1999

Annals of Tropical Paediatrics

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“…Additionally, variants of the indirect ELISA principle, such as reverse enzyme immunoassay (REIA), sandwich ELISA, and multiple-dot ELISA, have also been explored [ 28 – 30 ]. Direct and indirect fluorescent antibody tests (FAT) [ 31 , 32 ], radioimmunoassays (RIA) [ 33 , 34 ], complement fixation tests [ 35 , 36 ], and double immunodiffusion tests [ 30 , 34 , 36 , 37 ], were employed until 2003, after which ELISA and western blot became the predominant techniques together with new technologies that appeared on the scene ( S4 Info ). Among these new technologies, the multiplex bead assay [ 38 ], peptide microarray immunoassays [ 39 , 40 ] and quantitative suspension array technology (qSAT) assays [ 41 , 42 ] represent examples of multiplex assays.…”

Section: Resultsmentioning

confidence: 99%

Serological diagnosis of soil-transmitted helminth (Ascaris, Trichuris and hookworm) infections: A scoping review

Roose,

Vande Velde,

Vlaminck

et al. 2024

PLoS Negl Trop Dis

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Background The World Health Organization emphasizes the importance of integrated monitoring and evaluation in neglected tropical disease (NTD) control programs. Serological assays offer a potential solution for integrated diagnosis of NTDs, particularly for those requiring mass drug administration (MDA) as primary control and elimination strategy. This scoping review aims (i) to provide an overview of assays using serum or plasma to detect infections with soil-transmitted helminths (STHs) in both humans and animals, (ii) to examine the methodologies used in this research field and (iii) to discuss advancements in serological diagnosis of STHs to guide prevention and control programs in veterinary and human medicine. Methodology We conducted a systematic search in the Ovid MEDLINE, Embase and Cochrane Library databases, supplemented by a Google search using predefined keywords to identify commercially available serological assays. Additionally, we performed a patent search through Espacenet. Principal findings We identified 85 relevant literature records spanning over 50 years, with a notable increased interest in serological assay development in recent years. Most of the research efforts concentrated on diagnosing Ascaris infections in both humans and pigs, primarily using ELISA and western blot technologies. Almost all records targeted antibodies as analytes, employing proteins and peptides as analyte detection agents. Approximately 60% of sample sets described pertained to human samples. No commercially available tests for Trichuris or hookworms were identified, while for Ascaris, there are at least seven different ELISAs on the market. Conclusions While a substantial number of assays are employed in epidemiological research, the current state of serological diagnosis for guiding STH prevention and control programs is limited. Only two assays designed for pigs are used to inform efficient deworming practices in pig populations. Regarding human diagnosis, none of the existing assays has undergone extensive large-scale validation or integration into routine diagnostics for MDA programs.

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Visceral Larva Migrans

Zinkham¹

1978

Am J Dis Child

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Visceral larva migrans is a disease in which the larvae of animal parasites invade human tissues but do not complete their life cycles. The most frequent cause of this illness in children is the dog roundworm, Toxocara canis. A review of the literature, as well as our clinical experience, indicates that there are two forms of clinical expression: one, visceral, and the other, ocular. In general the clinical and laboratory abnormalities (hepatomegaly, recurrent pneumonia, eosinophilia, and hyperglobulinemia) usually associated with visceral disease are absent in children with ocular abnormalities. Conversely, there is a general lack of eye complications in patients with systemic disease. Reasons for these variations in clinical expression are unknown, but immune responses of the host and the antigenic composition of the parasite may be contributing factors.

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Visceral Larva Migrans: Immunoglobulins, Precipitating Antibodies and Detection of IgG and IgM Antibodies against Ascaris Antigen *

Cited by 11 publications

References 0 publications

Nephrotic syndrome associated withToxocara canisinfection

Nephrotic syndrome associated withToxocara canisinfection

Serological diagnosis of soil-transmitted helminth (Ascaris, Trichuris and hookworm) infections: A scoping review

Visceral Larva Migrans

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