Visceral Fatness and Insulin Sensitivity in Women With a Previous History of Gestational Diabetes Mellitus

Lim, Soo; Choi, Sung Hee; Park, Young Joo; Park, Kyong Soo; Lee, Hong Kyu; Jang, Hak Chul; Cho, Nam H.; Metzger, Boyd E.

doi:10.2337/dc06-1405

Cited by 42 publications

(26 citation statements)

References 37 publications

(53 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Changes in regional fat distribution and increased intra-abdominal visceral fat accumulation have been reported during normal pregnancy (22). Post-partum visceral fat was found to be greater in patients with previous GDM who also had current impaired glucose tolerance (23). However, to the best of our knowledge, there is not enough evidence about changes in visceral fat composition in pregnant women with GDM.…”

Section: Discussionmentioning

confidence: 94%

Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester

Aktürk

Altınova

Mert

et al. 2008

J Endocrinol Invest

View full text Add to dashboard Cite

ABSTRACT. Our aim is to investigate visfatin concentration and its relationship to glycated hemoglobin (HbA 1c ), insulin resistance, lipid parameters, and neonatal birth weight in women with gestational diabetes mellitus (GDM). In our study group, there were 47 women with GDM and 31 women with normal glucose tolerance (NGT) between 33-39 weeks of gestation. Plasma visfatin levels were significantly decreased in pregnant women with GDM compared to those with NGT (p=0.001). Homeostasis model assessmentinsulin resistance (HOMA-IR) levels were higher in the GDM group than in the NGT group (p=0.006). In all subjects, plasma visfatin levels were negatively correlated with HOMA-IR, post-prandial blood glucose, triglycerides, and VLDL cholesterol (p<0.05). We did not observe any statistically significant correlation between the plasma visfatin levels and the selected parameters in the GDM group, but in the NGT group plasma visfatin levels were negatively correlated with HOMA-IR (r=-0.36, p=0.04). There was no correlation between visfatin concentrations and fetal birth weight in either group (p>0.05). By regression analysis, having GDM was found to be the only significant determinant (t=3.5, p=0.001) of visfatin concentration (R=0.39, r 2 =0.15). We conclude that women with GDM have significantly decreased visfatin concentrations in the third trimester. Future studies are required to establish the exact role of visfatin in the pathogenesis of GDM. (J. Endocrinol. Invest. 31: 610-613, 2008)

show abstract

Section: Discussionmentioning

confidence: 94%

Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester

Aktürk

Altınova

Mert

et al. 2008

J Endocrinol Invest

View full text Add to dashboard Cite

show abstract

“…During pregnancy, women with GDM display metabolic abnormalities similar to those of people with type 2 diabetes (T2D), such as insulin resistance and reduced pancreatic b-cell compensation for that resistance (2). GDM most often resolves at delivery but insulin resistance and insulin secretion defects remain common in the post partum period (3,4,5).…”

Section: Introductionmentioning

confidence: 99%

Relationship between lactation duration and insulin and glucose response among women with prior gestational diabetes

Chouinard-Castonguay

Weisnagel

Tchernof

et al. 2013

European Journal of Endocrinology

View full text Add to dashboard Cite

Background: Few studies have investigated whether favorable effects of lactation persist after weaning and protect women with prior gestational diabetes mellitus (GDM) against later development of insulin resistance and insulin secretion defects. Objective: To investigate the impact of lactation duration on insulin and glucose response among women with prior GDM. Design/methods: The study group comprised 144 women with a history of GDM between 2003 and 2010. Plasma insulin and glucose concentrations were obtained from a 75 g oral glucose tolerance test (OGTT). Total lactation duration (exclusive breastfeeding and breast and bottle-feeding) for all infants was self-reported in months. Results: Mean age was 36.5G5.0 years. Time between delivery and metabolic testing was 4.0G1.9 years. Women breastfed for an average of 13.9G16.8 months. Most women (80.6%) reported a history of lactation. Women who lactated had higher homeostasis model assessment for insulin sensitivity (HOMA-IS) and Matsuda indices and lower fasting and 2-h post-OGTT insulin concentrations as well as area under the curve (AUC) for insulin (P%0.01 for all). Compared with women who lactated for !10 months, women who lactated for R10 months had improved insulin sensitivity-secretion index, higher HOMA-IS and Matsuda indices, lower fasting and 2-h post-OGTT insulin concentrations as well as AUC for insulin, and lower incidence of impaired glucose intolerance (P%0.05 for all). In multiple linear regression analyses, lactation duration emerged as an independent predictor of fasting insulin concentrations (bZK0.02) and insulin sensitivity indices (bZ0.02) (P%0.05 for all). Conclusions: These results suggest that longer duration of lactation is associated with improved insulin and glucose response among women with prior GDM.

show abstract

“…Visceral fat has been shown to contribute to the development of impaired glucose metabolism in women with history of GDM (Lim et al, 2007). Markedly elevated expression of leptin in visceral adipose depot of women with GDM may thus play a role in the development of endocrine dysfunction of visceral fat and later on also in the development of GDM.…”

mentioning

confidence: 99%

Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus

Kleiblová

Dostálová

Bartlova

et al. 2010

Molecular and Cellular Endocrinology

View full text Add to dashboard Cite

To cite this version:P. Kleiblova, I. Dostalova, M. Bartlova, Z. Lacinova, I. Ticha, et al.. Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus. Molecular and Cellular Endocrinology, Elsevier, 2009, 314 (1) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.Page 1 of 36A c c e p t e d M a n u s c r i p t A c c e p t e d M a n u s c r i p t 2 SUMMARYThe purpose of this study was to assess the expression profile of genes with potential role in the development of insulin resistance (adipokines, cytokines/chemokines, estrogen receptors) in subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT) and placenta of pregnant women with gestational diabetes mellitus (GDM) and age-matched women with physiological pregnancy at the time of Caesarean section. qRT-PCR was used for expression analysis of the studied genes. Leptin gene expression in VAT of GDM group was significantly higher relative to control group. Gene expressions of interleukin-6 and interleukin-8 were significantly increased, whereas the expressions of genes for estrogen receptors α and β were significantly reduced in SAT of GDM group relative to controls, respectively. We found no significant differences in the expression of any genes of interest (LEP, RETN, ADIPOR1, ADIPOR2, CD68, ERα, ERβ) in placentas of women with GDM relative to controls. We conclude that increased expression of leptin in visceral adipose depot together with increased expressions of proinflammatory cytokines and reduced expressions of estrogen receptors in subcutaneous fat may play a role in the etiopathogenesis of GDM.

show abstract

Visceral Fatness and Insulin Sensitivity in Women With a Previous History of Gestational Diabetes Mellitus

Cited by 42 publications

References 37 publications

Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester

Visfatin concentration is decreased in women with gestational diabetes mellitus in the third trimester

Relationship between lactation duration and insulin and glucose response among women with prior gestational diabetes

Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus

Contact Info

Product

Resources

About