Virucidal efficacy of a disinfectant solution composed of citric acid, malic acid and phosphoric acid against avian influenza virus

Chae, Won Seok; Cha, Chun-Nam; Yoo, Chang-Yeul; Kim, Suk; Lee, Hu-Jang

doi:10.13041/jpvm.2018.42.1.16

Cited by 10 publications

(10 citation statements)

References 15 publications

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“…g ., alcohols) or surfactants that achieve deactivation through viral structural perturbation . A common class of molecular virucides are quaternary ammonium compounds (QACs), which are believed to act by disrupting the phospholipid membrane of enveloped viruses. − Some viruses are acid sensitive and can be deactivated by agents that control pH outside of their compatible zone, such as citric acid, malic acid, phosphoric acid, or cyanuric acid, and are often combined with other virucidal organic compounds to achieve synergistic effects.…”

Section: Resultsmentioning

confidence: 99%

Controlled Release of Molecular Intercalants from Two-Dimensional Nanosheet Films

et al. 2021

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Solution co-deposition of two-dimensional (2D) nanosheets with chemical solutes yields nanosheet–molecular heterostructures. A feature of these macroscopic layered hybrids is their ability to release the intercalated molecular agent to express chemical functionality on their surfaces or in their near surroundings. Systematic design methods are needed to control this molecular release to match the demand for rate and lifetime in specific applications. We hypothesize that release kinetics are controlled by transport processes within the layered solids, which primarily involve confined molecular diffusion through nanochannels formed by intersheet van der Waals gaps. Here a variety of graphene oxide (GO)/molecular hybrids are fabricated and subject to transient experiments to characterize release kinetics, locations, and mechanisms. The measured release rate profiles can be successfully described by a numerical model of internal transport processes, and the results used to extract effective Z-directional diffusion coefficients for various film types. The diffusion coefficients are found to be 8 orders of magnitude lower than those in free solution due to nanochannel confinement and serpentine path effects, and this retardation underlies the ability of 2D materials to control and extend release over useful time scales. In-plane texturing of the heterostructured films by compressive wrinkling or crumpling is shown to be a useful design tool to control the release rate for a given film type and molecular intercalant. The potential of this approach is demonstrated through case studies on the controlled release of chemical virucidal agents.

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Section: Resultsmentioning

confidence: 99%

Controlled Release of Molecular Intercalants from Two-Dimensional Nanosheet Films

et al. 2021

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“…In addition, aqueous solutions of polycarboxylic acids, such as citric, malic, fumaric, malonic, and succinic acids, exhibited a high virucidal activity against enveloped viruses on their own, in the absence of other biocidal agents, 50 and have found practical applications as an additional ingredient in disinfectant solutions. 51 , 52 …”

Section: Resultsmentioning

confidence: 99%

Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?

Mileto

Mancon

Staurenghi

et al. 2021

ACS Chem. Health Saf.

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A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log 10 diminution in 15 min. Conversely, H 2 O 2 solutions with no additives displayed a scarce virucidal activity (1.1 log 10 diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H 2 O 2 -based disinfectant active against the novel coronavirus.

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“…Ayhan and Bilici informed that an acidic environment disrupts the cell wall structure causing a loss of ATP in the cell [65]. In addition, some authors reported that citric acid at a concentration of 1% effectively inactivated avian influenza virus (AIV) on hard and nonporous surfaces [66]. However, the incorporation of the Cu does not improve the capability of these formulations as antiviral with respect to CH.CA formulations at the conditions studied.…”

Section: Antiviral Assays Of the Chitosan-based Materialsmentioning

confidence: 99%

Development and Characterization of Antimicrobial Textiles from Chitosan-Based Compounds: Possible Biomaterials Against SARS-CoV-2 Viruses

Favatela

Otarola

Ayala-Peña

et al. 2022

J Inorg Organomet Polym

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Novel antiviral cotton fabrics impregnated with different formulations based on Chitosan (CH), citric acid (CA), and Copper (Cu) were developed. CA was selected as a CH crosslinker agent and Cu salts as enhancers of the polymer antimicrobial activity. The characterization of the polymeric-inorganic formulations was assessed by using atomic absorption spectroscopy, X-ray diffraction, Fourier transform infrared and UV-Vis spectroscopy, as well as thermogravimetric analysis. The achieved data revealed that CuO nanoparticles were formed by means of chitosan and citric acid in the reaction media. The antiviral activity of CH-based formulations against bovine alphaherpesvirus and bovine betacoronavirus was analyzed. Cotton fabrics were impregnated with the selected formulations and the antiviral properties of such textiles were examined before and after 5 to 10 washing cycles. Herpes simplex virus type 1 was selected to analyze the antiviral activities of the functionalized cotton fabrics. The resulting impregnated textiles exhibited integrated properties of good adhesion without substantially modifying their appearance and antiviral efficacy (~ 100%), which enabling to serve as a scalable biocidal layer in protective equipment's by providing contact killing against pathogens. Thus, the results revealed a viable contribution to the design of functional-active materials based on a natural polymer such as chitosan. This proposal may be considered as a potential tool to inhibit the propagation and dissemination of enveloped viruses, including SARS-CoV-2.

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Virucidal efficacy of a disinfectant solution composed of citric acid, malic acid and phosphoric acid against avian influenza virus

Cited by 10 publications

References 15 publications

Controlled Release of Molecular Intercalants from Two-Dimensional Nanosheet Films

Controlled Release of Molecular Intercalants from Two-Dimensional Nanosheet Films

Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?

Development and Characterization of Antimicrobial Textiles from Chitosan-Based Compounds: Possible Biomaterials Against SARS-CoV-2 Viruses

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