Viral inhibitors to control the Papaya ringspot virus on Carica papaya

Abstract

is a very challenging virus to combat and prevents achieving a high productive potential in Carica papaya due to the lack of resistant genes in commercial papaya cultivars such as red Maradol, which originated in Cuba and extends to all America and the Caribbean. In this study, the effectiveness of a new viral inhibitor (Inhibitovir), applied as a preventive and curative treatment to control PRSV was evaluated under field conditions. The results showed the possibility of using this viral inhibitor against PRSV because its effectiveness was comparable to that of the commercial antiviral (Q-2000VI). The use of Inhibitovir can prevent the damages caused by PRSV with satisfactory protection until harvest, allowing yield increases of 1.5 to 3 times. The preventive effect of Inhibitovir applications can attenuate and reduce disease symptoms, even in those plants that were infected prior to treatment. The field application of a new antiviral formulation offers a new alternative for efficient PRSV control, which can be included in integrated pest management.

Viruses Infecting Trees and Herbs That Produce Edible Fleshy Fruits with a Prominent Value in the Global Market: An Evolutionary Perspective

“…The chemicals used in crop protection against viral infections are called viricides. Some viricides are currently on the market for PRSV treatment or prevention, such as Virus Stop (Fagro S.A., Mexico), Q 2000 VI (Quimcasa, Mexico), Antivirus (Fertinosa, Mexico) and Ekologik (Bioaga Cellular Biology Lab, USA) [457]. Additionally, a new viricide called Inhibitovir can prevent and reduce disease caused by PRSV, comparable to Q-2000VI, with satisfactory protection until harvest [457].…”

“…Some viricides are currently on the market for PRSV treatment or prevention, such as Virus Stop (Fagro S.A., Mexico), Q 2000 VI (Quimcasa, Mexico), Antivirus (Fertinosa, Mexico) and Ekologik (Bioaga Cellular Biology Lab, USA) [457]. Additionally, a new viricide called Inhibitovir can prevent and reduce disease caused by PRSV, comparable to Q-2000VI, with satisfactory protection until harvest [457]. On the other hand, the common broad-spectrum disinfectants Lactoferrin, Virocid, Clorox, and Virkon showed activities against the tobamoviruses TBRFV and CGMMV, with an efficacy of 90-100% [458].…”

Efecto de inhibidores en el control del Papaya ringspot virus y productividad en papaya (Carica papaya)

“…densidades de 2,800 plantas ha -1 , eliminación de plantas con síntomas iniciales del PRSV, aplicación de citrolina al 1.5 %, y establecimiento de barreras de maíz y jamaica, entre otras (GIP, 1994;García et al, 1995). También se han utilizado productos "antivirales" o "inhibidores virales" en plantas de papaya que disminuyen la incidencia y severidad (Hernández et al, 2017). Es por ello que en esta investigación se evaluaron los efectos de Inhibitovir ® y Virus Stop ® sobre la incidencia, intensidad de daño y eficacia de control del PRSV, así como en el crecimiento y productividad de plantas de papaya.…”

“…La intensidad de la enfermedad varió de 15.3 a 27.7% pero sin diferencias significativas entre tratamientos (Cuadro 1). Estos resultados fueron diferentes a los reportados por Hernández et al (2017) al aplicar Inhibitovir ® y Q-2000VI ® , observaron una reducción del porcentaje de intensidad del PRSV hasta los 160 días con diferencias significativas.…”