VIP in the rat parotid gland in response to irradiation

Analysis of VIP and CGRP Plasma Levels After Radiotherapy for Treatment of Metastasis from Prostatic Carcinoma

“…The reason for analyzing VIP is that this peptide is one of the peptides the expression of which has been found to be markedly increased in tissues in response to radiotherapy. 4,5 Furthermore, there is some degree of correlation between tissue and plasma VIP concentrations in another situation, namely ulcerative colitis, both types of concentrations significantly decreasing in patients expressing mild or minimal disease. 7 The plasma levels of CGRP have been found to be changed under various conditions in man.…”

“…In the present study, the levels of VIP‐ and CGRP‐like peptides in plasma from patients treated with radiotherapy were analyzed. The reason for analyzing VIP is that this peptide is one of the peptides the expression of which has been found to be markedly increased in tissues in response to radiotherapy 4,5. Furthermore, there is some degree of correlation between tissue and plasma VIP concentrations in another situation, namely ulcerative colitis, both types of concentrations significantly decreasing in patients expressing mild or minimal disease 7.…”

“…These includes the situation in the main salivary glands 1,2 and laryngeal glands 3 of the rat on examination 10 days after radiotherapy, and in the rat and human gut on examination 5-10 days after irradiation. 4,5 Also, in the studies by Otterson and colleagues, 6 changes in VIP and SP concentrations were noted in various layers of the dog intestine after fractionated irradiation.…”

“…In a large number of studies we have observed that irradiation with high energy photons affects the immunohistochemical expression and content of various neuropeptides in several organs. These includes the situation in the main salivary glands1,2 and laryngeal glands3 of the rat on examination 10 days after radiotherapy, and in the rat and human gut on examination 5–10 days after irradiation 4,5. Also, in the studies by Otterson and colleagues,6 changes in VIP and SP concentrations were noted in various layers of the dog intestine after fractionated irradiation.…”

“Denervation” of autonomous nervous system in idiopathic pulmonary arterial hypertension by low-dose radiation: a case report with an unexpected outcome

“…It has to be mentioned that central neuronal structures are generally considered to be more radiosensitive than peripheral structures. Höckerfelt et al9 reported a significant more than three-fold increase in vasoactive intestinal peptide (VIP) content in the rat parotid gland at 10 days following cessation of a 5-day treatment with a total radiation dose of 30–40 Gy. In a study by Otterson et al,10 a significant twofold increase in intestine VIP content was reported in dogs after a total dose of 1,500 Gy in 250 Gy fractions, although accompanied with some regional variations.…”